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خواص دارویی و گیاهی

مدپلاس

کواتیاپین (Quetiapine) با نام تجاری سروکوئل (SEROquel) یک داروی ضد جنون می باشد که با تغییر اعمال مواد شیمیایی در مغز کار می کند.

کواتیاپین برای درمان بیماران اسکیزوفرنی در کودکان و بزرگسالان که حداقل 13 سال سن دارند استفاده می شود.

کواتیاپین همچنین برای درمان اختلال دو قطبی (افسردگی شیدایی) در کودکان و بزرگسالان که حداقل 10 سال سن دارند مورد استفاده قرار می گیرد.

کواتیاپین ممکن است همراه با داروهای ضد افسردگی مورد استفاده در درمان اختلال افسردگی اساسی در بزرگسالان قرار گیرد.

کواتیاپین طولانی رهش به نام سروکوئل ایکس آر (Seroquel XR) برای استفاده تنها در بزرگسالان بالاتر از 18 سال تجویز می شود.

کواتیاپین برای درمان مشکلات روانی ناشی از زوال عقل مورد تایید نیست .

کواتیاپین برای استفاده در تمام کودکان مورد تایید نمی باشد٬ اگر پزشک شما برای برای کودک شما کواتیاپین تجویز کرده است، با دکتر صحبت کنید تا مطمئن شوید که کواتیاپین برای کودک شما مناسب است.

نام ژنریک: کواتیاپین (Quetiapine)

نام تجاری: سروکوئل ایکس آر (Seroquel XR) و سروکوئل (SEROquel)

کلاس درمانی: آنتی سایکوتیک ٬ ضد جنون

کلاس شیمی: کواتیاپین

مطمئن شوید که شما با خیال آسوده می توانید این دارو را استفاده نمایید، اگر شما دارای هر یک از شرایط زیر می باشید با پزشک خود در جریان بگذارید :

بیماری کبد و یا کلیوی.
بیماری های قلبی، اختلالات ریتم قلبی، سابقه حمله قلبی یا سکته مغزی.
فشار خون بالا و یا پایین.
سابقه کمبود سلول های سفید خون (WBC)، .
تست های تیروئید غیر طبیعی و یا سطح پرولاکتین.
تشنج یا صرع؛
آب مروارید.
کلسترول بالا و یا تری گلیسرید.
سابقه شخصی یا خانوادگی ابتلا به دیابت.
مشکل در بلع.

مصرف داروهای ضد جنون در 3 ماه آخر بارداری ممکن است مشکلات را در نوزاد بوجود آورد٬ قبل از مصرف این دارو در دوران بارداری با پزشک خود مشورت نمایید

اگر شما در حالی که کواتیاپین مصرف می کنید باردار شدید ، از متوقف آن بدون مشورت دکتر خودداری نمایید ٬ از جمله نشانه های ترک دارو ، اختلالات تنفسی ، مشکلات تغذیه ، ایراد گیری کردن ، لرزش ، و عضلات شل یا سفت می باشد. با این حال، شما ممکن است بعد از ترک دارو مشکلات دیگری در دوران بارداری برای شما بوجود آید٬ به همین خاطر در صورت بارداری هرگز این دارو را بدون مشورت پزشک خود قطع نکنید .

کواتیاپین می تواند به شیر مادر منتقل شود و به کودک شیرخوار آسیب برساند. شما نباید در دوران شیردهی از این دارو استفاده نمایید .

اگر شما پس از مصرف این دارو دچار هر یک از عارضه های جدی زیر شدید٬ با پزشک خود تماس گرفته و او را در جریان قرار دهید .

احساس سبکی سر ،
عضلات بسیار سفت ( سفت و سخت ) ، تب بالا، عرق کردن ، گیجی، ضربان قلب سریع یا ناهموار، لرزش .
کشش و یا غیر قابل کنترل حرکات چشم، لبها، زبان ، صورت، بازوها و یا پاها .
بلع مشکل ،
تورم پستان یا ترشحات ( در مردان و زنان ) ، از دست رفته دوره قاعدگی ، ناتوانی جنسی ، کاهش میل جنسی .
تاری دید، تونل دید ، درد چشم، یا دیدن هاله در اطراف چراغ .
ضعف ناگهانی و یا احساس ناخوشی ، تب، لرز، علائم سرماخوردگی و آنفلوآنزا ، سرفه ، گلو درد، لثه قرمز و متورم ، زخم های دردناک دهان ، زخم های پوست، تنفس مشکل

سرگیجه، خواب آلودگی ، از دست دادن انرژی، احساس خستگی .
افزایش اشتها، افزایش وزن .
خشکی دهان .
تهوع، استفراغ ، درد معده یا ناراحتی ، یبوست .

قبل از مصرف کواتیاپین با قرص خواب، داروهای درد مخدر، relaxer عضلانی، و یا دارو برای اضطراب، افسردگی، یا تشنج با پزشک خود مشورت نمایید .
بسیاری از داروها می تواند با کواتیاپین تداخل ایجاد کنند. همه فعل و انفعالات که اینجا ذکر شده است امکان پذیر نمی باشند٬ در هر صورت در مورد تمام داروهایی که استفاده می نمایید با پزشک خود در جریان بگذارید ٬ از جمله داروهای زیر :

lumefantrine، متوکلوپرامید، mifepristone.
داروهای ضد سرطان – تری اکسید آرسنیک، bexarotene، nilotinib، toremifene، vandetanib، vemurafenib. داروهای ریتم قلب – آمیودارون، disopyramide، dofetilide، درونیدرونات، flecainide، پروکائین آمید، quinidine، sotalol. داروهای HIV / AIDS – ریتوناویر، ساکوییناویر. دارو برای درمان بیماری های روانی – iloperidone، پیموزاید، thioridazine، زیپرازیدون.

مطلب قبلی

پالیویزوماب Palivizumab

مطلب بعدی

لیراگلوتاید Liraglutide

آلپرازولام Alprazolam

آمپی سیلین

جنتامایسین

کلرامفنيکل | Chloramphenicol

تهیه روغن گل سرخ در خانه

وانکومایسین | Vancomycin

سلام اقای دکتر بنده ۳۸ سالمه از ساله ۹۱ تا الان شبی ۱ عدد کوتیاپین ۱۰۰ میخورم.ساعت خوابم کمتر شده و دچاره تشنجها و خفگی های مداوم در هر شب میشم.۳ تا قرص دیگه هم میخوردم که خودسرانه اونها رو در طی این چند سال حذف کردم.(سیتالوپرام.پرفنازین.دپاکین)آیا راهی هست که بتونم این قرص رو هم اصلا نخورم؟ یا دوزش رو کم کنم؟ یا اینکه بخوام یکباره این قرص رو نخورم مشکلی پیش میاد؟

سلام کوتیاپین داروی خوبیه واسه اضطراب ووسواس همراه فلووکسامین مصرف بشه محشره دوستان

