قرص prednisone - کامل (هلپ کده)

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PREDNISONE- prednisone tablet Northwind Pharmaceuticals

———-

NDC:51655-410-20

MFG: 0591-5442-05

قرص prednisone

PredniSONE 10mg

20 tablets

RX only

Dosage: See package insert

Store at 68 to 77 degrees F.

Store in a tight, light-resistance container (See USP). Keep out of reach of children.

Each tablet contains Prednisone, USP 10mg

Mfg by: Watson Pharma Private Ltd Verna, Salcette Goa 403 722 India

Repackaged by Northwind Pharmaceuticals, Indianapolis, IN 46256

Lot # NW43680001

Exp Date: 04/2015

NDC:51655-410-49

MFG: 0591-5442-05

PredniSONE 10mg

42 tablets

RX only

Dosage: See package insert

Store at 68 to 77 degrees F.

Store in a tight, light-resistance container (See USP). Keep out of reach of children.

Each tablet contains Prednisone, USP 10mg

Mfg by: Watson Pharma Private Ltd Verna, Salcette Goa 403 722 India

Repackaged by Northwind Pharmaceuticals, Indianapolis, IN 46256

Lot #

Exp Date:

In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated.

Corticosteroids may mask some signs of infection, and new infections may appear during their use. Infections with any pathogen including viral, bacterial, fungal, protozoan or helminthic infections, in any location of the body, may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents that affect cellular immunity, humoral immunity, or neutrophil function.1

These infections may be mild, but can be severe and at times fatal. With increasing doses of corticosteroids, the rate of occurrence of infectious complications increases.2 There may be decreased resistance and inability to localize infection when corticosteroids are used.

Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.

USAGE IN PREGNANCY

Since adequate human reproduction studies have not been done with corticosteroids, the use of these drugs in pregnancy, nursing mothers or women of childbearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.

Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion.قرص prednisone

Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids. Killed or inactivated vaccines may be administered to patients receiving immunosuppressive doses of corticosteroids; however, the response to such vaccines may be diminished. Indicated immunization procedures may be undertaken in patients receiving nonimmunosuppressive doses of corticosteroids. The use of prednisone tablets in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimen. If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. During prolonged corticosteroid therapy, these patients should receive chemoprophylaxis.

Persons who are on drugs which suppress the immune system are more susceptible to infections than healthy individuals. Chicken pox and measles, for example, can have a more serious or even fatal course in non-immune children or adults on corticosteroids. In such children or adults who have not had these diseases, particular care should be taken to avoid exposure. How the dose, route and duration of corticosteroid administration affects the risk of developing a disseminated infection is not known. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. If exposed to chicken pox, prophylaxis with varicella zoster immune globulin (VZIG) may be indicated. If exposed to measles, prophylaxis with pooled intramuscular immunoglobulin (IG) may be indicated. (See the respective package inserts for complete VZIG and IG prescribing information.) If chicken pox develops, treatment with antiviral agents may be considered. Similarly, corticosteroids should be used with great care in patients with known or suspected Strongyloides (threadworm) infestation. In such patients, corticosteroid- induced immunosuppression may lead to Strongyloides hyperinfection and dissemination with widespread larval migration, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia.

PRECAUTIONS

General Precautions

Drug-induced, secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should be administered concurrently.

There is an enhanced effect of corticosteroids on patients with hypothyroidism and in those with cirrhosis.

Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible corneal perforation.

The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction should be gradual.

Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids.

Steroids should be used with caution in nonspecific ulcerative colitis if there is a probability of impending perforation, abscess or other pyogenic infection; diverticulitis; fresh intestinal anastomoses; active or latent peptic ulcer; renal insufficiency; hypertension; osteoporosis; and myasthenia gravis.

Growth and development of infants and children on prolonged corticosteroid therapy should be carefully observed.

Kaposi’s sarcoma has been reported to occur in patients receiving corticosteroid therapy. Discontinuation of corticosteroids may result in clinical remission.

Although controlled clinical trials have shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not show that corticosteroids affect the ultimate outcome or natural history of the disease. The studies do show that relatively high doses of corticosteroids are necessary to demonstrate a significant effect. (SeeDOSAGE AND ADMINISTRATION.)

Since complications of treatment with glucocorticoids are dependent on the size of the dose and the duration of treatment, a risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used.

Convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. Since concurrent use of these agents results in a mutual inhibition of metabolism, it is possible that adverse events associated with the individual use of either drug may be more apt to occur.

