قرص xanax 0.5

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قرص xanax 0.5
قرص xanax 0.5

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قرص xanax 0.5

 

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Kaiser Permanente health plans around the country: Kaiser Foundation Health Plan, Inc., in Northern and Southern California and Hawaii • Kaiser Foundation Health Plan of Colorado • Kaiser Foundation Health Plan of Georgia, Inc., Nine Piedmont Center, 3495 Piedmont Road NE, Atlanta, GA 30305, 404-364-7000 • Kaiser Foundation Health Plan of the Mid-Atlantic States, Inc., in Maryland, Virginia, and Washington, D.C., 2101 E. Jefferson St., Rockville, MD 20852 • Kaiser Foundation Health Plan of the Northwest, 500 NE Multnomah St., Suite 100, Portland, OR 97232 • Kaiser Foundation Health Plan of Washington or Kaiser Foundation Health Plan of Washington Options, Inc., 601 Union St., Suite 3100, Seattle, WA 98101

© 2019 Kaiser Foundation Health Plan, Inc.

8-Chlor-1-methyl-6-phenyl-4H-[1,2,4]-triazolo[4,3-a][1,4]benzodiazepin

N05BA12

Feststoff[1]

228–228,5 °C[1]

2,4[3]

قرص xanax 0.5

löslich in Ethanol, unlöslich in Wasser[1]

Achtung

1220 mg·kg−1 (LD50, Ratte, oral)[4]


Alprazolam ist ein Arzneistoff aus der Gruppe der Benzodiazepine mit mittlerer Wirkungsdauer, der zur kurzzeitigen Behandlung von Angst- und Panikstörungen eingesetzt wird.

Alprazolam wirkt beruhigend und angstlösend. Es wird zur kurzzeitigen symptomatischen Behandlung von Angstzuständen und von Panikstörungen sowie zur Behandlung der Übelkeit bei einer Chemotherapie eingesetzt.[5]

Alprazolam wird im Rahmen der Therapie von Depressionen[6] bzw. als Behandlung von Begleit-Depressionen bei Angstzuständen[7] verwendet. Es zeigt bei akuten oder Kurzzeitbehandlungen antidepressive Eigenschaften.[8]

Die Anwendung als Schlafmittel ist zwar häufig, allerdings hat Alprazolam dafür keine Indikation (Off-Label-Use).

Die Dosierung und die Dauer der Anwendung werden an die individuelle Reaktionslage, das Indikationsgebiet und die Schwere der Erkrankung angepasst. Hierbei gilt der Grundsatz, die Dosis so gering und die Behandlungsdauer so kurz wie möglich zu halten, um die Gefahr einer psychischen und physischen Abhängigkeit zu minimieren. Es wird empfohlen, die Gesamtdauer – einschließlich der Ausschleichphase – acht bis zwölf Wochen nicht übersteigen zu lassen.[6][9] Der Patient sollte außerdem in regelmäßigen Abständen untersucht werden, um die Notwendigkeit einer fortgesetzten Behandlung zu überprüfen. Um Entzugserscheinungen beim Absetzen von Alprazolam zu vermeiden, wird die Dosis langsam reduziert.

Die Anwendung von Alprazolam bei folgenden Erkrankungen ist problematisch:[6][7][9]

Alkohol kann die Wirkung von Alprazolam in nicht vorhersehbarer Weise verändern.

Bei gleichzeitiger Anwendung von Alprazolam mit folgenden Arzneimitteln kann es zu gegenseitiger Verstärkung der zentraldämpfenden Wirkung kommen:

Arzneimittel, welche über das Cytochrom P450 3A4 abgebaut werden, können die Konzentration und Wirksamkeit von Alprazolam erhöhen.

Die gleichzeitige Verabreichung von Ketoconazol, Itraconazol oder anderen Antimykotika vom Azol-Typ ist kontraindiziert.

Wechselwirkungen zwischen HIV-Protease-Inhibitoren (z. B. Ritonavir) und Alprazolam sind komplex und zeitabhängig. Niedrige Dosen von Ritonavir führen zu einer deutlichen Einschränkung der Alprazolam-Clearance, was dessen Halbwertszeit verlängert und die klinische Wirksamkeit erhöht. Allerdings hebt die CYP3A-Induktion diese Hemmung bei längerer Anwendungsdauer von Ritonavir wieder auf. Die Interaktion erfordert entweder eine Dosisreduktion oder ein Absetzen von Alprazolam.