با سلام جواني هستم 20 ساله مدت دو سال هست كه ترانكوپين 25 مصرف ميكنم چون شب ها خوابم نميبره ايا ترانكوپين ارامبخشه؟؟؟و اينكه ميشه مصرفو ادامه بدم يا نه؟؟؟

با تشكر

سلام .
ترانکوپین برای اختلال خواب هم تجویز میشه ولی باید نوع اختلال خواب و به عبارتی دلیلش مشخص بشه و با توجه به اون قرص تجویز بشه .
بهر حال توصیه میکنم در جهت پیدا کردن علت بیخوابی به پزشک مناسب مراجعه کنید مثل یک روانشناس . نمیشه تا آخر عمر برای بیخوابی دارو مصرف کرد . هیچ دارویی بدون عوارض نیست .

sallam aghaye doctor bebakhshid ke man ba horofe englissi minevisam faghat be khatere ine ke man dar khareg az keshvar zendegi mikonam modati dar bimarestan bastari bodam bad onha mano ba skizofereni diagnos kardan montaha behem bad goftan ke in skizofereni nist va in ptsd hast badesh chand ta daro onja masraf kardam baes shod ke ye seri moshkelat baram ijad beshe esmeshon risperdal va olanzapin va haldol bod mad yek hafte mobtala be ye seri moshkelat shodam tavahom halocination va moshkelat jensi harakate gheire eradi dast va pa bad docktor be man Quetiapine tajviz kard vali hanoz man moshkel daram bazi vaght ha tavahom migire mano mikhastam bedonam aya in ghabele bargasht hast ya na

با سلام و وقت بخیر..
بنده شبها خوابم نمیبرد و از یه بیماری به نام ثبات خلقی که ظاهراً طیفی از اختلال دوقطبی هست رنج میبردم…
دکتربنده.. یه تا قرص دپاکین، کویتایپین، و قرص استرس پروپرانول بهم داد که هر شب بخورم…
هر جایی که سوال میکردم به هیچ وجه بهم توصیه نکردند که قرص دپاکین ر مصرف کنم.. به خاطر عوارض بسیار بدش…برای همین میخوام بدونم که اون دو قرص رو بدون قرص اولی آیا مصرف بشه مشکلی به ووجود میاره؟؟
بسیار سپاسگذارم

قرص quetiapine برای چیست

باسلام و احترام
موضوع عالیه سوالی که داشتم این است که من دپاکین رسپیریدون و فلوواکسامین شبا مصرف میکنم و ظهرها نصف کوتیاپین اما این دارو به شدت باعث خواب الودگی من میشه در طول روز وکارهامو مختل کرده ایا میتونم کوتیاپین رو با یکی از داروهایی که شب مصرف میکنم جا به جا کنم یعنی شب بخورم بسیار ممنون و سپاسگذار

بله شما ميتونيد اون رو همراه قرص هاي شبتون ميل كنيد و البته درس و علميش اين است كه همراه بااون داروها مصرف بشه چون كه اين دارو ثابت نگهداره موده اعصاب است و همزمان مصرف بشه بهتره و لازم به ذكر هست كه با مشورت پزشك ميتونيد يك چهارم در شب مصرف كنيد چون بسيار خواب اوره

مريض تنها مجاز به دريافت اطلاعات دارويي از داروساز يا پزشك معالج خود است،
منظور از مشورت با ارايه دهنده ي مراقبت هاي بهداشتي شخصي بجز اين دو فرد است؟

با سلام
منظور از ارائه دهنده مراقبت های بهداشتی ‌پزشک معالج هست٬ فردی که از مجوز لازم برای تجویز دارو برخوردار باشد.

ایمیل شما نمایش داده نخواهد شد

مشخصات من را ذخیره کن

کد کپچا *

دریافت مطالب جدید , اخبار و اطلاعیه ها در ایمیل شما

از عضویت شما سپاسگذاریم . ایمیل خود را جهت تایید بررسی کنید

مطالب تصادفی

رشد کودکان محتاج کدام مواد غذایی است؟

اسطوخودوس

دانستنی های شستن و حمام کردن کودکان

درمان جوش های زیر پوستی

نکاتی در مورد اسهال و استفراغ کودکان

خواص مختلف رنگ های انگور

درمان تنبلی کبد با کاسنی

راه هایی برای درمان هموروئید یا بواسیر

جلوگیری از چروک پوست با مصرف این ۱۰ ماده غذایی

عوارض استفاده از لنز رنگی

کودک و ابهامات جنسی

کاهش خطر بیماری قلبی با رژیم گیاه خواری

در فصل تابستان کودکان را در ماشین تنها نگذارید

نکات ساده غذایی برای کاهش وزن زیاد

نحوه ی تربیت کودک،نباید این جملات را به کودک…

تسکین دردهای مفصلی با طب سنتی

5 اشتباه بزرگ در مورد رژیم غذایی و آرتروز

بدون قرص خارش و عطسه‌های بهاری را درمان کنید

آنچه والدين بايد درباره بلوغ فرزندشان بدانند

زمانی که سیســتم ایمنی پیام هــای غلطی را به پوســت می فرســتد و باعث رشــد بیشتر ســلول های آن می شــود؛ چندین لایه ســلول مرده به شکل پوســته های ســفید رنگ در سطح پوست تجمع پیدا می کنند.

(بیشتر بخوانید : پسوریازیس )

مجری طرح پایلوت : انجمن داروسازان اصفهان

تحت نظارت معاونت غذا و دارو

مسئولیت صحت اطلاعات بر عهده داروخانه می باشد

*دریافت دارو فقط بصورت حضوری در محل داروخانه و با نسخه کامل امکان پذیر است*

کوتیاپین چیست؟
قرص کوتیاپین برای کنترل و درمان بیماری های خلقی، نارحتی های اعصاب مانند شیزوفرنی، دوقطبی، مانیا یا افسردگی کاربرد دارد.

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( سایکوئل محصول شرکت تهران شیمی )

کوتیاپین باعث تنظیم واسطه های شیمیایی خاصی در مغز می گردد. این دارو می تواند حالت هالوسینوژن را برطرف کند و تمرکز را در این بیماران افزایش دهد، کمک می کند که بیمار احساس بهتری نسبت به خود داشته باشد و تا حدودی به شرایط محیط کمتر واکنش عصبی نشان دهد، مشکلات خواب و اشتها را بهبود می بخشد. کوتیاپین می تواند زندگی مفید بیماران مبتلا به شیزوفرنی را ارتقاء دهد.

توصیه های مصرف کوتیاپین
دارو را دقیقا مطابق دستور پزشک مصرف کنید و هر روز در زمانی مشخص (ترجیحا موقع خواب) میل کنید.
قبل از مصرف دارو کلیه داروهای مصرفی خود را به پزشک یا داروساز اطلاع دهید تا از تداخلات احتمالی پیشگیری شود.
این دارو می تواند اثر کاهش فشار خون سایر داروهای فشار خون را افزایش دهد.
برای کاهش عوارض جانبی دارو و افزایش تحمل بدن، معمولا تجویز دارو با کمترین مقدار آغاز و به تدریجا افزایش می یابد. همچنین ممکن است یک تا دو هفته زمان لازم باشد تا اثربخشی دارو آشکار شود بنابراین دوره درمان دارو را طبق دستور پزشک ادامه دهید.

