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فکسوفنادین (به انگلیسی: Fexofenadine)
رده درمانی: آنتی هیستامین
اشکال دارویی: قرص
فکسوفنادین برای جلوگیری ازعلایم ناشی از حساسیت، مانند تب یونجه، کهیر و حساسیت‌های فصلی به کار برده می‌شود.
قرص fexofenadine
اثر ضد آلرژی این دارو ناشی از رقابت آن با هیستامین برای‌اتصال به گیرنده‌های H۱ است و به این‌ترتیب از بروز اثرات هیستامین جلوگیری می‌کند.
حدود یک سوم فکسوفنادین از دستگاه گوارش جذب می‌گردد. برخی از آن به پروتئینهای پلاسما متصل می‌شود و به‌صورت متابولیت در ادرار و مدفوع دفع می‌گردد.
مهمترین عارضه جانبی این‌دارو احتمال بروز آریتمی قلبی و افزایش فاصله QT است.
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Fexofenadine is an antihistamine medicine that helps with the symptoms of allergies.
It’s used to treat:
Fexofenadine is known as a non-drowsy antihistamine. It’s less likely to make you feel sleepy than some other antihistamines.قرص fexofenadine
Fexofenadine is available on prescription. It comes as tablets.
Fexofenadine tablets can be taken by adults under the age of 65 and children aged 6 years and over.
Fexofenadine isn’t recommended for people over 65 years old because there isn’t much research on the medicine in this age group.
Talk to your pharmacist or doctor if you’re over 65 and want to take fexofenadine.
Fexofenadine isn’t suitable for some people. Tell your doctor or pharmacist if you:
If you or your child have been prescribed fexofenadine, follow your doctor’s instructions about how and when to take it.
Fexofenadine comes as tablets (30mg, 120mg and 180mg).
How much you take depends on why you’re taking it:
If you’re taking 30mg fexofenadine tablets, you can take them with or without food.
If you’re taking 120mg and 180mg fexofenadine tablets, take them before a meal.
Always take your fexofenadine tablets with a drink of water. Swallow them whole – do not chew them.
You may only need to take fexofenadine on a day you have symptoms, such as if you have been exposed to something you’re allergic to, like animal hair.
Or you may need to take it regularly to prevent symptoms, such as to stop hay fever during spring and summer.
If you’re taking fexofenadine once a day, do not take a double dose to make up for a forgotten dose. Take the next dose at the usual time as prescribed by your doctor.
If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
Fexofenadine is generally very safe. Taking too much is unlikely to harm you.
If you take an extra dose by mistake, you might get some of the common side effects. If this happens or you’re concerned, contact your doctor.
Like all medicines, fexofenadine can cause side effects, although not everyone gets them.
Common side effects of fexofenadine happen in more than 1 in 100 people.
Talk to your doctor or pharmacist if these side effects bother you or don’t go away:
It’s rare to have a serious side effect with fexofenadine. Call a doctor straight away if you get a fast or irregular heartbeat.
In rare cases, fexofenadine may cause a serious allergic reaction (anaphylaxis).
These are warning signs of a serious allergic reaction. A serious allergic reaction is an emergency.
These are not all the side effects of fexofenadine. For a full list, see the leaflet inside your medicine packet.
You can report any suspected side effect to the UK safety scheme.
What to do about:
Fexofenadine isn’t normally recommended during pregnancy.
A similar antihistamine called loratadine is normally used first because there’s more information to say that it’s safe.
Talk to your doctor about the benefits and possible harms of taking fexofenadine. It’ll also depend on how many weeks pregnant you are and the reason you need to take fexofenadine.
For more information about how fexofenadine can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.
There’s not a lot of information on the use of fexofenadine during breastfeeding, so it’s best not to take it.
It’s usually safe to take similar antihistamines called loratadine and cetirizine while you’re breastfeeding.
But speak to your doctor before taking any antihistamine if your baby was premature, had a low birth weight, or has other health problems.
Some medicines and fexofenadine interfere with each other and increase the chances of you having side effects.
Check with your pharmacist or doctor if you’re taking:
قرص fexofenadine
There might be a problem taking some herbal remedies and supplements alongside fexofenadine, especially ones that cause sleepiness, a dry mouth, or make it difficult to pee.
Ask your pharmacist for advice.
Tell your doctor or pharmacist if you’re taking any other medicines, including herbal remedies, vitamins or supplements.
Fexofenadine is a medicine called an antihistamine.