Probleme können bei der gleichzeitigen Einnahme von folgenden Medikamenten auftreten:

Alprazolam darf nicht während der Schwangerschaft verwendet werden. Frauen im gebärfähigen Alter wird geraten, die Medikation abzusetzen, wenn sie schwanger sind oder die Absicht haben, schwanger zu werden. Wenn eine Verabreichung des Präparates in der Spätphase der Schwangerschaft oder hochdosiert während der Geburtswehen aus dringenden medizinischen Gründen unumgänglich ist, muss mit nachteiligen Wirkungen auf das Neugeborene gerechnet werden. Diese können Hypotonie, Ateminsuffizienz, Hypothermie, herabgesetzte Muskelspannung und Trinkschwäche (floppy infant syndrome) umfassen.[6][9]

Da Alprazolam in die Muttermilch übergeht und dort kumuliert, soll das Präparat während des Stillens nicht verabreicht werden. Neugeborene metabolisieren Benzodiazepine wesentlich langsamer als Erwachsene.[6][9]

Die Wirksamkeit und Unbedenklichkeit von Alprazolam bei Kindern und Jugendlichen unter 18 Jahren wurde nicht untersucht.[7]

Die häufigsten Nebenwirkungen sind Somnolenz und Benommenheit/Schwindel. Weiterhin können folgende Nebenwirkungen auftreten, insbesondere zu Beginn der Therapie: verringerte Aufmerksamkeit, Müdigkeit, gedämpfte Emotionen, Verwirrtheit, Muskelschwäche, Ataxie, Bewegungs- und Gangunsicherheit (Sturzgefahr besonders bei älteren Patienten), Tremor, Kopfschmerzen, Sehstörungen, Störungen des vegetativen Nervensystems (Gewichtsänderung, gastrointestinale Störungen, Blasenfunktionsstörungen). In der Regel verringern sich diese Symptome bei wiederholter Anwendung.

Weiterhin wurden Anorexie, Hyperprolaktinämie, Menstruationsstörungen und Störungen der Leberfunktion (z. B. Gelbsucht) beobachtet. Über Änderungen der Libido und Hautreaktionen wurde gelegentlich berichtet. Selten kann es zu einer Atemdepression kommen, insbesondere während der Nacht.

Es wird Patienten, die Alprazolam einnehmen, nicht empfohlen, Auto zu fahren, komplexe Maschinen zu bedienen oder andere potenziell gefährliche Tätigkeiten auszuführen, solange nicht bekannt ist, ob die Fähigkeit zur Ausübung solcher Tätigkeiten beeinträchtigt wird.[7]

Mit der Dauer der Einnahme von Alprazolam über mehrere Wochen kann es durch eine Toleranzentwicklung zum Nachlassen der Wirkung kommen.

Wie alle Benzodiazepine kann auch Alprazolam schon nach kurzer Einnahmedauer zu einer psychischen und körperlichen Abhängigkeit führen. Das Risiko für eine Sucht steigt mit der Höhe der Dosierung und der Länge der Medikamenteneinnahme. Patienten mit bekannten Tablettenabhängigkeit, Drogen- oder Alkoholsucht in der Vorgeschichte haben ein erhöhtes Risiko der Suchtentwicklung.

Wurde eine physische Abhängigkeit von Alprazolam entwickelt, löst ein abruptes Absetzen des Arzneimittels Entzugserscheinungen, wie z. B. Kopf- und Muskelschmerzen, Angstzustände, Spannung, Unruhe, Verstörtheit und Reizbarkeit aus. In schweren Fällen können Realitätsverlust, Persönlichkeitsverlust, Hyperacusis, Taubheitsgefühl und Kribbeln in den Extremitäten, Überempfindlichkeitsreaktionen auf Licht, Lärm und körperlichen Kontakt, Halluzinationen oder epileptische Anfälle auftreten. Die häufigen Entzugserscheinungen nach einer Alprazolam-Therapie sind in der Literatur gut dokumentiert.[10]

Nach dem Absetzen der Medikation kann es auch zum Auftreten eines sogenannten Rebound-Phänomenen kommen. Hier treten die Symptome, die zu einer Behandlung mit Benzodiazepinen führten, in verstärkter Form wieder auf. Als Begleitreaktionen sind Stimmungswechsel, Angstzustände und Unruhe möglich. Da nach einem abrupten Absetzen der Medikation die Entzugserscheinungen häufiger auftreten, ist eine schrittweise Reduktion der Dosierung empfohlen.[6][7][9]

Eine Überdosierung von Alprazolam führt zu einer allgemeinen zentralnervösen Dämpfung, die von Benommenheit bis hin zum Koma reichen kann. Durch die alleinige Einnahme von Alprazolam besteht im Allgemeinen keine Lebensgefahr, es sei denn in Kombination mit anderen zentral wirksamen Substanzen oder Alkohol; hierdurch kann es zum Atemstillstand kommen und eine Unterstützung der Vitalfunktionen nötig werden.