The pharmacokinetic interactions listed below are potentially clinically important. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity. Corticosteroids may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia. The effect of corticosteroids on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids.

Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.

Information for Patients

Patients who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.

Fluid and electrolyte disturbances: sodium retention; fluid retention; congestive heart failure in susceptible patients; potassium loss; hypokalemic alkalosis; hypertension.

Musculoskeletal: muscle weakness; steroid myopathy; loss of muscle mass; osteoporosis; tendon rupture, particularly of the Achilles tendon; vertebral compression fractures; aseptic necrosis of femoral and humeral heads; pathologic fracture of long bones.

Gastrointestinal: peptic ulcer with possible perforation and hemorrhage; pancreatitis; abdominal distention; ulcerative esophagitis; increases in alanine transaminase (ALT, SGPT), aspartate transaminase (AST, SGOT) and alkaline phosphatase have been observed following corticosteroid treatment. These changes are usually small, not associated with any clinical syndrome and are reversible upon discontinuation.

Dermatologic: impaired wound healing; thin fragile skin; petechiae and ecchymoses; facial erythema; increased sweating; may suppress reactions to skin tests.

Metabolic: negative nitrogen balance due to protein catabolism.

Neurological: increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatment; convulsions; vertigo; headache.

Endocrine: menstrual irregularities; development of cushingoid state; secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness; suppression of growth in children; decreased carbohydrate tolerance; manifestations of latent diabetes mellitus; increased requirements for insulin or oral hypoglycemic agents in diabetics.

Ophthalmic: posterior subcapsular cataracts; increased intraocular pressure; glaucoma; exophthalmos.

Additional Reactions: urticaria and other allergic, anaphylactic or hypersensitivity reactions.

The initial dosage of prednisone tablets may vary from 5 mg to 60 mg per day, depending on the specific disease entity being treated. In situations of less severity lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, prednisone should be discontinued and the patient transferred to other appropriate therapy. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient’s individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment; in this latter situation it may be necessary to increase the dosage of prednisone for a period of time consistent with the patient’s condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.

Multiple Sclerosis

In the treatment of acute exacerbations of multiple sclerosis daily doses of 200 mg of prednisolone for a week followed by 80 mg every other day for 1 month have been shown to be effective. (Dosage range is the same for prednisone and prednisolone.)

Alternate Day Therapy

Alternate day therapy is a corticosteroid dosing regimen in which twice the usual daily dose of corticoid is administered every other morning. The purpose of this mode of therapy is to provide the patient requiring long-term pharmacologic dose treatment with the beneficial effects of corticoids while minimizing certain undesirable effects, including pituitary-adrenal suppression, the cushingoid state, corticoid withdrawal symptoms, and growth suppression in children.

The rationale for this treatment schedule is based on two major premises: (a) the antiinflammatory or therapeutic effect of corticoids persists longer than their physical presence and metabolic effects and (b) administration of the corticosteroid every other morning allows for re-establishment of more nearly normal hypothalamic-pituitary-adrenal (HPA) activity on the off-steroid day.

A brief review of the HPA physiology may be helpful in understanding this rationale. Acting primarily through the hypothalamus a fall in free cortisol stimulates the pituitary gland to produce increasing amounts of corticotropin (ACTH) while a rise in free cortisol inhibits ACTH secretion. Normally the HPA system is characterized by diurnal (circadian) rhythm. Serum levels of ACTH rise from a low point about 10 pm to a peak level about 6 am. Increasing levels of ACTH stimulate adrenocortical activity resulting in a rise in plasma cortisol with maximal levels occurring between 2 am and 8 am. This rise in cortisol dampens ACTH production and in turn adrenocortical activity. There is a gradual fall in plasma corticoids during the day with lowest levels occurring about midnight.

The diurnal rhythm of the HPA axis is lost in Cushing’s disease, a syndrome of adrenocortical hyperfunction characterized by obesity with centripetal fat distribution, thinning of the skin with easy bruisability, muscle wasting with weakness, hypertension, latent diabetes, osteoporosis, electrolyte imbalance, etc. The same clinical findings of hyperadrenocorticism may be noted during long-term pharmacologic dose corticoid therapy administered in conventional daily divided doses. It would appear, then, that a disturbance in the diurnal cycle with maintenance of elevated corticoid values during the night may play a significant role in the development of undesirable corticoid effects. Escape from these constantly elevated plasma levels for even short periods of time may be instrumental in protecting against undesirable pharmacologic effects.