عوارض جانبی کوتیاپین
یبوست، مشکلات گوارشی، گیجی، اضافه وزن، تاری دید و خشکی دهان از عوارض معمولی این دارو است.
بعضی از عوارض بسیار نادر ( ۷ در میلیون ) ممکن است با مصرف این دارو ایجاد شود (سندرم استیونس جانسون) که با زخم هایی در دهان یا روی پوست همراه با تب یا بدون تب مشاهده شود. در یان صورت دارو را فورا قطع کنید و به پزشک اطلاع دهید.

Reference: www.webmd.com

چنانچه در خصوص “کوتیاپین ” سوالی دارید، عارضه خاصی مشاهده نموده اید و یا مطلب ویژه ای به نظرتان می رسد با دیگران به اشتراک بگذارید

قرص کوتیاپین (ترانکوپین) برای کنترل و درمان بیماری های خلقی، ناراحتی های اعصاب مانند شیزوفرنی، دوقطبی، مانیا یا افسردگی کاربرد دارد.
کوتیاپین باعث تنظیم واسطه های شیمیایی خاصی در مغز می گردد. این دارو می تواند حالت هالوسینوژن را برطرف کند و تمرکز را در این بیماران افزایش دهد، کمک می کند که بیمار احساس بهتری نسبت به خود داشته باشد و تا حدودی به شرایط محیط کمتر واکنش عصبی نشان دهد، مشکلات خواب و اشتها را بهبود می بخشد. کوتیاپین می تواند زندگی مفید بیماران مبتلا به شیزوفرنی را ارتقاء دهد.

نام تجاری: Seroquel, Seroquel XR , Ketipin, Bioquetin, Quemind , Quentiax , Quepin

بی خوابی , اسکیزوفرنی , درمان کمکی ترک وابستگی به الکل , اختلالات دو قطبی مانیا , اختلالات دو قطبی همراه با دوره های افسردگی , اختلالات دو قطبی متوسط تا شدید

کوتیاپین علایم مثبت و منفی اختلالات سایکوتیک را از طریق آنتاگونیزه کردن گیرنده های انتقال دهنده های عصبی مختلف مغزی که شامل گیرندهD1 و D2 دوپامین ، گیرنده هیستامین H1 ، گیرنده آدرنرژیک آلفا یک و آلفا دو و انواع گیرنده های 1 و 2 سرتونینی ( 5HT1A و 5HT2 ) هستند، کاهش می دهد .
این دارو بر روی گیرنده های بنزودیازپنی و موسکارینی کولیزژیک تاثیری ندارد .

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جذب : فراهمی زیستی دارو 100 درصد می باشد ( در محلول های خوراکی )
زمان حداکثرغلظت پلاسمایی : انواع سریع رهش : 5/1 ساعت ، انواع پیوسته رهش : 6 ساعت
توزیع : اتصال به پرونین های پلاسما : 83 درصد و حجم توزیع دارو 6 تا 14 لیتر به ازای هر 1 کیلوگرم وزن بدناست .
متابولیسم : این دارو توسط آنزیم C2P3A4 در کبد متابولیزه می شود .
دفع : نیمه عمر دارو در انواع سریع رهش : 6 ساعت و در انواع پیوسته رهش 7 ساعت است .
دارو به میزان 73 درصد از طریق ادرار و به میزان 20 درصد از طریق مدفوع ، دفع می شود .

بزرگسالان: در درمان اسکیزوفرنی در روز اول 25 میلی گرم دو بار در روز, در روز دوم 50 میلی گرم دو بار در روز، در روز سوم 100 میلی گرم دو بار در روز و در روز چهارم 150 میلی گرم دو بار در روز مصرف می شود.

در درمان مانیا در روز اول 50میلی گرم دو بار در روز، در روز دوم 100میلی گرم دو بار در روز، در روز سوم 150میلی گرم دو بار در روز و در روز چهارم 200میلی گرم دو بار در روز مصرف می شود.

کوتیاپین در دوران بارداری جزء گروه C است و ممکن است به جنین آسیب برساند. در صورت شک به بارداری یا برنامه ریزی برای آن پزشک خود را مطلع سازید.

مشخص نیست که کوتیاپین به شیر وارد می شود یا خیر و به کودک شیرخوار آسیب می رساند یا خیر. اگر شما به کودک خود شیر می دهید بدون مشورت با پزشک خود این دارو را مصرف نکنید.

در صورتی که یک نوبت از مصرف کوتیاپین را فراموش کردید به محض به یاد آوردن آن دارو را میل کنید ولی اگر تقریبا زمان مصرف نوبت بعدی فرارسیده باشد فقط آن نوبت را مصرف کنید و از دوبرابر کردن دارو خودداری کنید.

عوارض خطرناک شامل:

عوارض خفیف شامل:

این لیست کامل نیست و ممکن است عوارض دیگری اتفاق بیفتد. درباره تمام عوارض ناخواسته و مزاحم با پزشک خود صحبت کنید.

اگر شما هرکدام از داروهای زیر را مصرف می کنید قبل از مصرف کوئتیاپین پزشک خود را مطلع سازید:

این لیست کامل نیست و ممکن است داروهای دیگری وجود داشته باشند که با کوئتیاپین تداخل پیدا کنند. درباره تمام داروهای بدون نسخه و یا با نسخه ای که مصرف می کنید به پزشک خود اطلاع دهید. این توصیه داروهای گیاهی، ویتامین ها و دیگر داروها را نیز دربر می گیرد.

1- کوتیاپین را ترجیحاٌ در عصر قبل از غذا یا همراه با یک وعده غذای سبک مصرف نمایید .
2- داروی کوتیاپین سریع رهش را به داروی پیوسته رهش تغییر دهید .
3- برای معادل سازی قرص های پیوسته رهش با سریع رهش دوز کلی روزانه به صورت زیر است : یکبار در روز تجویز می شود که ممکن است تنظیم دوز فردی نیز نیاز باشد .

بیشتر بخوانید:

آرام کردن اعصاب،چگونه اعصاب خود را آرام کنیم؟

برای آرامش اعصاب و روان خود گل گاو زبان بخورید

9 روز مبارزه برای درمان اعصاب همیشه خورد شما!