Zur Entgiftung kann bei bewusstseinsklaren Patienten Erbrechen herbeigeführt werden bzw. nach Intubation eine Magenspülung und Behandlung mit Aktivkohle durchgeführt werden. Die Behandlung mit Flumazenil als Antidot kann in Erwägung gezogen werden. Eine forcierte Diurese oder Dialysebehandlung ist dagegen wirkungslos.[7]

Alprazolam bindet im Gehirn an GABA-Rezeptoren und erhöht auf diese Weise die inhibitorischen Effekte des Neurotransmitters GABA.[7]

Neben unmetabolisiertem Alprazolam (ca. 20 %) werden als Hauptmetaboliten α-Hydroxyalprazolam (ca. 17 %) sowie 4-Hydroxyalprazolam ausgeschieden. Darüber hinaus sind eine Vielzahl weiterer Metabolite identifiziert worden. Die pharmakologische Aktivität von α-Hydroxyalprazolam beträgt ca. 50 %, verglichen mit Alprazolam. 4-Hydroxyalprazolam zeigt keine pharmakologische Aktivität. Die Halbwertszeit der beiden Hauptmetabolite liegt im gleichen Bereich wie die von Alprazolam. Die Metaboliten tragen aufgrund niedriger Konzentration wahrscheinlich kaum zum therapeutischen Effekt bei.

Alprazolam wird nach oraler Gabe rasch und gut resorbiert. Maximale Plasmaspiegel werden nach einmaliger oraler Gabe nach ein bis zwei Stunden erreicht. Die Bioverfügbarkeit liegt bei 80 %. Die Plasmaproteinbindung beträgt 70 bis 80 %. Das Verteilungsvolumen beträgt durchschnittlich 1,0 bis 1,2 l/kg und ist bei adipösen Patienten signifikant größer. Die Eliminationshalbwertszeit nach einmaliger Gabe liegt zwischen 12 und 15 Stunden. Bei älteren männlichen Patienten kann die Eliminationshalbwertzeit verlängert sein.

Die verzögerte Wirkstofffreisetzung der Retard-Tablette beeinflusst die Distribution, den Metabolismus und die Elimination von Alprazolam nicht. Die Serumspitzenkonzentrationen werden fünf bis elf Stunden nach der Gabe einer Retard-Tablette erreicht.[6][9]

Alprazolam tritt in verschiedenen Kristallformen auf. Mittels thermoanalytischer Untersuchungen und Röntgenbeugungsmessungen konnten zwei polymorphe Formen, ein Dihydrat und zwei nichtstöchiometrische Solvate mit Ethanol und Acetonitril charakterisiert werden.[2] Für das kommerzielle Polymorph I und das Dihydrat wurden die Kristallstrukturen bestimmt. Beide kristallieren in einem triklinen Gitter, das Polymorph I mit einer Raumgruppe P1 bzw. das Dihydrat mit der Raumgruppe P1.[2] Die Desolvatation des Dihydrates und des Ethanolsolvates ergeben das Polymorph I. Aus dem Acetonitrilsolvat resultiert das Polymorph II, welches mit 233 °C einen etwas höheren Schmelzpunkt besitzt.[2]

Alprazolam wurde durch die Firma Upjohn (später von Pfizer übernommen) entwickelt und 1984 unter dem Namen Tafil auf den deutschen Markt gebracht.[11] Sein Patentschutz endete im Jahre 1993.

Tafil (D), Xanax, Xanax retard (CH, USA), Xanor (A), zahlreiche Generika (D, A)[6][7][9]

قرص زاناکس یا آلپرازولام از خانواده بنزودیازپین مانند دیازپام، کلونازپام و لورازپام است و برای کنترل بیماری هایی از قبیل اضطراب، بی قراری، حملات هراس، بی خوابی و برخی دیگر از اختلالات روانی تجویز می شود. این قرص را به نام نیراوام نیز می شناسند.

قرص زاناکس در دوزهای 0.25 میلی گرم، 0.5، 1 و 2 میلی گرم تولید و عرضه می گردد. دوز یکسان، اثر آن تا 10 برابر بیشتر از قرص والیوم یا دیازپام می باشد.این قرص سیزدهمین داروی پر فروش آمریکا است.

قرص زاناکس فعالیت سیستم اعصاب مرکزی را سرکوب می کند به این معنی که فعالیت، تحریک پذیری و واکنش مغز را کاهش می دهد و اجازه می دهد مغز و سیستم اعصاب مرکزی زمان بیشتری برای استراحت داشته باشند، این مسئله سبب تعادل بین سیستم اعصاب سمپاتیک و پاراسمپاتیک می شود، به عبارتی می توان گفت آلپرازولام یا زاناکس اثر آرامبخش و کسل کنندگی دارد. قرص آلپرازولام از سرعت حرکت ناقل های شیمیایی در مغز که ممکن است نامتعادل باشند می کاهد و نتیجه این کاهش از فعالیت های غیر طبیعی مغز، تنش های عصبی و اضطراب کم می کند. زاناکس این کار را با افزایش فعالیت گابا انجام می دهد، گابا آمینو بوتیریک اسید یک ماده شیمیایی طبیعی از گروه اسیدهای آمینه است که در مغز تولید و به عنوان یک انتقال دهنده عصبی، موجب افزایش حس آرامش و استراحت پذیری می شود.