During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every 6 hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenocortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone and prednisolone, are considered to be short acting (producing adrenocortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.

The following should be kept in mind when considering alternate day therapy:

Basic principles and indications for corticosteroid therapy should apply. The benefits of alternate day therapy should not encourage the indiscriminate use of steroids.

Alternate day therapy is a therapeutic technique primarily designed for patients in whom long-term pharmacologic corticoid therapy is anticipated.

In less severe disease processes in which corticoid therapy is indicated, it may be possible to initiate treatment with alternate day therapy. More severe disease states usually will require daily divided high dose therapy for initial control of the disease process. The initial suppressive dose level should be continued until satisfactory clinical response is obtained, usually four to ten days in the case of many allergic and collagen diseases. It is important to keep the period of initial suppressive dose as brief as possible particularly when subsequent use of alternate day therapy is intended.Once control has been established, two courses are available: (a) change to alternate day therapy and then gradually reduce the amount of corticoid given every other day or (b) following control of the disease process reduce the daily dose of corticoid to the lowest effective level as rapidly as possible and then change over to an alternate-day schedule. Theoretically, course (a) may be preferable.

Because of the advantages of alternate day therapy, it may be desirable to try patients on this form of therapy who have been on daily corticoids for long periods of time (e.g., patients with rheumatoid arthritis). Since these patients may already have a suppressed HPA axis, establishing them on alternate day therapy may be difficult and not always successful. However, it is recommended that regular attempts be made to change them over. It may be helpful to triple or even quadruple the daily maintenance dose and administer this every other day rather than just doubling the daily dose if difficulty is encountered. Once the patient is again controlled, an attempt should be made to reduce this dose to a minimum.

As indicated above, certain corticosteroids, because of their prolonged suppressive effect on adrenal activity, are not recommended for alternate day therapy (e.g., dexamethasone and betamethasone).

The maximal activity of the adrenal cortex is between 2 am and 8 am, and it is minimal between 4 pm and midnight. Exogenous corticosteroids suppress adrenocortical activity the least when given at the time of maximal activity (am).

In using alternate day therapy it is important, as in all therapeutic situations, to individualize and tailor the therapy to each patient. Complete control of symptoms will not be possible in all patients. An explanation of the benefits of alternate day therapy will help the patient to understand and tolerate the possible flare-up in symptoms which may occur in the latter part of the offsteroid day. Other symptomatic therapy may be added or increased at this time if needed.

In the event of an acute flare-up of the disease process, it may be necessary to return to a full suppressive daily divided corticoid dose for control. Once control is again established alternate day therapy may be reinstituted.

Although many of the undesirable features of corticosteroid therapy can be minimized by alternate day therapy, as in any therapeutic situation, the physician must carefully weigh the benefit-risk ratio for each patient in whom corticoid therapy is being considered.

Prednisone tablets are indicated in the following conditions:

Endocrine disorders: primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance); congenital adrenal hyperplasia; hypercalcemia associated with cancer; nonsuppurative thyroiditis.

Rheumatic disorders: as adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: psoriatic arthritis, rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy), ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis, synovitis of osteoarthritis, epicondylitis.

Collagen diseases: during an exacerbation or as maintenance therapy in selected cases of: systemic lupus erythematosus, systemic dermatomyositis (polymyositis), acute rheumatic carditis.

Dermatologic diseases: pemphigus; bullous dermatitis herpetiformis; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis; mycosis fungoides; severe psoriasis; severe seborrheic dermatitis.

Allergic states: control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis; bronchial asthma; contact dermatitis; atopic dermatitis; serum sickness; drug hypersensitivity reactions.

Ophthalmic diseases: severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: allergic corneal marginal ulcers, herpes zoster ophthalmicus, anterior segment inflammation, diffuse posterior uveitis and choroiditis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, chorioretinitis, optic neuritis, iritis and iridocyclitis.

Respiratory diseases: symptomatic sarcoidosis; Loeffler’s syndrome not manageable by other means; berylliosis; fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; aspiration pneumonitis.

Hematologic disorders: idiopathic thrombocytopenic purpura in adults; secondary thrombocytopenia in adults; acquired (autoimmune) hemolytic anemia; erythroblastopenia (RBC anemia); congenital (erythroid) hypoplastic anemia.

Neoplastic diseases: for palliative management of: leukemias and lymphomas in adults, acute leukemia of childhood.

Edematous states: to induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.