شیزوفرنی (اسکیزوفرنی) چیست و چه علائمی دارد؟

گردآوری توسط بخش سلامت

مجله دلگرم

Quetiapine, sold under the trade name Seroquel among others, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.[6][7] Although not recommended, it is also used as a sleep aid due to its sedating effect.[8] It is taken by mouth.[6]

Common side effects include sleepiness, constipation, weight gain, and dry mouth.[6] Other side effects include low blood pressure with standing, seizures, a prolonged erection, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome.[6] In older people with dementia, its use increases the risk of death.[6] Use in the third trimester of pregnancy may result in a movement disorder in the baby for some time after birth.[6] Quetiapine is believed to work by blocking a number of receptors including serotonin and dopamine.[6]

Quetiapine was developed in 1985 and approved for medical use in the United States in 1997.[6][9] It is available as a generic medication.[10] In the United States, the wholesale cost is about US$12 per month as of 2017.[11] In the United Kingdom, a month’s supply costs the NHS about £60 as of 2017.[10] In 2016, it was the 86th most prescribed medication in the United States, with more than 8 million prescriptions.[12]

Quetiapine is primarily used to treat schizophrenia or bipolar disorder.[13] Quitapine targets both positive and negative symptoms of schizophrenia.[14]

قرص quetiapine برای چیست

A 2013 Cochrane review compared quetiapine to typical antipsychotics:

In a 2013 comparison of 15 antipsychotics in effectiveness in treating schizophrenia, quetiapine demonstrated standard effectiveness. It was 13-16% more effective than ziprasidone, chlorpromazine, and asenapine and approximately as effective as haloperidol and aripiprazole.[16]

There is tentative evidence of the benefit of quetiapine versus placebo in schizophrenia; however, definitive conclusions are not possible due to the high rate of attrition in trials (greater than 50%) and the lack of data on economic outcomes, social functioning, or quality of life.[17]

It is debatable whether, as a class, typical or atypical antipsychotics are more effective.[18] Both have equal drop-out and symptom relapse rates when typicals are used at low to moderate dosages.[19] While quetiapine has lower rates of extrapyramidal side effects, there is greater sleepiness and rates of dry mouth.[17]

A Cochrane review comparing quetiapine to other atypical antipsychotic agents tentatively concluded that it may be less efficacious than olanzapine and risperidone; produce fewer movement related side effects than paliperidone, aripiprazole, ziprasidone, risperidone and olanzapine; and produce weight gain similar to risperidone, clozapine and aripiprazole. They concluded that it produces suicide attempt, suicide; death; QTc prolongation, low blood pressure; tachycardia; sedation; gynaecomastia; galactorrhoea, menstrual irregularity and white blood cell count at a rate similar to first generation antipsychotics.[20]

In those with bipolar disorder, quetiapine is used to treat depressive episodes; acute manic episodes associated with bipolar I disorder (as either monotherapy or adjunct therapy to lithium; valproate or lamotrigine); and maintenance treatment of bipolar I disorder (as adjunct therapy to lithium or divalproex).

Quetiapine is effective when used by itself[7] and when used along with other medications in major depressive disorder (MDD).[7][21] However, sedation is often an undesirable side effect.[7]

In the United States,[4] the United Kingdom[22] and Australia (while not subsidised by the Australian Pharmaceutical Benefits Scheme for treatment of MDD), quetiapine is licensed for use as an add-on treatment in MDD.[23]

Quetiapine does not decrease agitation among people with Alzheimer’s. Quetiapine worsens intellectual functioning in the elderly with dementia and therefore is not recommended.[24]

The use of low doses of quetiapine for insomnia, while common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects.[25][26]

It is sometimes used off-label, often as an augmentation agent, to treat conditions such as Tourette syndrome,[27] musical hallucinations[28] and anxiety disorders.[29]

Quetiapine and clozapine are the most widely used medications for the treatment of Parkinson’s disease psychosis due to their very low extrapyramidal side-effect liability. Owing to the risks associated with clozapine (e.g. agranulocytosis, diabetes mellitus, etc.), clinicians often attempt treatment with quetiapine first, although the evidence to support quetiapine’s use for this indication is significantly weaker than that of clozapine.[30][31]

Sources for incidence lists:[2][4][22][23][31][32]

Both typical and atypical antipsychotics can cause tardive dyskinesia.[34] According to one study, rates are lower with the atypicals at 3.9% as opposed to the typicals at 5.5%.[34] Although quetiapine and clozapine are atypical antipsychotics, switching to these atypicals is an option to minimize symptoms of tardive dyskinesia caused by other atypicals.[35]

Weight gain can be a problem for some, with quetiapine causing more weight gain than fluphenazine, haloperidol, loxapine, molindone, olanzapine, pimozide, risperidone, thioridazine, thiothixene, trifluoperazine, and ziprasidone, but less than chlorpromazine, clozapine, perphenazine, and sertindole.[36]

Studies conducted on beagles have resulted in the formation of cataracts. While there are reports of cataracts occurring in humans, controlled studies including thousands of patients have not demonstrated a clear causal association between quetiapine therapy and this side-effect.[citation needed] However, the Seroquel website[37] still recommends users have eye examinations every six months.

As with some other anti-psychotics, quetiapine may lower the seizure threshold,[38] and should be taken with caution in combination with drugs such as bupropion.

Quetiapine should be discontinued gradually, with careful consideration from the prescribing doctor, to avoid withdrawal symptoms or relapse.

The British National Formulary recommends a gradual withdrawal when discontinuing anti-psychotic treatment to avoid acute withdrawal syndrome or rapid relapse.[39] Due to compensatory changes at dopamine, serotonin, adrenergic and histamine receptor sites in the central nervous system, withdrawal symptoms can occur during abrupt or over-rapid reduction in dosage. However, despite increasing demand for safe and effective antipsychotic withdrawal protocols or dose-reduction schedules, no specific guidelines with proven safety and efficacy are currently available.

Withdrawal symptoms reported to occur after discontinuation of antipsychotics include nausea; emesis; lightheadedness; diaphoresis; dyskinesia; orthostatic hypotension; tachycardia; insomnia; nervousness; dizziness; headache; non-stop crying; and anxiety.[40][41] Some have argued that additional somatic and psychiatric symptoms associated with dopaminergic super-sensitivity, including dyskinesia and acute psychosis, are common features of withdrawal in individuals treated with neuroleptics.[42][43] The present evidence suggests that these symptoms affect a small number of susceptible individuals treated with quetiapine.[40]

Placental exposure is least for quetiapine compared to other atypical antipsychotics.[31] The evidence is insufficient to rule out any risk to the foetus but available data suggests it is unlikely to result in any major foetal malformations.[3][5][32] It is secreted in breast milk and hence quetiapine-treated mothers are advised not to breastfeed.[3][5][32]

Most instances of acute overdosage result in only sedation, hypotension and tachycardia, but cardiac arrhythmia, coma and death have occurred in adults. Serum or plasma quetiapine concentrations are usually in the 1–10 mg/L range in overdose survivors, while postmortem blood levels of 10–25 mg/L are generally observed in fatal cases.[44] Non-toxic levels in postmortem blood extend to around 0.8 mg/kg, but toxic levels in postmortem blood can begin at 0.35 mg/kg.[45][46]

Quetiapine has the following pharmacological actions:[50][51][52][53][54][55][56][57]

This means quetiapine is a dopamine, serotonin, and adrenergic antagonist, and a potent antihistamine with some anticholinergic properties.[58] Quetiapine binds strongly to serotonin receptors; the drug acts as partial agonist at 5-HT1A receptors.[59] Serial PET scans evaluating the D2 receptor occupancy of quetiapine have demonstrated that quetiapine very rapidly disassociates from the D2 receptor.[60] Theoretically, this allows for normal physiological surges of dopamine to elicit normal effects in areas such as the nigrostriatal and tuberoinfundibular pathways, thus minimizing the risk of side-effects such as pseudo-parkinsonism as well as elevations in prolactin.[61] Some of the antagonized receptors (serotonin, norepinephrine) are actually autoreceptors whose blockade tends to increase the release of neurotransmitters.