When you come into contact with something you’re allergic to, such as pollen, animal hair or fur, house dust, or insect bites and stings, your body produces a chemical called histamine.
Usually histamine is a useful substance, but in an allergic reaction it causes unpleasant symptoms including itchy, watery eyes, a running or blocked nose, sneezing and skin rashes.
Fexofenadine blocks the effects of histamine and reduces these symptoms.
You should start to feel better within an hour or two.
It depends on why you’re taking fexofenadine.
You may only need to take it as a one-off dose or for a day or two – for example, if you have a reaction to an insect bite.
You may need to take fexofenadine for longer if you’re taking it to prevent symptoms – for example, to stop hay fever when the pollen count is high.
Talk to your doctor or pharmacist if you’re unsure how long you need to take fexofenadine for.
Fexofenadine is unlikely to do you any harm if you take it for a long time. But it’s best to take fexofenadine only for as long as you need to.
It’s best not to drink alcohol while you’re taking fexofenadine as it can make you feel sleepy.
Do not drink grapefruit juice, orange juice or apple juice while taking fexofenadine. It might make you more likely to have side effects.
Fexofenadine is classed as a non-drowsy antihistamine, but it’s still possible to feel sleepy after taking it.
If you’re taking fexofenadine for the first time, see how it makes you feel before driving, cycling, or using heavy machinery or tools.
Fexofenadine isn’t known to cause weight gain.
Fexofenadine is known as a non-drowsy antihistamine. That’s because it’s less likely to make you feel sleepy than so-called sedating antihistamines, such as Piriton (chlorphenamine).
Most people prefer to take a non-drowsy antihistamine instead of a sedating one.
An exception is when you want the medicine to make you sleepy – for example, if you have itchy skin that’s keeping you awake.
Other non-drowsy antihistamines like acrivastine, cetirizine, loratadine, desloratadine and levocetirizine seem to work just as well as fexofenadine.
But fexofenadine seems to be less likely to make you feel sleepy than other non-drowsy antihistamines.
If one non-drowsy antihistamine hasn’t worked for you, it’s worth trying another one.
For a medicine to become available to buy without a prescription, it has to be shown to be safe enough to use without the need to see a doctor.
Unlike some other antihistamines, fexofenadine hasn’t been through this process yet.
Yes, you can take fexofenadine together with paracetamol or ibuprofen.
Sometimes doctors recommend that people with a severe itchy skin rash take 2 different antihistamines together for a few days.
As well as taking a non-drowsy antihistamine during the day (such as fexofenadine, cetirizine or loratadine), your doctor may suggest that you take a sedating antihistamine at night time if the itch is making it difficult to sleep.
Do not take 2 antihistamines together unless your doctor advises you to.
Yes, it’s fine to take fexofenadine together with other hay fever treatments – for example, steroid nasal sprays (such as Beconase, Rhinacort Aqua and Flixonase Nasules) or eye drops.
Your doctor might suggest you or your child take a higher dose of fexofenadine (up to 4 times the usual dose) for a severe itchy skin rash or swelling underneath the skin (angioedema).
Taking high doses of fexofenadine isn’t suitable for everyone. Speak to your doctor if you don’t think fexofenadine is working for you.
There’s no firm evidence to suggest that taking fexofenadine will reduce fertility in either men or women.
But speak to a pharmacist or your doctor before taking it if you’re trying to get pregnant.
Fexofenadine doesn’t affect any type of contraception, including the combined pill and emergency contraception.
It’ll help if you don’t spend too much time outside if the pollen count is high.
Page last reviewed: 19 October 2018
Next review due: 19 October 2021
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Generic Name: fexofenadine (FEX oh FEN a deen)Brand Name: Allegra, Aller-Ease, Children’s Allegra Allergy, Mucinex Allergy, Wal-Fex, …show all 11 brand namesAllegra ODT, Allegra 24 Hour Allergy, Allegra Allergy, Children’s Allegra ODT, Allergy Relief (Fexofenadine HCl), Allegra OTC
Medically reviewed by Drugs.com on May 1, 2019 – Written by Cerner Multum
Fexofenadine is an antihistamine that is used to treat the symptoms of seasonal allergies (hay fever) in adults and children.
Fexofenadine is also used to treat skin itching and hives caused by a condition called chronic idiopathic urticaria in adults and children at least 6 years old.
There are many brands and forms of fexofenadine available. Not all brands are listed on this leaflet.قرص fexofenadine
Fexofenadine may also be used for purposes not listed in this medication guide.