Gastrointestinal diseases: to tide the patient over a critical period of the disease in: ulcerative colitis, regional enteritis.

Nervous system: acute exacerbations of multiple sclerosis.

Miscellaneous: tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy; trichinosis with neurologic or myocardial involvement.

Prednisone tablets are contraindicated in systemic fungal infections and known hypersensitivity to components.

Generic Name: prednisolone (pred NIS oh lone)Brand Name: Flo-Pred, Millipred, Millipred DP, Orapred, Orapred ODT, Pediapred, Veripred 20, …show all 26 brand namesPrelone, Hydeltra-T.B.A., Hydeltrasol, Key-Pred, Cotolone, Depo-Predate (obsolete), Predicort-50, Predalone 50, Predacort 50, Predate-50, Predaject-50, Pred-Ject-50, Key-Pred SP, Medicort, Predicort RP, Pri-Cortin 50, Predcor, Bubbli-Pred, AsmalPred Plus

Medically reviewed by Drugs.com on Sep 29, 2017 – Written by Cerner Multum

Prednisolone is a steroid that prevents the release of substances in the body that cause inflammation.

Prednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.

Prednisolone may also be used for purposes not listed in this medication guide.

قرص prednisone

You should not use prednisolone if you have a fungal infection anywhere in your body.

You should not use prednisolone if you are allergic to it, or if you have:

a fungal infection anywhere in your body.

Prednisolone can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

To make sure prednisolone is safe for you, tell your doctor if you have ever had:

active tuberculosis;

a thyroid disorder;

herpes infection of the eyes;

stomach ulcers, ulcerative colitis, or diverticulitis;

depression, mental illness, or psychosis;

liver disease (especially cirrhosis);

high blood pressure;

osteoporosis;

a muscle disorder such as myasthenia gravis; or

multiple sclerosis.

Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether prednisolone passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use prednisolone in larger or smaller amounts or for longer than recommended.

Prednisolone is sometimes taken every other day. Follow your doctor’s dosing instructions very carefully.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

You may need to shake the oral suspension (liquid) well just before you measure a dose. Follow the directions on your medicine label.

Keep the disintegrating tablet in its blister pack until you are ready to take the medicine. Open the package using dry hands, and peel back the foil from the tablet blister (do not push the tablet through the foil). Remove the tablet and place it in your mouth.

Allow the disintegrating tablet to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Your dose needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using prednisolone.

You should not stop using prednisolone suddenly. Follow your doctor’s instructions about tapering your dose.

Wear a medical alert tag or carry an ID card stating that you take prednisolone. Any medical care provider who treats you should know that you take steroid medication.

If you need surgery, tell the surgeon ahead of time that you are using prednisolone. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture and heat.

Call your doctor for instructions if you miss a dose of prednisolone.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of prednisolone is not expected to produce life threatening symptoms. However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

Do not receive a “live” vaccine while using prednisolone. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Do not receive a smallpox vaccine or you could develop serious complications.

قرص prednisone

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

shortness of breath (even with mild exertion), swelling, rapid weight gain;

bruising, thinning skin, or any wound that will not heal;

severe depression, changes in personality, unusual thoughts or behavior;

new or unusual pain in an arm or leg or in your back;

bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

severe pain in your upper stomach spreading to your back, nausea and vomiting;

a seizure (convulsions); or

low potassium–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling.

Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using prednisolone.

Common side effects may include:

fluid retention (swelling in your hands or ankles);

dizziness, spinning sensation;

changes in your menstrual periods;

headache;

muscle pain or weakness; or

stomach discomfort, bloating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Prednisolone side effects (in more detail)

Other drugs may interact with prednisolone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Prednisolone drug interactions (in more detail)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 7.01.

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A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

A governmentally-recognized ID which uniquely identifies the product within its regulatory market.قرص prednisone

For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison’s disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn’s disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin’s or non-Hodgkin’s lynphomas, Waldenstrom’s macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optoc neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler’s syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis.

Prednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has some mineralocorticoid activity and thus may affect ion exchange in the kidney.

Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisone can stimulate secretion of various components of gastric juice. Suppression of the production of corticotropin may lead to suppression of endogenous corticosteroids. Prednisone has slight mineralocorticoid activity, whereby entry of sodium into cells and loss of intracellular potassium is stimulated. This is particularly evident in the kidney, where rapid ion exchange leads to sodium retention and hypertension.