هنگامی که شخص بیمار اضطراب، هراس و یا تشنج را تجربه می کند فعالیت مغز او به شدت بالا بوده و در حالی قرار دارد که به آن آماده باش می گویند، در این حالت فرد قادر به کنترل فعالیت های ذهنی خود نیست و به دنبال آن علایمی مانند افزایش ضربان قلب و سرعت تنفس، تعریق  را تجربه می کند، مصرف داروی زاناکس در این بیماران منجر به کاهش فعالیت مغز شده و در نتیجه ذهن آرام می شود و جسم کاهش اضطراب، ضربان قلب و آرامش پیدا می کند.قرص xanax 0.5

در بیشتر افراد علت بی خوابی،  عدم کنترل افکار و فعالیت بیش از حد مغز است، در این افراد هنگام شب بدن خسته اما ذهن فعال بوده و به طور غیر ارادی به موضوعات مختلف معطوف می شود و فرد توان کافی برای مهار این افکار را ندارد.

مصرف قرص زاناکس در این اشخاص سبب کاهش فعالیت مغز شده و به فکر پراکنی های بیهوده پایان می دهد و زمینه را برای خواب و استراحت کافی فراهم می کند و با این مکانیزم این دارو به عنوان یک قرص خواب آور نیز شناخته می شود.

توجه کنید که اگر پزشک شما این دارو را برای درمان بی خوابی تجویز کرده است آن را دیر وقت در شب مصرف نکنید زیرا در روز بعد احساس خواب آلودگی و گیجی خواهید داشت. برنامه مصرف را طوری تنظیم کنید که آغاز فعالیت روزانه شما حداقل 10 ساعت بعد از مصرف این دارو باشد، به عنوان مثال اگر صبح ساعت 8 از خواب بیدار می شوید قرص آلپرازولام یا زاناکس را ساعت 9 الی 10 شب مصرف کنید تا هم از خواب کافی برخوردار شوید و هم هنگام بیدار شدن تقریبا با پایان اثر دارو همزمان باشد. همچنین مواد فعال در این دارو از طریق ادرار دفع می شوند و شما برای سرعت بخشیدن به این عمل می توانید در صبح قبل از صرف ناشتایی دو لیوان آب بخورید تا زودتر تاثیر آن بر طرف گردد.

دقت کنید که سرعت تاثیر این دارو در بدن هر فرد متفاوت بوده و بسته به سن، شدت بیماری و سوخت و ساز بدن متغیر است و در عده ای بعد از جذب کمتر از پنج دقیقه تاثیر می گذارد.

به طور متوسط نیمه عمر این دارو یازده ساعت است اما در برخی اشخاص که شدت بیماری بالا بوده نیاز به مصرف چند دوز در روز می باشد.

اگر قرص زاناکس را با معده خالی و قبل از صرف غذا مصرف نمایید به مدت پنج تا نیم ساعت بعد از جذب اثر می کند. همچنین قرار دادن قرص در زیر زبان نیز جذب و اثر آن را سرعت می بخشد.

قرص زاناکس برای تمام اشخاص مناسب نیست و مصرف سر خود آن اعتیاد آور است و استفاده از زاناکس در افرادی که سابقه اعتیاد به مواد مخدر و الکل دارند به هیچ عنوان توصیه نمی گردد.

این دارو به شکل خوراکی مصرف می شود و تجویز  دوز مصرف بستگی به شدت بیماری، سن و میزان واکنش بدن به این دارو دارد، معمولا پزشک درمان را با دوز کم آغاز می کند و در صورت نیاز به آرامی و طی چند هفته بر میزان دوز مصرفی می افزاید تا مشخص شود چه دوزی برای بیمار مناسب و موثرتر می باشد. این دارو را دقیقا مطابق دستور پزشک مصرف کنید و بدون مشورت با پزشک اقدام به کاهش، افزایش دوز، قطع مصرف و مصرف مجدد آن به هیچ وجه نکنید.

قرص زاناکس معمولا برای کنترل بیماری ها در زمان کوتاه تجویز می شود نه برای مصارف طولانی مدت، پس اگر نیاز به ادامه مصرف دارو بود حتما با پزشک خود مشورت نمایید. امکان دارد به مرور زمان از میزان تاثیر این دارو کاسته شود، اگر بعد از مدتی احساس کردید اثر این دارو کم شده است حتما به پزشک خود اطلاع دهید.

