loratadine 10 mg drug interactions - کامل (هلپ کده)

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A total of 88 drugs are known to interact with loratadine.

Show all medications in the database that may interact with loratadine.

Type in a drug name and select a drug from the list.

There is 1 alcohol/food interaction with loratadine

There is 1 disease interaction with loratadine:

loratadine 1 mg drug interactions

Do not stop taking any medications without consulting your healthcare provider.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Some mixtures of medications can lead to serious and even fatal consequences.

Here are 9 ways to stay safe

Urticaria Zyrtec, promethazine, Xolair, cetirizine, Benadryl, Claritin, diphenhydramine, fexofenadine, More

Allergic Rhinitis prednisone, Zyrtec, promethazine, fluticasone nasal, cetirizine, Flonase, montelukast, triamcinolone, More

Allergic Reactions prednisone, promethazine, triamcinolone, Benadryl, diphenhydramine, Phenergan, epinephrine, EpiPen, More

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Drugs.com provides accurate and independent information on more than 24, preion drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated Dec 6th, 218), Cerner Multum™ (updated Dec 7th, 218), Wolters Kluwer™ (updated Dec 5th, 218) and others. To view content sources and ibutions, please refer to our editorial policy.

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A total of 88 drugs are known to interact with Claritin (loratadine).

Show all medications in the database that may interact with Claritin (loratadine).

Type in a drug name and select a drug from the list.

There is 1 alcohol/food interaction with Claritin (loratadine)

There is 1 disease interaction with Claritin (loratadine):

loratadine 1 mg drug interactions

Do not stop taking any medications without consulting your healthcare provider.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Some mixtures of medications can lead to serious and even fatal consequences.

Here are 9 ways to stay safe

Urticaria Zyrtec, promethazine, Xolair, loratadine, cetirizine, Benadryl, diphenhydramine, fexofenadine, doxepin, Phenergan, levocetirizine, Allegra, More

Allergic Rhinitis prednisone, Zyrtec, promethazine, fluticasone nasal, loratadine, cetirizine, Flonase, montelukast, triamcinolone, Benadryl, dexamethasone, More

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Medically reviewed on Feb 2, 218

Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Loratadine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Loratadine is also used to treat skin hives and itching in people with chronic skin reactions.loratadine 1 mg drug interactions

You should not take this medication if you are allergic to loratadine or to desloratadine (Clarinex).

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Loratadine disintegrating tablets (Claritin Reditab) may contain phenylalanine. Talk to your doctor before using this form of loratadine if you have phenylketonuria (PKU).

Ask a doctor or pharmacist before taking this medicine if you have liver or kidney disease.

You should not take this medicine if you are allergic to loratadine or to desloratadine (Clarinex).

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions, especially:

asthma

kidney disease or

liver disease.

Loratadine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Loratadine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Some forms of loratadine may contain phenylalanine. Talk to your doctor before taking loratadine if you have phenylketonuria (PKU).

Do not give this medicine to a child younger than 6 years old without the advice of a doctor.

Use loratadine exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medicine to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Loratadine is usually taken once per day. Follow your doctor’s instructions.

Do not crush, chew, or break the regular tablet. Swallow the pill whole.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

The chewable tablet must be chewed before you swallow it.

To take the orally disintegrating tablet (Claritin RediTab, Alavert):

Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.

Use dry hands to remove the tablet and place it in your mouth.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, or if they get worse.

Store at room temperature away from moisture and heat.

Dosage Information (in more detail)

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-8-222-1222.

Overdose symptoms may include ache, drowsiness, and fast or pounding heartbeat.

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have signs of an allergic reaction to loratadine: hives difficult breathing swelling of your face, lips, tongue, or throat.

Stop using loratadine and call your doctor at once if you have:

fast or uneven heart rate

severe ache or

a light-ed feeling, like you might pass out

loratadine 1 mg drug interactions

Common loratadine side effects may include:

ache

feeling tired or drowsy

stomach pain, vomiting

dry mouth or

feeling nervous or hyperactive.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-8-FDA-188.

Side effects (in more detail)

Usual Adult Dose of Loratadine for Allergic Rhinitis:

1 mg orally once a day

Usual Adult Dose for Urticaria:

1 mg orally once a day

Usual Pediatric Dose for Allergic Rhinitis:

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 1 mg orally once a day (tablets, capsule, and disintegrating tablets)

Usual Pediatric Dose for Urticaria:

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 1 mg orally once a day (tablets, capsule, and disintegrating tablets)

Other drugs may interact with loratadine, including preion and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Drug Interactions (in more detail)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use loratadine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

1996-218 Cerner Multum, Inc. Version: 9.2.