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

Readily absorbed from the gastrointestinal tract. Rayos, the delayed-release formulation, has a 4-hour release time. To compare, the delayed-release formulation has a Tmax of 6.0 – 6.5 hours in healthy male subjects, whereas the immediate-release formulation has a Tmax of 2.0 hours. The rate of absorption, Cmax, and exposure is comparable between formulations.

Extensively bound to plasma proteins.

Prednisone is completely converted to the active metabolite prednisolone by 11β-hydroxysteroid dehydrogenases. It is then further metabolized mainly in the liver. The exposure of prednisolone is 4-6 fold higher than that of prednisone.

Excreted in the urine as sulfate and glucuronide conjugates.

Half life of both the immediate- and delayed- release formulation is 2 to 3 hours.

Extended description of the mechanism of action and particular properties of each drug interaction.

A severity rating for each drug interaction, from minor to major.

A rating for the strength of the evidence supporting each drug interaction.

An effect category for each drug interaction. Know how this interaction affects the subject drug.

Jean Buendia, Michel Vivat, “Process for the production of prednisone 17.21-diacylates.” U.S. Patent US4601854, issued May, 1982.

The date on which a patent was filed with the relevant government.

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Drug created on June 13, 2005 07:24 / Updated on July 15, 2019 21:27

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قرص prednisone

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Drug formulary

Find out about drugs approved by the Kaiser Permanente Pharmacy and Therapeutics Committee for use in your care.

Covered drugs

Kaiser Permanente health plans around the country: Kaiser Foundation Health Plan, Inc., in Northern and Southern California and Hawaii • Kaiser Foundation Health Plan of Colorado • Kaiser Foundation Health Plan of Georgia, Inc., Nine Piedmont Center, 3495 Piedmont Road NE, Atlanta, GA 30305, 404-364-7000 • Kaiser Foundation Health Plan of the Mid-Atlantic States, Inc., in Maryland, Virginia, and Washington, D.C., 2101 E. Jefferson St., Rockville, MD 20852 • Kaiser Foundation Health Plan of the Northwest, 500 NE Multnomah St., Suite 100, Portland, OR 97232 • Kaiser Foundation Health Plan of Washington or Kaiser Foundation Health Plan of Washington Options, Inc., 601 Union St., Suite 3100, Seattle, WA 98101

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© 2019 Kaiser Foundation Health Plan, Inc.

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Generic name:Prednisone – oral

Pronunciation(PRED-ni-sone)

Brand name(s)Deltasone

Prednisone is used to treat conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders. Prednisone belongs to a class of drugs known as corticosteroids. It decreases your immune system’s response to various diseases to reduce symptoms such as swelling and allergic-type reactions.قرص prednisone

Take this medication by mouth, with food or milk to prevent stomach upset, as directed by your doctor. Take the tablet form of this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If you are prescribed only one dose per day, take it in the morning before 9 A.M.

Take this medication exactly as directed by your doctor. Follow the dosing schedule carefully. The dosage and length of treatment are based on your medical condition and response to treatment. If you are taking this medication on a different schedule than a daily one (such as every other day), it may help to mark your calendar with a reminder.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away.

Tell your doctor if your condition persists or worsens.

Nausea, vomiting, loss of appetite, heartburn, trouble sleeping, increased sweating, or acne may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur:

This medication may rarely make your blood sugar rise, which can cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Before taking prednisone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may mask signs of infection. It can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

The liquid form of this medication may contain sugar and/or alcohol. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

This medication may cause vaccines not to work as well. Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages. Consult your doctor or pharmacist for more information.

This medication may slow down a child’s growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child’s height and growth can be checked.

During pregnancy, this medication should be used only when clearly needed. It may rarely harm an unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems. Tell your doctor right away if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn.

This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include:

If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (including skin tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

If this medication is used for an extended time, laboratory and/or medical tests (such as blood mineral levels, blood glucose, complete blood count, height/weight measurements, bone density tests, blood pressure, eye exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

This medication may cause bone problems (osteoporosis) when taken for an extended time. Lifestyle changes that may help reduce the risk of bone problems include doing weight-bearing exercise, getting enough calcium and vitamin D, stopping smoking, and limiting alcohol. Discuss with your doctor lifestyle changes that might benefit you.

If you are taking this medication daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

If you are taking this medication on a different schedule than a daily one (such as every other day), ask your doctor ahead of time about what you should do if you miss a dose.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.قرص prednisone

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Information last revised July 2018.

Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider.

The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment.