بیشترین عارضه جانبی قرص زاناکس اعتیاد آور بودن آن می باشد که به همین دلیل مصرف طولانی مدت آن به هیچ وجه نباید اتفاق بیفتد و از دیگر عوارض جانبی زاناکس یا آلپرازولام می توان به موارد زیر اشاره کرد:

در صورتی که هر یک از این موارد که در ادامه اشاره می شود را در خود احساس کردید، مصرف دارو را قطع کنید:

اگر هر یک از نشانه های زیر را در خود مشاهده نمودید، فورا با مرکز فوریت های پزشکی تماس بگیرید:

توجه داشته باشید اگر از این قرص درست و به جا استفاده شود یک آرامبخش موثر و مفید می باشد و این عوارض تنها در تعداد معدودی به علت سرپیچی از دستور پزشک اتفاق میفتد.

داروی زاناکس با بسیاری از داروها در صورت مصرف همزمان تداخل دارد و قبل از استفاده از این قرص اگر از داروی دیگری استفاده می کنید باید پزشک خود را مطلع سازید. این قرص با داروهای نام برده شده در زیر تداخل دارویی دارد:

قرص زاناکس نباید همراه با دارویی هایی که موجب خواب آلودگی می شوند همانند آنتی هیستامین ها، دیفن هیدرامین، دیازپام، زولپیدم، اکثر داروهای شل کننده عضلات، ضد دردها مانند کدئین، کلرپرومازین، ریسپریدون، امی تریپتیلین و ترازودون مصرف شود.

این دارو را در دمای 20 تا 25 درجه سانتی گراد و به دور از دسترس اطفال نگهداری کنید.

مصرف این قرص در بارداری، شیردهی و افراد زیر 18 سال ممنوع می باشد.

قبل از شروع به مصرف قرص زاناکس نکات ذکر شده در این قسمت را جدی بگیرید:

نکات و توصیه های درج شده در اطلاعات دارویی قرص زاناکس را جدی بگیرید و بدانید که تاثیر و نیمع عمر این قرص در نژاد آسیایی بیشتر از سایرین می باشد.

منبع : آرگا



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Generic name: ALPRAZOLAM 0.25mgDosage form: tablet

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Medically reviewed by Drugs.com. Last updated on Sep 13, 2018.

Dosage should be individualized for maximum beneficial effect. While the usual daily dosages given below will meet the needs of most patients, there will be some who require doses greater than 4 mg/day. In such cases, dosage should be increased cautiously to avoid adverse effects.

Treatment for patients with anxiety should be initiated with a dose of 0.25 to 0.5 mg given three times daily. The dose may be increased to achieve a maximum therapeutic effect, at intervals of 3 to 4 days, to a maximum daily dose of 4 mg, given in divided doses. The lowest possible effective dose should be employed and the need for continued treatment reassessed frequently. The risk of dependence may increase with dose and duration of treatment.قرص xanax 0.5

In all patients, dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. Although there are no systematically collected data to support a specific discontinuation schedule, it is suggested that the daily dosage be decreased by no more than 0.5 mg every 3 days. Some patients may require an even slower dosage reduction.

The successful treatment of many panic disorder patients has required the use of XANAX at doses greater than 4 mg daily. In controlled trials conducted to establish the efficacy of XANAX in panic disorder, doses in the range of 1 to 10 mg daily were used. The mean dosage employed was approximately 5 to 6 mg daily. Among the approximately 1700 patients participating in the panic disorder development program, about 300 received XANAX in dosages of greater than 7 mg/day, including approximately 100 patients who received maximum dosages of greater than 9 mg/day. Occasional patients required as much as 10 mg a day to achieve a successful response.

Treatment may be initiated with a dose of 0.5 mg three times daily. Depending on the response, the dose may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. Slower titration to the dose levels greater than 4 mg/day may be advisable to allow full expression of the pharmacodynamic effect of XANAX. To lessen the possibility of interdose symptoms, the times of administration should be distributed as evenly as possible throughout the waking hours, that is, on a three or four times per day schedule.

Generally, therapy should be initiated at a low dose to minimize the risk of adverse responses in patients especially sensitive to the drug. Dose should be advanced until an acceptable therapeutic response (ie, a substantial reduction in or total elimination of panic attacks) is achieved, intolerance occurs, or the maximum recommended dose is attained.

For patients receiving doses greater than 4 mg/day, periodic reassessment and consideration of dosage reduction is advised. In a controlled postmarketing dose-response study, patients treated with doses of XANAX greater than 4 mg/day for 3 months were able to taper to 50% of their total maintenance dose without apparent loss of clinical benefit. Because of the danger of withdrawal, abrupt discontinuation of treatment should be avoided. (See WARNINGS, PRECAUTIONS, DRUG ABUSE AND DEPENDENCE.)