Medical Disclaimer

Other brands: Claritin, Alavert, Claritin Reditabs, Children’s Claritin Allergy

Urticaria Zyrtec, promethazine, Xolair, cetirizine, Benadryl, Claritin, diphenhydramine, fexofenadine, More

Allergic Rhinitis prednisone, Zyrtec, promethazine, fluticasone nasal, cetirizine, Flonase, montelukast, triamcinolone, More

Allergic Reactions prednisone, promethazine, triamcinolone, Benadryl, diphenhydramine, Phenergan, epinephrine, EpiPen, More

Subscribe to free Drugs.com newsletters.

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Subscribe to receive email notifications whenever new articles are published.

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© 2-218 Drugs.com. All rights reserved.

Loratadine, sold under the brand names Claritin and Claritin-D (which contains loratadine plus pseudoephedrine), is an over-the-counter antihistamine medication.

The drug is often used to treat nasal allergies (allergic rhinitis) and hives (urticaria).

Antihistamines work by blocking the release of histamine, a chemical your body naturally produces when it is exposed to something that causes an allergic reaction.

Loratadine was originally approved by the Food and Drug Administration (FDA) in 1993 and was originally manufactured by Bayer Healthcare.loratadine 1 mg drug interactions

People who are allergic to the drug’s active ingredient (loratadine) or any other components in the drug should not take loratadine.

Those born with the rare condition phenylketonuria should also avoid loratadine.

If you have severe kidney disease or poor liver problems, talk to your doctor before taking loratadine.

Loratadine is a pregnancy category B drug, which means it is should not cause harm to an unborn child.

Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this or any other medication.

You should also alert your physician if you are breastfeeding or plan to breastfeed. It’s not recommended that breastfeeding mothers take this medication.

Because loratadine does not tend to cause as much as drowsiness as Benadryl (diphenhydramine), it may be used for dogs with allergies, if your veterinarian approves its use.

Before giving loratadine, make sure that your dog does not have liver disease and is not taking any other antihistamines or medications like cimetidine, erythromycin, or ketoconazole, which may interact with loratadine.

Ask your veterinarian what dose is safe for your dog.

It’s also a good idea to give your dog either only the capsules or tablets because the alcohol in the liquid form of loratadine may be too strong for your dog.

Loratadine is not known to have many major drug interactions.

However, it’s still important to share with your doctor and pharmacist all preion, non-preion, illegal, recreational, herbal, nutritional, or dietary drugs you’re taking.

You should not take loratadine if you are taking Ranexa (ranolazine).

Also, before taking loratadine, first talk to your doctor if you are taking any of the following:

Because both alcohol and loratadine may cause drowsiness, along with dry mouth and dry eyes (which may blur vision), you should avoid drinking alcohol while taking loratadine.

Loratadine and grapefruit juice are both broken down in the liver the same way, so there’s a small chance of adverse effects when both are taken at the same time.

Talk to your doctor or pharmacist about drinking grapefruit juice if you are taking loratadine.

Loratadine comes in capsules, tablets, and as syrup. Loratadine should not be given to children under that age 6.

You should not take more than 1 milligram (mg), which is one tablet or capsule and two teaspoons of syrup a day of loratadine, unless directed by your doctor.

People who take more than the recommended 1 mg of loratadine a day are at greater risk of severe sleepiness, racing heartbeat, and aches.

Children who take more than the recommended 1 mg of loratadine may actually start to move and behave similarly to people who have Parkinson’s disease.

If you suspect an overdose, contact a poison control center or emergency room immediately. You can get in touch with a poison control center at (8) 222-1222.

If you miss a dose of Loratadine, try to take it as soon as you remember.

However, if it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Don’t double up to make up for a missed dose.

A: Medications should not be used past the expiration dating printed on the packaging. Medications can lose potency and/or become unsafe to take once past their expiration date. Always read and follow the complete directions and warnings on over-the-counter medications and discuss their use with your health care provider before using them.

A: According to the available literature, weight gain and “feeling puffy” were not commonly reported side effects of loratadine. If you have been experiencing a feeling of puffiness or unexplained changes in weight, with no changes in diet or activity level, you may want to contact your health care provider to determine the cause. For additional information regarding loratadine you may want to visit our Web site: //www.everydayhealth.com/drugs/loratadine.