At very low doses, quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker. When the dose is increased, quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors. At high doses, quetiapine starts blocking significant amounts of dopamine receptors.[62][63] Off-label prescriptions, e.g. for chronic insomnia, of low-dose quetiapine is not recommended due to the harmful side-effects.[64]

When treating schizophrenia, antagonism of D2 receptor by quetiapine in the mesolimbic pathway relieves positive symptoms and antagonism of the 5HT2A receptor in the frontal cortex of the brain relieves negative symptoms. [65][66][67] Quetiapine has fewer extrapyramidal side effects and is less likely to cause hyperprolactinemia when compared to other drugs used to treat schizophrenia, so is used as a first line treatment.[68][69]

The major active metabolite of quetiapine is norquetiapine (N-desalkylquetiapine).[48] Quetiapine has a half-life of 7 hours. It is excreted primarily via the kidneys (73%) and in faeces (20%) after hepatic metabolism, the remainder (1%) is excreted as the drug in its unmetabolized form.[70][71]

Quetiapine is a tetracyclic compound and is closely related structurally to clozapine, olanzapine, loxapine, and other tetracyclic antipsychotics.

The synthesis of quetiapine begins with a dibenzothiazepinone. The lactam is first treated with phosphoryl chloride to produce a dibenzothiazepine. A nucleophilic substitution is used to introduce the sidechain.[72]

AstraZeneca submitted a new drug application for a sustained-release version of quetiapine in the United States, Canada, and the European Union in the second half of 2006 for treatment of schizophrenia.[73][74] AstraZeneca was to retain the exclusive right to market sustained-release quetiapine until 2017. The sustained-release quetiapine is marketed mainly as Seroquel XR. Other marketing names are Seroquel Prolong, Seroquel Depot and Seroquel XL

On May 18, 2007, AstraZeneca announced that the U.S. FDA approved Seroquel XR for acute treatment of schizophrenia.[75] During its 2007 Q2 earnings conference, AstraZeneca announced plans to launch Seroquel XR in the U.S. during August 2007.[76] However, Seroquel XR has become available in U.S. pharmacies only after the FDA approved Seroquel XR for use as maintenance treatment for schizophrenia, in addition to acute treatment of the illness, on November 16, 2007.[77] The company has not provided a reason for the delay of Seroquel XR’s launch.

Health Canada approved sale of Seroquel XR on September 27, 2007.[78]

In early October 2008, the FDA approved Seroquel XR for the treatment of bipolar depression and bipolar mania. According to AstraZeneca, Seroquel XR is “the first medication approved by the FDA for the once-daily acute treatment of both depressive and manic episodes associated with bipolar.”

On July 31, 2008, Handa Pharmaceuticals, based in Fremont, California, announced that its abbreviated new drug application (“ANDA”) for quetiapine fumarate extended-release tablets, the generic version of AstraZeneca’s SEROQUEL XR, has been accepted by the FDA.

On December 1, 2008, Biovail announced that the FDA had accepted the company’s ANDA to market its own version of sustained-release quetiapine.[79] Biovail’s sustained-release tablets will compete with AstraZeneca’s Seroquel XR.

قرص quetiapine برای چیست

On December 24, 2008, AstraZeneca notified shareholders that the FDA had asked for additional information on the company’s application to expand the use of sustained-release quetiapine for treatment of depression.[80]

In the United States, the Food and Drug Administration (FDA) has approved quetiapine for the treatment of schizophrenia and of acute manic episodes associated with bipolar disorder (bipolar mania) and for treatment of bipolar depression.[81] In 2009, quetiapine XR was approved as adjunctive treatment of major depressive disorder.[82]

Quetiapine received its initial indication from U.S. FDA for treatment of schizophrenia in 1997.[83] In 2004, it received its second indication for the treatment of mania-associated bipolar disorder.[84] In 2007 and 2008, studies were conducted on quetiapine’s efficacy in treating generalized anxiety disorder and major depression.

Patent protection for the product ended in 2012; however, in a number of regions, the long-acting version remained under patent until 2017.[85]

In the United States as of 2015, the branded extended-release 400 mg pills cost between US$9.68 and US$23.16 each.[86] In 2017, the short-acting version had a wholesale cost of about US$12 per month.[11]

In the United Kingdom, a month’s supply, as of 2017, costs the NHS approximately £107.45.[10] This is following an increase of 30 to 70 fold in 2017/2018.[87]

In April 2010, the U. S. Department of Justice fined Astra-Zeneca $520 million for the company’s aggressive marketing of Seroquel for off-label uses.[81] According to the Department of Justice, “the company recruited doctors to serve as authors of articles that were ghostwritten by medical literature companies and about studies the doctors in question did not conduct. AstraZeneca then used those studies and articles as the basis for promotional messages about unapproved uses of Seroquel.”[81]

Multiple lawsuits have been filed in relation to quetiapine’s side-effects, in particular, diabetes.[88][89][90][91]

Approximately 10,000[92] lawsuits[93] have been filed against AstraZeneca, alleging that quetiapine caused problems ranging from slurred speech and chronic insomnia to deaths.

In 2004, a young man named Dan Markingson committed suicide in a controversial Seroquel clinical trial at the University of Minnesota while under an involuntary commitment order.[94] A group of University of Minnesota bioethicists charged that the trial involved an alarming number of ethical violations.[95]

In August 2011, the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) issued a class-4 drug alert following reports that some batches of Nurofen plus contained Seroquel XL instead.[96]

Following the issue of the Class-4 Drug Alert, Reckitt Benckiser (UK) Ltd received further reports of rogue blister strips in cartons of two additional batches of Nurofen Plus tablets. One of the new batches contained Seroquel XL 50 mg tablets and one contained the Pfizer product Neurontin 100 mg capsules.