The necessary duration of treatment for panic disorder patients responding to XANAX is unknown. After a period of extended freedom from attacks, a carefully supervised tapered discontinuation may be attempted, but there is evidence that this may often be difficult to accomplish without recurrence of symptoms and/or the manifestation of withdrawal phenomena.

Because of the danger of withdrawal, abrupt discontinuation of treatment should be avoided (see WARNINGS, PRECAUTIONS, DRUG ABUSE AND DEPENDENCE).

In all patients, dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. Although there are no systematically collected data to support a specific discontinuation schedule, it is suggested that the daily dosage be decreased by no more than 0.5 mg every three days. Some patients may require an even slower dosage reduction.

In any case, reduction of dose must be undertaken under close supervision and must be gradual. If significant withdrawal symptoms develop, the previous dosing schedule should be reinstituted and, only after stabilization, should a less rapid schedule of discontinuation be attempted. In a controlled postmarketing discontinuation study of panic disorder patients which compared this recommended taper schedule with a slower taper schedule, no difference was observed between the groups in the proportion of patients who tapered to zero dose; however, the slower schedule was associated with a reduction in symptoms associated with a withdrawal syndrome. It is suggested that the dose be reduced by no more than 0.5 mg every 3 days, with the understanding that some patients may benefit from an even more gradual discontinuation. Some patients may prove resistant to all discontinuation regimens.

In elderly patients, in patients with advanced liver disease or in patients with debilitating disease, the usual starting dose is 0.25 mg, given two or three times daily. This may be gradually increased if needed and tolerated. The elderly may be especially sensitive to the effects of benzodiazepines. If side effects occur at the recommended starting dose, the dose may be lowered.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Other brands: Alprazolam Intensol, Niravam

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In this article, we will explain why Xanax is used, potential side effects, and relevant warnings.

Xanax (alprazolam) is an anti-anxiety medication in the benzodiazepine family, the same family that includes diazepam (Valium), clonazepam (Klonopin), lorazepam (Ativan), flurazepam (Dalmane), and others.

Xanax works by decreasing abnormal excitement in the brain and was approved by the FDA in October 1981.

Benzodiazepines act on the brain and central nervous system to produce a calming effect.

Xanax slows down the movement of brain chemicals that may have become unbalanced, resulting in a reduction in nervous tension and anxiety. Xanax works by boosting the effects of a natural chemical made in the brain called gamma-aminobutyric acid (GABA).

For all users of Xanax:

To ensure safe and effective use of benzodiazepines, all patients prescribed with Xanax will be provided with the following guidance:

Inform your doctor if you have asthma or other breathing problems, glaucoma, kidney, or liver diseases, history of alcoholism or depression, suicidal thoughts, or an addiction to drugs or alcohol.

You should not take Xanax if you:

In certain individuals, the body handles Xanax differently, these include:

Do not use Xanax if you are allergic to alprazolam or other benzodiazepines such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Do not drink alcohol while taking Xanax. Xanax can increase the effects of alcohol.

Do not use Xanax if you are pregnant. Benzodiazepines can potentially cause harm to the fetus. Xanax increases the risk of congenital abnormalities when given to a pregnant woman during the first trimester.

Use of Xanax during the first trimester of pregnancy should usually be avoided.

Patients should be advised that if they become pregnant during therapy or intend to become pregnant, they should tell their doctor.

A child born of a mother who is taking benzodiazepines may be at risk of withdrawal symptoms from the drug. Also, respiratory problems have been reported in children born to mothers who have been taking benzodiazepines.

It is thought that Xanax is excreted in human milk. As a general rule, mothers who must use Xanax should not breast-feed.

Xanax has not been studied in children.

Gender does not effect the body’s response to Xanax.

Older adults may be more sensitive to the effects of benzodiazepines. The sedative effects of Xanax may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Xanax.

Xanax may affect Asian populations more than white populations.

Xanax concentrations may be reduced up to 50 percent in smokers, compared with nonsmokers.

As with other psychotropic medications, there are precautions when giving the drug to severely depressed patients or those who may have suicidal thoughts.

Episodes of hypomania and mania have been reported in association with the use of Xanax in patients with depression.

Xanax is often abused for the fast-acting, relaxed “high” it can give to people who take it, including people without a prescription.قرص xanax 0.5

According to the Treatment Episode Data Set, the number of individuals seeking treatment for benzodiazepine abuse almost tripled from 1998-2008. Long-term abuse and addiction to Xanax are associated with depression, psychotic experiences, and aggressive or impulsive behavior.