A: Loratadine is a “non-drowsy” antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Loratadine is used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose. It’s also used to treat skin hives and itching in people with chronic skin reactions. There are other non-drowsy antihistamines on the market, both as over-the-counter and as preion medications. Some people find that one works better for them than another. If your symptoms persist despite treatment, consult your health care provider. You may also find helpful information at //www.everydayhealth.com/drugs/loratadine. Sarah Lewis, PhamrD

A: Your question concerns possible side effects of Alavert [loratadine]. (//www.everydayhealth.com/drugs/loratadine) Headaches are a frequently occurring minor side effect of Alavert. It is always a good idea to check with one It is always a good idea to check with one..

A: Loratadine is in a class of medications called antihistamines. Loratadine works by blocking the action of histamine, a substance made in the body that causes allergy symptoms. Sometimes sinus aches are caused by allergies. When allergies lead to sinus aches, an antihistamine, like loratadine may be used. Dry nose and dry mouth are side effects reported in some patients who take loratadine however, loratadine is less likely to cause these side effects compared with some other antihistamines.

A: Loratadine (Claritin) is a second generation (non-sedating) antihistamine. Allegra (fexofenadine) is also a second generation (non-sedating) antihistamine. Both are used for the treatment of allergy symptoms. Loratadine and Allegra are in the same class of medications so they are very similar but they are not the same drug. Some patients may respond better to one medication over another or have different side effects when switching from one to another. When your doctor prescribes a new medication, be sure to discuss all your preion and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your preion medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your preion drugs and to advise you about drug interactions and side effects. Tell your health care provider about any negative side effects from preion drugs. You can also report them to the U.S. Food and Drug Administration by visiting www.fda.gov/medwatch or by calling 1-8-FDA-188. Laura Cable, PharmD., BCPS

A: Headaches are a frequently occurring, minor side effect associated with Alavert (loratadine) treatment. It is always a good idea to check with your health care provider if you experience bothersome side effects from a medication. Your doctor may be able to recommend a change in the time of dosage or possibly add a ache medicine to your regimen. Please consult your health care provider for further guidance in your specific case. //www.everydayhealth.com/drugs/loratadine Gregory Latham, RPh

A: As far as blood in the stool, loratadine is not really known to cause this. You may want to talk to your doctor about this so that they can determine the cause. Perhaps a hemorrhoid could be causing the blood, especially since you have been lifting heavy buckets and could have strained the rectum. The best thing would be for you to speak with the doctor. Megan Uehara, PharmD

A: Loratadine (Claritin) is an antihistamine that can be used for the temporary relief of runny nose, sneezing, itchy eyes, watery eyes, and itching in the back of the throat due to hay fever or other upper respiratory allergies. Loratadine works by blocking histamine in the body. Histamine is the chemical in the body responsible for creating the symptoms of allergies. Loratadine may also be used to treat hives. Some of the side effects that may occur with loratadine include ache, fatigue, and dry mouth. Loratadine is dosed once daily. Loratadine can be taken at any time of day, but should only be taken once every 24 hours. Loratadine usually does not cause drowsiness. However, if loratadine is taken more than recommended, drowsiness can occur. People who have kidney disease should consult their health care provider before taking loratadine to see if a dose adjustment may be needed. Women who are pregnant or breastfeeding should consult with a health care provider before using loratadine. Because loratadine is an antihistamine, and may cause lung secretions to become dry, people with breathing difficulties including asthma and chronic obstructive pulmonary disease (COPD) may want to check with their health care provider before taking loratadine. There is no time limit mentioned on how long a person can take loratadine in the medication information. Please consult with your health care provider to see if daily dosing of loratadine is appropriate for you. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD

By Frieda Wiley, PharmD, CGP, RPh | Medically Reviewed by Robert Jasmer, MD

Latest Update: 215-2-27 © 214 Everyday Health Media, LLC

loratadine 1 mg drug interactions

Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Basics, Side Effects, Interactions, and Dosage tabs. The information within the Reviews and FAQ tabs is proprietary to Everyday Health.

You can browse Drugs A-Z for a specific preion or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen.

Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. The drug information above is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(loratadine)

Loratadine belongs to the class of medications called second-generation antihistamines, specifically the class known as histamine receptor antagonists. It works by blocking the action of one of the body’s natural chemicals known as histamine. Histamine is responsible for many of the symptoms caused by allergies.

Loratadine is used for the relief of symptoms associated with seasonal allergies, including sneezing, itchy and runny nose, and tearing and redness of the eyes. It is also used for the relief of symptoms associated with allergic skin conditions, including chronic hives and other skin disorders. Loratadine is also used for the relief of symptoms associated with year-round allergies. Loratadine usually starts working within 2 hours and lasts for 24 hours.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.loratadine 1 mg drug interactions

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What you think is a temporary inconvenience could get in the way of your daily life. Don’t ignore the red flags.