Following discussions with the MHRA’s Defective Medicines Report Centre (DMRC), Reckitt Benckiser (UK) Ltd decided to recall all remaining unexpired stock of Nurofen Plus tablets in any pack size, leading to a Class-1 Drug Alert.[97]
The contamination was later traced to in-store tampering by a customer.[98]

Quetiapine is primarily used to treat schizophrenia or bipolar disorder.[13] Quitapine targets both positive and negative symptoms of schizophrenia.[14]

قرص quetiapine برای چیست

A 2013 Cochrane review compared quetiapine to typical antipsychotics:

Quetiapine is effective when used by itself[7] and when used along with other medications in major depressive disorder (MDD).[7][21] However, sedation is often an undesirable side effect.[7]

Quetiapine does not decrease agitation among people with Alzheimer’s. Quetiapine worsens intellectual functioning in the elderly with dementia and therefore is not recommended.[24]

The use of low doses of quetiapine for insomnia, while common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects.[25][26]

It is sometimes used off-label, often as an augmentation agent, to treat conditions such as Tourette syndrome,[27] musical hallucinations[28] and anxiety disorders.[29]

Sources for incidence lists:[2][4][22][23][31][32]

As with some other anti-psychotics, quetiapine may lower the seizure threshold,[38] and should be taken with caution in combination with drugs such as bupropion.

Quetiapine should be discontinued gradually, with careful consideration from the prescribing doctor, to avoid withdrawal symptoms or relapse.

Quetiapine has the following pharmacological actions:[50][51][52][53][54][55][56][57]

Quetiapine is a tetracyclic compound and is closely related structurally to clozapine, olanzapine, loxapine, and other tetracyclic antipsychotics.

Health Canada approved sale of Seroquel XR on September 27, 2007.[78]

قرص quetiapine برای چیست

Patent protection for the product ended in 2012; however, in a number of regions, the long-acting version remained under patent until 2017.[85]

In the United Kingdom, a month’s supply, as of 2017, costs the NHS approximately £107.45.[10] This is following an increase of 30 to 70 fold in 2017/2018.[87]

Multiple lawsuits have been filed in relation to quetiapine’s side-effects, in particular, diabetes.[88][89][90][91]

Approximately 10,000[92] lawsuits[93] have been filed against AstraZeneca, alleging that quetiapine caused problems ranging from slurred speech and chronic insomnia to deaths.

Quetiapine is primarily used to treat schizophrenia or bipolar disorder.[13] Quitapine targets both positive and negative symptoms of schizophrenia.[14]

قرص quetiapine برای چیست

A 2013 Cochrane review compared quetiapine to typical antipsychotics:

Quetiapine is effective when used by itself[7] and when used along with other medications in major depressive disorder (MDD).[7][21] However, sedation is often an undesirable side effect.[7]

Quetiapine does not decrease agitation among people with Alzheimer’s. Quetiapine worsens intellectual functioning in the elderly with dementia and therefore is not recommended.[24]

The use of low doses of quetiapine for insomnia, while common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects.[25][26]

It is sometimes used off-label, often as an augmentation agent, to treat conditions such as Tourette syndrome,[27] musical hallucinations[28] and anxiety disorders.[29]

Sources for incidence lists:[2][4][22][23][31][32]

As with some other anti-psychotics, quetiapine may lower the seizure threshold,[38] and should be taken with caution in combination with drugs such as bupropion.

Quetiapine should be discontinued gradually, with careful consideration from the prescribing doctor, to avoid withdrawal symptoms or relapse.

Quetiapine has the following pharmacological actions:[50][51][52][53][54][55][56][57]

Quetiapine is a tetracyclic compound and is closely related structurally to clozapine, olanzapine, loxapine, and other tetracyclic antipsychotics.

Health Canada approved sale of Seroquel XR on September 27, 2007.[78]

قرص quetiapine برای چیست

Patent protection for the product ended in 2012; however, in a number of regions, the long-acting version remained under patent until 2017.[85]

In the United Kingdom, a month’s supply, as of 2017, costs the NHS approximately £107.45.[10] This is following an increase of 30 to 70 fold in 2017/2018.[87]

Multiple lawsuits have been filed in relation to quetiapine’s side-effects, in particular, diabetes.[88][89][90][91]

Approximately 10,000[92] lawsuits[93] have been filed against AstraZeneca, alleging that quetiapine caused problems ranging from slurred speech and chronic insomnia to deaths.

Quetiapine is primarily used to treat schizophrenia or bipolar disorder.[13] Quitapine targets both positive and negative symptoms of schizophrenia.[14]

قرص quetiapine برای چیست

A 2013 Cochrane review compared quetiapine to typical antipsychotics:

Quetiapine is effective when used by itself[7] and when used along with other medications in major depressive disorder (MDD).[7][21] However, sedation is often an undesirable side effect.[7]

Quetiapine does not decrease agitation among people with Alzheimer’s. Quetiapine worsens intellectual functioning in the elderly with dementia and therefore is not recommended.[24]

The use of low doses of quetiapine for insomnia, while common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects.[25][26]

It is sometimes used off-label, often as an augmentation agent, to treat conditions such as Tourette syndrome,[27] musical hallucinations[28] and anxiety disorders.[29]

Sources for incidence lists:[2][4][22][23][31][32]

As with some other anti-psychotics, quetiapine may lower the seizure threshold,[38] and should be taken with caution in combination with drugs such as bupropion.

Quetiapine should be discontinued gradually, with careful consideration from the prescribing doctor, to avoid withdrawal symptoms or relapse.

Quetiapine has the following pharmacological actions:[50][51][52][53][54][55][56][57]

Quetiapine is a tetracyclic compound and is closely related structurally to clozapine, olanzapine, loxapine, and other tetracyclic antipsychotics.

Health Canada approved sale of Seroquel XR on September 27, 2007.[78]

قرص quetiapine برای چیست

Patent protection for the product ended in 2012; however, in a number of regions, the long-acting version remained under patent until 2017.[85]

In the United Kingdom, a month’s supply, as of 2017, costs the NHS approximately £107.45.[10] This is following an increase of 30 to 70 fold in 2017/2018.[87]

Multiple lawsuits have been filed in relation to quetiapine’s side-effects, in particular, diabetes.[88][89][90][91]

Approximately 10,000[92] lawsuits[93] have been filed against AstraZeneca, alleging that quetiapine caused problems ranging from slurred speech and chronic insomnia to deaths.

Quetiapine is primarily used to treat schizophrenia or bipolar disorder.[13] Quitapine targets both positive and negative symptoms of schizophrenia.[14]

قرص quetiapine برای چیست

A 2013 Cochrane review compared quetiapine to typical antipsychotics:

Quetiapine is effective when used by itself[7] and when used along with other medications in major depressive disorder (MDD).[7][21] However, sedation is often an undesirable side effect.[7]

Quetiapine does not decrease agitation among people with Alzheimer’s. Quetiapine worsens intellectual functioning in the elderly with dementia and therefore is not recommended.[24]

The use of low doses of quetiapine for insomnia, while common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects.[25][26]

It is sometimes used off-label, often as an augmentation agent, to treat conditions such as Tourette syndrome,[27] musical hallucinations[28] and anxiety disorders.[29]

Sources for incidence lists:[2][4][22][23][31][32]

As with some other anti-psychotics, quetiapine may lower the seizure threshold,[38] and should be taken with caution in combination with drugs such as bupropion.