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مدپلاس

پردنیزون (Prednisone) یک استروئید از نوع کورتیکواستروئید می باشد٬ پردنیزون از انتشار موادی که باعث التهاب در بدن می شود جلوگیری می کند.

پردنیزون به عنوان یک ضد التهاب و یا داروی سرکوب کننده ایمنی استفاده می شود.
پردنیزون در بسیاری از شرایط مختلف از قبیل اختلالات آلرژیک، بیماری های پوستی، کولیت اولسراتیو، ورم مفاصل، لوپوس، پسوریازیس، و یا درمان اختلالات تنفسی مورد استفاده قرار می گیرد.

درمان آلرژی شدید، ورم مفاصل، آسم، ام اس و بیماری های پوستی.
این دارو ممکن است برای شرایط دیگر که توسط دکتر شما تعیین می شود مورد استفاده قرار گیرد.

نام ژنریک: پردنیزون (Prednisone)

قرص prednisone

نام تجاری: Rayos, Sterapred, Sterapred 12 DAY, Sterapred DS, Sterapred DS 12 DAY, Deltasone, Meticorten, Liquid Pred, Orasone, Prednicen-M, Prednicot

کلاس درمانی: غدد درونریز و متابولیسم، متابولیک عامل

کلاس دارویی: آدرنال گلوکوکورتیکوئید

کاربرد در MS: تشدید موارد حاد

داروهای استروئیدی می تواند سیستم ایمنی بدن شما را تضعیف، و راه را برای ایجاد عفونت آسان تر کند.
استروئیدها همچنین می توانید عفونت موجود در بدن را وخیم تر سازند، و یا فعال سازند.
قبل از مصرف این دارو، از دکتر خود در مورد هر گونه بیماری یا عفونت در چند هفته گذشته بگویید.

برای اینکه مطمئن شوید این دارو برای شما بی خطر است٬ در مورد تمامی سابقه ها و حساسیت های خاص٬ پزشک خود را در جریان قرار دهید .

هر بیماری که باعث اسهال می شود؛
بیماری های کبدی (مانند سیروز)؛
بیماری کلیوی.
بیماری های قلبی، فشار خون بالا، سطوح پایین پتاسیم در خون شما.
بیماری های تیروئید.
دیابت.
سابقه مالاریا.
سل.
پوکی استخوان؛
آب سیاه، آب مروارید، یا عفونت هرپس چشم.
زخم معده، کولیت اولسراتیو و یا سابقه خونریزی معده.
یک اختلال عضلانی مانند میاستنی گراویس؛
افسردگی یا بیماری های روانی.

استروئیدها می تواند به رشد در کودکان تاثیر می گذارد٬ اگر کودک شما از این دارو استفاده میکند و شما فکر میکنید به اندازه کافی رشد نکرده است با پزشک او صحبت نمایید.

استفاده طولانی مدت از استروئیدها ممکن است باعث از دست رفتن استخوان (پوکی استخوان) شود، به ویژه اگر شما سیگار می کشید، اگر شما ورزش نمی کنید، اگر شما به اندازه کافی ویتامین D و کلسیم در رژیم غذایی خود مصرف نمی کنید، و یا اگر شما یک سابقه خانوادگی از پوکی استخوان داشته باشید؛ با پزشک خود در مورد خطرات ابتلا به پوکی استخوان در مصرف این دارو مشورت کنید .

مصرف پردنیزون در طول سه ماهه اول بارداری می توانید باعث کاهش وزن هنگام تولد یا ناهنجاری در جنین شود؛ اگر شما باردار می باشید ٬ قبل از مصرف این دارو با پزشک خود صحبت نمایید .

پردنیزون میتواند به شیر مادر منتقل شود و به کودک شیرخوار آسیب برساند ٬ در هر صورت قبل از مصرف این دارو در دوران شیردهی با پزشک خود مشورت نمایید.

اگر شما پس از مصرف این دارو دچار هر یک از عارضه های زیر شدید٬ سریعا با پزشک خود تماس گرفته و او را در جریان قرار دهید .