According to the Substance Abuse and Mental Health Services Administration, in 2011, there were over 1.2 million emergency department (ER) visits overall related to the nonmedical use of prescription drugs – Xanax was involved in 10 percent of those visits.

The number of emergency department visits involving the non-medical use of the sedative Xanax doubled from 57,419 to 124,902 during the years 2005 to 2010 and then remained stable at 123,744 in 2011.

The most common drug combinations encountered in ER patients are Xanax and alcohol, and Xanax combined with prescription opiates like hydrocodone and oxycodone.

Xanax is used to manage anxiety disorder or the short-term relief of symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment.

Generalized anxiety disorder is characterized by unrealistic or excessive anxiety and worry about two or more life circumstances, for a period of 6 months or longer, during which the person has been bothered more days than not by these concerns.

At least six of the following symptoms are often present in these patients:

Xanax is also indicated for the treatment of panic disorder, with or without agoraphobia, and may reduce the number of panic attacks experienced.

Panic disorder is characterized by regular panic attacks. Panic attacks are relatively short periods of intense fear or discomfort where four or more of the following symptoms develop all of a sudden and reach a peak within 10 minutes:

Side effects are often observed at the beginning of therapy and usually disappear upon continued use of medication. Possible side effects of Xanax include:

The above is not a complete list of side effects and others may occur. Call a doctor for medical advice about side effects. Side effects can be reported to the FDA at 1-800-FDA-1088.

Seek emergency medical help if you have any of these signs of an allergic reaction to Xanax: hives, difficulty breathing, and swelling of the face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

Xanax comes as a tablet, an extended-release tablet, an orally disintegrating tablet (tablet that dissolves quickly in the mouth), and a concentrated solution (liquid) to take by mouth.

Xanax should be taken by mouth as directed by a doctor. Dosage is based on the following factors:

The dosage of Xanax may be increased gradually until the drug works effectively for the patient. The instructions of a doctor should be closely followed to reduce the risk of side effects.

If this medication has regularly been used for a long time or in high doses, withdrawal symptoms (such as seizures) can occur if usage is suddenly stopped. To prevent these reactions, the doctor may reduce the dosage of Xanax gradually.

Xanax is available in doses of:

Do not crush, chew, or break a Xanax extended-release tablet. Swallow the tablet whole. It is specially made to release medicine slowly in the body. Breaking the tablet would cause too much of the drug to be released at one time.

Do not share your medicine with other people. It may not be suitable for them and may harm them.

If you miss a dose of Xanax, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Symptoms of a Xanax overdose include tiredness, confusion, impaired coordination, diminished reflexes, and coma. Death has been reported in association with overdoses of Xanax by itself, as it has with other benzodiazepines.

If an overdose of Xanax occurs, call your doctor or 911. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Xanax should be stored at controlled room temperature 20-25°C.

The following drugs may increase the effects of Xanax:

Benzodiazepines, including Xanax, produce extra depressant effects on the central nervous system (CNS) when taken with:

Other possible negative drug interactions include:

Studies of benzodiazepines other than Xanax suggest a possible drug interaction with the following drugs:

This list is not complete, and other drugs may interact with Xanax. Tell your doctor about all medications you use. This includes prescription, OTC, vitamin, and herbal products.

Do not start a new medication without telling your doctor.

It is important to taper off Xanax gradually; otherwise, there is a risk of benzodiazepine withdrawal syndrome.

To discontinue treatment of Xanax, the dosage should be reduced and tapered slowly. It is suggested that the daily dosage of Xanax be decreased by no more than 0.5 milligrams every 3 days. Reported withdrawal symptoms include:

Xanax is a safe and effective medication when used as directed.

Article last updated by Yvette Brazier on Thu 7 December 2017.Visit our Anxiety / Stress category page for the latest news on this subject, or sign up to our newsletter to receive the latest updates on Anxiety / Stress.All references are available in the References tab.


The TEDS report: Admissions reporting Benzodiazepine and narcotic pain reliever abuse at treatment entry. (2012, December 13). Retrieved from https://www.samhsa.gov/data/sites/default/files/BenzodiazepineAndNarcoticPainRelieverAbuse/BenzodiazepineAndNarcoticPainRelieverAbuse/BenzodiazepineAndNarcoticPainRelieverAbuse.htm

Drug-related hospital emergency room visits. (2011, May).  Retrieved from https://www.drugabuse.gov/publications/drugfacts/drug-related-hospital-emergency-room-visits

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Alprazolam oral tablet is a prescription drug that’s available as the brand-name drugs Alprazolam Intensol, Xanax, or Xanax XR. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.

Alprazolam oral tablets come in immediate-release and extended-release forms, as well as an orally disintegrating form. Alprazolam also comes as a solution. All forms are taken by mouth.