Regular tablets (1 mg)
Each white, oval, shallow, deep-scored tablet, with the flash and dish logo above the score and the number 1 below contains loratadine 1 mg. Nonmedicinal ingredients: cornstarch, lactose, and magnesium stearate.

Rapid Dissolve Tongue Tablets (1 mg)
Each white, round, tablet-shaped unit with a debossed “C1” contains micronized loratadine 1 mg. Nonmedicinal ingredients: citric acid, gelatin, mannitol, and mint flavour.

Claritin Kids Syrup – Fruit Flavour
Each 1 mL of clear, colourless to light yellow, peach-flavoured syrup contains loratadine 1 mg. Nonmedicinal ingredients: artificial peach flavour, citric acid monohydrate, edetate disodium, glycerin, propylene glycol, purified water, sodium benzoate, and sucrose.

If you frequently use over-the-counter drops and are still experiencing bothersome dry eye symptoms, it could be dry eye disease.

Tablets: For adults and children 12 years of age and older, the recommended dose of loratadine is 1 mg once daily. The regular tablets may be taken with or without food. The rapid-dissolving tablets should be taken on an empty stomach. Water or other liquids are not necessary with the rapid-dissolving tablets as they will melt instantly on the tongue.

Capsules: For adults and children 12 years of age and older, the recommended dose of loratadine is 1 mg once daily with water. Syrup: A liquid form of loratadine is available for children 2 years of age and older, as well as adults who are unable to swallow tablets. The recommended dose of loratadine syrup for adults and children over 1 years of age (weighing more than 3 kg) is 1 mL (1 mg) once daily. The recommended dose for children 2 to 9 years of age (weighing 3 kg or less) is 5 mL (5 mg) once daily.

Children between 2 to 12 years of age should not take loratadine for longer than 14 days unless recommended by a doctor. Adults and children over 12 years of age can loratadine for up to 6 months.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as suggested by your doctor or pharmacist. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take more than one dose in 24 hours. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Do not use this mediction if you are allergic to loratadine or to any of the ingredients of the medication.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Stop taking the medication and seek immediate medical attention if any of the following occur:

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.

Drowsiness: Loratadine usually causes minimal drowsiness when used as directed by your doctor or pharmacist. If you are taking higher-than-recommended doses of loratadine, you may experience drowsiness. Do not drive or operate machinery if you become drowsy while taking this medication.

Liver problems: If you have reduced liver , discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. People with severely reduced liver should take a lower dose (5 mg once daily or 1 mg every other day) of this medication.

Pregnancy: The safety of using this medication during pregnancy has not been established. Women who are pregnant should not use this medication. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: The safety of loratadine has not been established for women who are breast-feeding. Women who are breast-feeding should not take loratadine.

Children: The safety and effectiveness of using this medication have not been established for children younger than 2 years of age. For children between the ages of 2 and 12, do not give this medication for longer than 14 days, unless recommended by a doctor.

There may be an interaction between loratadine and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all preion, over-the-counter (non-preion), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 218. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Claritin

Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness.

A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).

Loratadine is a long acting second generation antihistamine that is similar in structure to cyproheptadine and azatadine. The pharmacology of loratadine is similar to other antihistamines, but unlike other H1-blockers, loratidine is shown to exhibit competitive, specific, and selective antagonism of H1 receptors. The exact mechanism of this interaction is unknown, but disposition of the drug suggests that loratadine’s prolonged antagonism of histamine may be due to the drug’s slow dissociation from the receptor or the formation of the active metabolite, desloratadine. Loratadine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.

Loratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Loratadine has low affinity for cholinergic receptors and does not exhibit any appreciable alpha-adrenergic blocking activity in-vitro. Loratadine also appears to suppress the release of histamine and leukotrienes from animal mast cells, and the release of leukotrienes from human lung fragments, although the clinical importance of this is unknown.

Rapidly absorbed following oral administration (4% bioavailability)

loratadine 1 mg drug interactions

97-99%

Hepatic

8.4 hours

somnolence, tachycardia, and ache LD5mg/kg (orally in rat)

Alberto Stampa, Pelayo Camps, Gloria Rodriguez, Jordi Bosch, Maria del Carmen Onrubia, “Process for the preparation of loratadine.” U.S. Patent US6841, issued July 4, 2.

Drug created on June 13, 25 7:24 / Updated on December 12, 218 7:4

(loratadine)

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What you think is a temporary inconvenience could get in the way of your daily life. Don’t ignore the red flags.

Each white, oval, biconvex tablet, scored and engraved “LO” over “1” on one side and “APO” on the other, contains loratadine 1 mg (as base). Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, magnesium stearate, and microcrystalline cellulose.