Quetiapine should be discontinued gradually, with careful consideration from the prescribing doctor, to avoid withdrawal symptoms or relapse.

Quetiapine has the following pharmacological actions:[50][51][52][53][54][55][56][57]

Quetiapine is a tetracyclic compound and is closely related structurally to clozapine, olanzapine, loxapine, and other tetracyclic antipsychotics.

Health Canada approved sale of Seroquel XR on September 27, 2007.[78]

قرص quetiapine برای چیست

Patent protection for the product ended in 2012; however, in a number of regions, the long-acting version remained under patent until 2017.[85]

In the United Kingdom, a month’s supply, as of 2017, costs the NHS approximately £107.45.[10] This is following an increase of 30 to 70 fold in 2017/2018.[87]

Multiple lawsuits have been filed in relation to quetiapine’s side-effects, in particular, diabetes.[88][89][90][91]

Approximately 10,000[92] lawsuits[93] have been filed against AstraZeneca, alleging that quetiapine caused problems ranging from slurred speech and chronic insomnia to deaths.

کوئتیاپین (به انگلیسی: Quetiapine)، یک آنتی‌سایکوتیک آتیپیک است که برای درمان اسکیزوفرنی، اختلال دوقطبی، و همراه با یک داروی ضد افسردگی برای درمان اختلال افسردگی اساسی تأیید شده است. همچنین گاهی اوقات به عنوان کمک به خواب به علت اثر آرام بخش آن استفاده می‌شود، اما این کاربرد توصیه نمی‌شود.[۶]

Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

قرص quetiapine برای چیست

For the treatment of schizophrenia and related psychotic disorders.

Quetiapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Quetiapine is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), and dopamine type 2 (D2) receptors. Quetiapine is an antagonist at serotonin 5-HT1A and 5HT2, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors. Quetiapine has no significant affinity for cholinergic muscarinic or benzodiazepine receptors. Drowsiness and orthostatic hypotension associated with use of quetiapine may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors, respectively. Quetiapine’s antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.

Quetiapine’s antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia.

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

Rapidly and well absorbed.

83%

Hepatic. The major metabolic pathways are sulfoxidation, mediated by cytochrome P450 3A4 (CYP3A4), and oxidation of the terminal alcohol to a carboxylic acid. The major sulfoxide metabolite of quetiapine is inactive. Quetiapine also undergoes hydroxylation of the dibenzothiazepine ring, O-deakylation, N-dealkylation, and phase II conjugation. The 7-hydroxy and 7-hydroxy-
N-delakylated metabolites appear to be active, but are present in very low concentrations.

Elimination of quetiapine is mainly via hepatic metabolism. Following a single oral dose of 14C-quetiapine, less than 1% of the administered dose was excreted as unchanged drug, indicating that quetiapine is highly metabolized. Approximately 73% and 20% of the dose was recovered in the urine and feces, respectively.

6 hours

Symptoms of overdose include drowsiness and sedation, tachycardia, and hypotension.

Extended description of the mechanism of action and particular properties of each drug interaction.

A severity rating for each drug interaction, from minor to major.

A rating for the strength of the evidence supporting each drug interaction.

An effect category for each drug interaction. Know how this interaction affects the subject drug.

The date on which a patent was filed with the relevant government.

There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Contact us to learn more about these and other features.

Drug created on June 13, 2005 07:24 / Updated on July 08, 2019 12:21

Generic Name: quetiapine (kwe TYE a peen)Brand Name: SEROquel, SEROquel XR

Medically reviewed by Drugs.com on Feb 26, 2019 – Written by Cerner Multum

Quetiapine is an antipsychotic medicine that is used to treat schizophrenia in adults and children who are at least 13 years old.

Quetiapine is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Quetiapine is also used together with antidepressant medications to treat major depressive disorder in adults.

قرص quetiapine برای چیست

Quetiapine may also be used for purposes not listed in this medication guide.

Some people have thoughts about suicide while taking quetiapine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Quetiapine is not approved for use in older adults with dementia-related conditions.

You should not use quetiapine if you are allergic to it.

Quetiapine may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

Quetiapine is not approved for use by anyone younger than 10 years old.

Tell your doctor if you have ever had:

liver disease;

heart problems;

high or low blood pressure;

low white blood cell (WBC) counts;

abnormal thyroid tests or prolactin levels;

constipation or urination problems;

an enlarged prostate;

a seizure;

glaucoma or cataracts;

high cholesterol or triglycerides;

diabetes (in you or a family member); or

trouble swallowing.

Some people have thoughts about suicide while taking quetiapine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking antipsychotic medicine in the last 3 months of pregnancy may cause withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking quetiapine without your doctor’s advice.

You should not breast-feed while you are using quetiapine.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. The longer you use quetiapine, the more likely you are to develop this disorder, especially if you are an older adult. Symptoms of this disorder include tremors or other uncontrollable muscle movements.

You may take Seroquel with or without food.

You should take Seroquel XR without food or with a light meal.

Swallow the tablet whole and do not crush, chew, or break it.

Quetiapine may cause you to have high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis.

Drink plenty of liquids while you are taking quetiapine.

Blood pressure may need to be checked often in a child or teenager taking quetiapine.

You should not stop using quetiapine suddenly. Stopping suddenly may make your condition worse.

quetiapine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use quetiapine.

Store at room temperature away from moisture and heat.

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of quetiapine can be fatal.

قرص quetiapine برای چیست

Avoid drinking alcohol. Dangerous side effects could occur.

Avoid driving or hazardous activity until you know how quetiapine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid becoming overheated or dehydrated during exercise and in hot weather. You may be more prone to heat stroke.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

mask-like appearance of the face, trouble swallowing, problems with speech;

a light-headed feeling, like you might pass out;

severe constipation;

painful or difficult urination;

blurred vision, tunnel vision, eye pain, or seeing halos around lights;

severe nervous system reaction–very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting;

high blood sugar–increased thirst, increased urination, dry mouth, fruity breath odor; or

low white blood cell counts–fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed.

Common side effects may include:

speech problems;

dizziness, drowsiness, tiredness;

lack of energy;

fast heartbeats;

stuffy nose;

increased appetite, weight gain;

upset stomach, vomiting, constipation;

dry mouth; or

abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Quetiapine side effects (in more detail)

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Quetiapine can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect quetiapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Quetiapine drug interactions (in more detail)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Other brands: Seroquel, Seroquel XR

trazodone, sertraline, Xanax, Lexapro, Zoloft, fluoxetine, Cymbalta, Prozac, Abilify, Seroquel

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Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 July 2019), Cerner Multum™ (updated 1 July 2019), Wolters Kluwer™ (updated 29 June 2019) and others.

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Quetiapine is a prescription drug. It comes in the form of a tablet you take by mouth. There are two versions of the tablet. The immediate-release version is released into the bloodstream right away. The extended-release version is slowly released into your bloodstream over time.