تاری دید، درد چشم، یا دیدن هاله در اطراف چراغ.
تورم، افزایش وزن سریع، کوتاهی تنفس.
افسردگی شدید، احساس شادی افراطی و یا غم و اندوه، تغییر در شخصیت و یا رفتار، تشنج ؛
مدفوع خونی یا قیری شکل، سرفه خونی؛
پانکراتیت (درد شدید در قسمت فوقانی معده و گسترش به پشت، تهوع و استفراغ، ضربان قلب سریع )؛
پتاسیم کم (گیجی، نرخ ناهموار قلب، تشنگی شدید، افزایش ادرار، درد پا، ضعف عضلات و یا احساس لنگی)؛
فشار خون بالا و خطرناک (سردرد شدید، تاری دید، وزوز در گوش خود، اضطراب، گیجی، درد قفسه سینه، تنگی نفس، ضربان قلب ناهموار، تشنج).

مشکلات خواب (بی خوابی)، تغییرات خلق و خو.
افزایش اشتها، افزایش وزن تدریجی.
آکنه، افزایش تعریق، پوست خشک، پوست نازک، کبودی و یا تغییر رنگ.
سرعت بهبود زخم.
سردرد، سرگیجه، احساس چرخش.
تهوع، درد معده، نفخ.
تغییر در شکل و یا مکان از چربی بدن (به خصوص در دست ها، پاها، صورت، گردن، سینه و کمر).

قبل از استفاده از این دارو با دکتر خود در مورد تمام نسخه ها و داروهایی که استفاده می کنید ( حتی ویتامین ها، مواد معدنی، داروهای گیاهی و … ) مشورت نمایید٬ به خصوص داروهای زیر :

آمفوتریسین B؛
سیکلوسپورین.
دیگوکسین، دیجیتال.
مخمر سنت جان.
یک آنتی بیوتیک مانند کلاریترومایسین یا telithromycin.
داروهای ضد قارچ مانند ایتراکونازول، کتوکونازول، posaconazole وریکونازول.
قرص های ضد بارداری و هورمونی .
رقیق کننده خون مانند وارفارین، کومادین؛
ادرار آور و یا “قرص آب”؛
boceprevir یا telaprevir داروهای هپاتیت C؛
داروهای HIV و AIDS مانند atazanavir، delavirdine، efavirenz، fosamprenavir، indinavir، nelfinavir، nevirapine، ریتوناویر، ساکوییناویر.
داروهای انسولین یا دیابت خوراکی از طریق دهان.
یک داروی ضد التهابی غیر استروئیدی (NSAID) مانند آسپیرین، ایبوپروفن (Advil، و موترین)، ناپروکسن، سلکوکسیب، دیکلوفناک، ایندومتاسین، meloxicam، و غیره.
داروهای تشنج مانند کاربامازپین، fosphenytoin، oxcarbazepine، فنوباربیتال، فنی توئین، پریمیدون هستند.
داروهای سل ایزونیازید، rifabutin، rifapentine، و یا ریفامپین.

مطلب قبلی

دگزامتازون Dexamethasone

مطلب بعدی

تولترودین Tolterodine (دترول)

سوماتروپین

آلپرازولام Alprazolam

آمپی سیلین

جنتامایسین

کلرامفنيکل | Chloramphenicol

تهیه روغن گل سرخ در خانه

ایمیل شما نمایش داده نخواهد شد

مشخصات من را ذخیره کن

کد کپچا *

قرص prednisone

دریافت مطالب جدید , اخبار و اطلاعیه ها در ایمیل شما

از عضویت شما سپاسگذاریم . ایمیل خود را جهت تایید بررسی کنید

مطالب تصادفی

درمان تنبلی کبد با کاسنی

آموزش ترغیب شیرخواران و کودکان نوپا به غذا خوردن

کتاب وضعیت آخر | به سوی سلامت روان

قارچ گیاهی برای مبارزه با سرطان ها

نکات ساده غذایی برای کاهش وزن زیاد

گیاهخواران عمری طولانی تر دارند

حجامت نقش مهمی در پیشگیری از بیماری‌ها دارد

5 اشتباه بزرگ در مورد رژیم غذایی و آرتروز

آیا اندازه آلت تناسلی من نرمال است ؟

گیاهان تهدید کننده سلامت کودک

کاهش وزن با رعایت این نکات کاربردی

عادت های مخرب کلیه

با فواید عصاره سیر و لیمو ترش آشنا شوید –…

برقرای یک رابطه جنسی خوب با همسر

خودمراقبتی در بهداشت چشم

کاهش هوس خوردن شکر با مصرف این ۷ خوراکی

رژیم سبزیجات برای دیابت نوع دو مفید است

اطلاعاتی درباره ی باید و نبایدهای خواب نوزادان

مصرف روزانه میوه‌ و سبزیجات در کودکان

زمانی که سیســتم ایمنی پیام هــای غلطی را به پوســت می فرســتد و باعث رشــد بیشتر ســلول های آن می شــود؛ چندین لایه ســلول مرده به شکل پوســته های ســفید رنگ در سطح پوست تجمع پیدا می کنند.