An extended-release drug is released slowly into the bloodstream over time. An immediate-release drug is released into the bloodstream more quickly. The extended-release drug is only used to treat panic disorder.

This drug is used to manage anxiety disorders or panic disorder. It can be used for the short-term relief of symptoms of anxiety, or anxiety linked with depression. Anxiety or tension caused by the stress of everyday life usually doesn’t need to be treated with this drug.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.قرص xanax 0.5

This drug belongs to a class of drugs called benzodiazepines. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug attaches to certain benzodiazepine receptors in your brain and nervous system. This boosts the activity of a chemical called gamma-aminobutyric acid (GABA). This helps to produce a calming effect in your brain.

Alprazolam oral tablet can cause dizziness and drowsiness during the first few hours after you take it. Don’t drive a car or use dangerous machinery until you know how this drug affects you.

This drug can also cause other side effects.

The more common side effects of alprolazam oral tablet can include:

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Alprazolam oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Do not take these drugs with Xanax. When used with Xanax, these drugs can cause dangerous effects in the body. Examples of these drugs include:

Taking alprazolam with certain medications raises your risk of side effects from those drugs. If you take one of these drugs with alprazolam, you may have increased drowsiness. These drugs include:

If you take one of these drugs with alprazolam, you may have increased drowsiness or other side effects.

When used with alprazolam, these drugs can make alprazolam less effective. This means it won’t work as well to treat your condition. This is because the amount of alprazolam in your body is decreased. Examples of these drugs include:

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

This drug may cause a severe allergic reaction. Symptoms can include:

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alprazolam can cause drowsiness, dizziness, or lightheadedness. The use of drinks that contain alcohol raises your risk of these side effects. Try to avoid drinking alcohol while you take this drug.

For people with depression: If you have pre-existing depression, this drug may make your condition worse. If your depression gets worse or you have suicidal thoughts, call your doctor right away.

For people with acute narrow-angle glaucoma: This drug can make your condition worse. Do not take this drug if you have acute narrow-angle glaucoma.

For people with a history of alcoholism, drug abuse, or personality disorder: This drug can lead to physical and psychological dependence (addiction). If you have a history of these conditions, you have a greater risk of dependence on this drug.

For people with liver disease: It may be harder for your body to break down this drug. This can increase the amount of the drug in your body, which can lead to more side effects.

For people with obesity: It may be harder for your body to break down this drug. This can increase the amount of the drug in your body, which can lead to more side effects.

For people with severe lung disease: This drug can make your condition worse. Talk with your doctor about whether this drug is safe for you.

For pregnant women: This drug is a category D pregnancy drug. That means two things:

Talk to your doctor if you’re pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should be only used if the potential risk to the fetus is acceptable given the drug’s potential benefit.

For women who are breastfeeding: This drug may pass into breast milk and may cause side effects in a child who is breastfed. Your child may become lethargic (drowsy) and lose weight. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: If you’re over the age of 65 years, you may be more sensitive to the sedative side effects of this drug. This means you may be more likely to be drowsy. Your doctor should monitor you closely. Also, you should take extra care to avoid falls that may be caused by drowsiness or dizziness.

For children: This medication has not been studied in children. It should not be used in people younger than 18 years.

This dosage information is for alprazolam oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

Generic: Alprazolam

Brand: Xanax

Brand: Alprazolam Intensol

Adult dosage (ages 18–64 years)

قرص xanax 0.5

Immediate-release tablet, orally disintegrating tablet, or oral solution:

Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in people younger than 18 years.

Senior dosage (ages 65 years and older)

Immediate-release tablet, orally disintegrating tablet, or oral solution:

Special considerations

Generic: Alprazolam

Brand: Xanax

Brand: Xanax XR

Brand: Alprazolam Intensol

Adult dosage (ages 18–64 years)

Immediate-release tablet, orally disintegrating tablet, or oral solution:

Extended-release tablet:

Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in people younger than 18 years.

Senior dosage (ages 65 years and older)

Immediate-release tablet, orally disintegrating tablet, or oral solution:

Extended-release tablet:

Special considerations

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.

This drug is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: If you stop taking the drug suddenly, you may have significant withdrawal symptoms. These can include life-threatening symptoms, such as seizures. To avoid withdrawal, your doctor will decrease your dose slowly over time. If you don’t take this drug at all, your symptoms may not improve.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. You may have withdrawal symptoms if you don’t take the drug on schedule.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You should have decreased symptoms of anxiety, or a decrease in panic attacks.

Keep these considerations in mind if your doctor prescribes alprazolam oral tablet for you.

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

When traveling with your medication:

You and your doctor should watch for any problems with your mental health or behavior. This drug can cause new mood and behavior problems, or worsen problems you already have.

Many insurance companies require a prior authorization for this drug. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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