Quetiapine is available as the brand-name drugs Seroquel (immediate-release tablet) and Seroquel XR (extended-release tablet). Both forms are also available as generic drugs. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Quetiapine may be used as part of a combination therapy. This means you may need to take it with other medications.

Quetiapine oral tablet is used to treat the symptoms of schizophrenia, bipolar disorder, or depression.

Quetiapine can be used to treat symptoms in adults who have depressive episodes or manic episodes caused by bipolar I disorder. For these cases, it can be used alone or with the drugs lithium or divalproex. It can also be used with lithium or divalproex for long-term treatment of bipolar I disorder. Quetiapine can be used in children ages 10–17 years to treat manic episodes caused by bipolar I disorder.

قرص quetiapine برای چیست

For major depression, quetiapine is used as an add-on treatment for people already taking antidepressant drugs. It’s used when your doctor decides that one antidepressant alone is not enough to treat your depression.

Quetiapine belongs to a class of drugs called atypical antipsychotics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

It isn’t known exactly how this drug works. However, it’s thought that it helps regulate the amount of certain chemicals (dopamine and serotonin) in your brain to control your condition.

Quetiapine oral tablet may cause drowsiness. It can also cause other side effects.

The side effects for this drug vary slightly based on the drug form.

The more common side effects of the immediate-release tablets can include:

The more common side effects of the extended-release tablets can include:

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Quetiapine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with quetiapine are listed below.

Do not take these drugs with quetiapine. Doing so can cause heart rhythm problems that could cause sudden death. Examples of these drugs include:

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Quetiapine can cause a severe allergic reaction. Symptoms can include:

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Quetiapine can cause drowsiness. The use of drinks that contain alcohol raises your risk of this side effect. If you drink alcohol, talk to your doctor about whether this drug is safe for you.

For people with diabetes or high blood sugar: Quetiapine may increase your blood sugar levels, which can worsen your condition. Extremely high blood sugar may lead to coma or death. If you have diabetes or risk factors of diabetes, talk with your doctor. They should check your blood sugar before and during treatment with quetiapine.

For people with hyperlipidemia (high fat levels in the blood): Quetiapine may further increase the levels of fat (cholesterol and triglycerides) in your blood. High fat levels raise your risk of heart attack and stroke. These high levels typically don’t cause symptoms. Therefore, your doctor may check your blood cholesterol and triglycerides during treatment with quetiapine.

For people with low or high blood pressure: Quetiapine may worsen your high or low blood pressure. It may also increase blood pressure in children and teenagers. Your doctor should monitor your blood pressure while you take quetiapine.

For people with a low white blood cell count: Quetiapine may lower your low white blood cell count even more. Your doctor should monitor your white blood cell count often during your first few months of treatment. This can help make sure that quetiapine is not decreasing your white blood cell count.

For people with cataracts: Quetiapine may worsen your cataracts. Your doctor will monitor you for changes in your cataracts. They will examine your eyes when you start treatment and every 6 months during treatment.

For people with seizures: Seizures have occurred in patients with or without epilepsy while taking quetiapine. Quetiapine may make it harder to control seizures in people with epilepsy. Your doctor should monitor you for an increase in seizures while taking this drug.

For people with hypothyroidism (low thyroid level): Quetiapine may lower thyroid hormone levels and worsen your existing condition. Your doctor should monitor your blood thyroid hormone levels before and during treatment with this drug.

For people with heart problems: Ask your doctor if this drug is safe for you. This drug increases the risk of abnormal heart rhythms.

For people with liver problems: Quetiapine is mainly broken down in the body by the liver. As a result, people with liver problems may have increased blood levels of this drug. This raises the risk of side effects from this drug.

For pregnant women: Quetiapine is a category C pregnancy drug. That means two things:

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk.

For women who are breastfeeding: Quetiapine may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys and livers of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

For children:

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

قرص quetiapine برای چیست

Generic: Quetiapine

Brand: Seroquel

Brand: Seroquel XR

Adult dosage (ages 18–64 years)

Immediate-release tablets

Extended-release tablets

Senior dosage (ages 65 years and older)

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body. Your doctor may start you at a dosage of 50 mg daily. They may later increase it, adding 50 mg to your daily dose. The dosage may be increased at a slower rate, and a lower total daily dose may be used to lessen the risk of side effects.

Child dosage (ages 0–17 years)

SCHIZOPHRENIA EPISODES

Child dosage (ages 13–17 years)

Immediate-release tablets

Extended-release tablets

Typical starting dosage:

Child dosage (ages 0–12 years)

It has not been confirmed that quetiapine is safe and effective to use for this purpose in children younger than 13 years.

SCHIZOPHRENIA MAINTENANCE

Child dosage (ages 0–17 years)

This medication has not been studied in children to use for this purpose. It should not be used in children younger than 18 years.

Adult dosage (ages 18–64 years)

Immediate-release tablets

Extended-release tablets

Senior dosage (ages 65 years and older)

Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body. Your doctor may start you at a dosage of 50 mg daily. They may later increase it, adding 50 mg to your daily dose. The dosage may be increased at a slower rate, and a lower total daily dose may be used to lessen the risk of side effects.

Child dosage (ages 10–17 years)

Immediate-release tablets

Extended-release tablets

Child dosage (ages 0–9 years)

It hasn’t been confirmed that quetiapine is safe and effective to use for this purpose in children younger than 10 years.

Child dosage (ages 0–17 years)

It hasn’t been confirmed that quetiapine is safe and effective to use for this purpose in children younger than 18 years.

Adult dosage (ages 18–64 years)

Immediate-release tablets

Extended-release tablets

Senior dosage (ages 65 years and older)

Child dosage (ages 0–17 years)

It hasn’t been confirmed that quetiapine is safe and effective to use for this purpose in children younger than 18 years.

Extended-release tablets

Adult dosage (ages 18–64 years)

Senior dosage (ages 65 years and older)

Child dosage (ages 0–17 years)

It hasn’t been confirmed that quetiapine is safe and effective to use for this purpose in children younger than 18 years.

If you have stopped quetiapine for more than one week, you’ll need to be restarted at a lower dosage. The dosage will then need to be increased according to the dosage schedule from when you first started the medication.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Quetiapine oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: Your condition may get worse. If you stop taking quetiapine suddenly, you may also have trouble sleeping or trouble staying asleep, or have nausea or vomiting.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: Your behavior or mood should improve.

Keep these considerations in mind if your doctor prescribes quetiapine for you.

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

When traveling with your medication:

Quetiapine can make your body less able to manage your temperature. This can cause your temperature to increase too much, leading to a condition called hyperthermia. Symptoms can include hot skin, excessive sweating, fast heartbeat, rapid breathing, and even seizures. To help prevent this, do the following during your treatment with this drug:

You and your doctor should monitor certain health issues. This can help make sure you stay safe while taking this drug. These issues include:

You may need to have blood tests from time to time to check your blood sugar and cholesterol levels. The cost of these tests will depend on your insurance coverage.

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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