(بیشتر بخوانید : پسوریازیس )

Prednisone is a medication designed to prevent the release of substances in the body that can cause inflammation, thereby lowering redness and swelling. It can treat low corticosteroid levels, or other conditions in patients with normal corticosteroid levels, such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.

Prednisone can also be used to treat the symptoms of certain types of cancer. It is sometimes used with antibiotics to treat a certain type of pneumonia in patients with HIV/AIDS.

Prednisone is available as a tablet, a liquid, and a concentrated solution, designed to be taken orally. Dosing and schedule depends entirely on the patient and the condition being treated. The NIH recommends discussing any grapefruit and grapefruit juice intake with your doctor, as it can affect the absorption of the medication.

Because prednisone can cause unusual results in some medical tests, it’s important to tell any doctor who treats you that you are using prednisone. The NIH recommends wearing a medical alert tag or carrying an ID card stating that you take prednisone in case you end up in an emergency room and are unable to communicate.

The NIH recommends taking prednisone with food and to strictly follow the doctor’s dosing instructions. If taking the drug as a liquid, measure it with the special dose-measuring spoon or medicine cup, which a pharmacist can provide. Delayed-release tablets should be kept whole as a dosage, and it’s not recommended that patients crush, chew, or break the tablet. Changing the dosage without consulting a physician can cause side effects, including withdrawal and overdose.قرص prednisone

Because of the nature of prednisone, it can cause complications when taken at the same time as other medications. According to the NIH, these drugs include: antibiotics, antifungal medications, birth control pills and other hormones, blood thinners, diuretics, HIV or AIDS medication, insulin, NSAIDs and seizure medications. If you are taking any of these medications, the NIH recommends telling your doctor before taking prednisone.

The NIH also recommends telling your doctor if you are taking any herbal nutritional supplements, especially St. John’s wort.

Prednisone is also designed to weaken the immune system, so a patient using the drug is at a higher risk of infection or being sick. It is important for those on prednisone to avoid being near ill people.

According to the National Institutes of Health, patients considering or taking prednisone should take special precautions:

Long-term use of any steroid, including prednisone, can cause bone loss or osteoporosis. The risk is higher in smokers, those who do not exercise, and those with vitamin D/calcium deficiencies. These are important factors to weigh with your doctor. Your doctor may recommend a low-salt, high potassium, and/or high calcium diet.

For pregnant women, prednisone can cause low weight birth or other birth defects if taken in the first trimester. Prednisone can also be passed onto a nursing baby through breast milk. According to the NIH, discuss proper birth control methods and let your doctor know if you plan to get pregnant or are pregnant while taking this medication.

The use of prednisone is carefully monitored in children, as the corticosteroid can cause problems with growth. It is recommended that you alert your child’s doctor if you think that your child’s growth has been affected while using prednisone.

Like other steroids, prednisone has a number of unpleasant side effects. Commonly, patients will experience:

Changes in the shape and location of body fat, particularly in the arms, legs, face, neck, breasts, and waist

Side effects can be amplified if prednisone is consumed in conjunction with alcohol, so safetymedical.com recommends avoiding alcohol.

Alcohol can also exacerbate the mental effects of prednisone, as it is a depressant. It can also increase irritation to the gastrointestinal system, as well as lowering the immune system. Combining alcohol and prednisone can worsen the possibility of any of the listed side effects.

Prednisone is not an addictive substance. However, when going off of the medication, it’s important to work with your doctor to avoid withdrawal symptoms. Withdrawal symptoms of prednisone include weakness, fatigue, weight loss, nausea, low blood pressure, and menstrual changes.

Prednisone overdoses are generally not life-threatening. However, like with any drug, if you suspect an overdose, call poison control or emergency medical services.

Long-term high doses of steroids can cause thinning skin, easy bruising, body shape changes, increased body hair and acne, menstrual problems, impotence, and sexual performance issues. Though none of these problems are life-threatening, steroid abuse can still lead to other health complications.

Prednisone is also designed for similar use in pets. It is used by veterinarians to reduce inflammation and suppress the immune system. According to PetMD, the drug should not be administered to pregnant pets or pets with diabetes. Prolonged use can lead to diabetes or Cushing’s disease.