Do not take fexofenadine with fruit juice (such as apple, orange, or grapefruit).
You should not use fexofenadine if you are allergic to it.
Ask a doctor or pharmacist if fexofenadine is safe to use if you have:
kidney disease.
Ask a doctor before using this medicine if you are pregnant or breastfeeding.
Older adults may be more sensitive to the effects of this medicine. If you are 65 or older, ask a doctor before taking fexofenadine.
This medicine may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Use exactly as directed on the label, or as prescribed by your doctor.
Always follow directions on the medicine label about giving cough or cold medicine to a child.
Ask a doctor before giving fexofenadine liquid to a child younger than 2 years old.
The disintegrating (melting) tablets are not for use in a child younger than 6 years old.
The 12-hour and 24-hour forms of fexofenadine are not for use in a child younger than 12 years old.
Take this medicine only with water.
Take the disintegrating tablet on an empty stomach.
Shake the oral suspension (liquid) before you measure a dose. Use the dosing cup provided, or use a medicine dose-measuring device (not a kitchen spoon).
Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet on your tongue and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves.
Call your doctor if your symptoms do not improve, or if they get worse.
Store fexofenadine in its original package at room temperature, away from moisture and heat. Do not allow liquid medicine to freeze.
Since allergy medicine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it’s almost time for your next dose. Do not use two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include dry mouth, dizziness, or drowsiness.
Do not take fexofenadine with fruit juice (such as apple, orange, or grapefruit). These juices can make it harder for your body to absorb fexofenadine.
Avoid taking an antacid within 2 hours before or after you take fexofenadine. Certain antacids can make it harder for your body to absorb fexofenadine.
Ask a doctor or pharmacist before using other cough or cold medicines that may contain similar ingredients.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using fexofenadine and call your doctor at once if you have:
flu-like symptoms (fever, chills, unusual tiredness);
new or worsening cough;
pain; or
signs of an ear infection–fever, ear pain or full feeling, trouble hearing, drainage from the ear, fussiness in a child.
Common side effects may include:
headache;
back pain; or
cold symptoms such as stuffy nose, sinus pain, sore throat.
قرص fexofenadine
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Fexofenadine side effects (in more detail)
Using fexofenadine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Ask a doctor or pharmacist before using fexofenadine with any other medications, especially:
ketoconazole; or
erythromycin.
This list is not complete. Other drugs may affect fexofenadine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Fexofenadine drug interactions (in more detail)
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 11.01.
Medical Disclaimer
Other brands: Allegra, Allegra Allergy, Allegra ODT, Aller-Ease, Mucinex Allergy
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Fexofenadine reviews
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Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.قرص fexofenadine
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
For management of Seasonal allergic rhinitis
Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be “activated,” releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential of terfenadine, since it does not block the potassium channel involved in repolarization of cardiac cells.
Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Conversely, fexofenadine does not demonstrate any anticholinergic, antidopaminergic, alpha-1 adrenergic, or beta-adrenergic-receptor blocking activity.
Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.
Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.
Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.
33%
60%-70%
Approximately 5% of the total dose is metabolized, by cytochrome P450 3A4 and by intestinal microflora.
14.4 hours
Side effects include dizziness, drowsiness, and dry mouth.
Extended description of the mechanism of action and particular properties of each drug interaction.
A severity rating for each drug interaction, from minor to major.
A rating for the strength of the evidence supporting each drug interaction.
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Federico Milla, “Processes for the production of fexofenadine.” U.S. Patent US20030166682, issued September 04, 2003.
The date on which a patent was filed with the relevant government.
There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Contact us to learn more about these and other features.
Drug created on June 13, 2005 07:24 / Updated on July 29, 2019 13:20
Mansfield LE(1).
Author information:
(1)Texas Tech Regional Health Science Center, 1901 Arizona Avenue, El Paso, Texas 79902, USA. immunman@pol.net
Allergic rhinitis is a common chronic condition in children. Oral antihistamines
are a first-line treatment option in allergic rhinitis and different formulations
are available to aid administration to children. The tablet formulation of the
second-generation antihistamine fexofenadine has established efficacy and safety
in both adults and children. To aid administration in young children, a new oral
suspension formulation of fexofenadine has been developed, indicated for the
relief of seasonal allergic rhinitis symptoms in children aged 2-11 years and for
uncomplicated skin manifestations of chronic idiopathic urticaria in children
aged 6 months-11 years. Clinical studies have shown the oral suspension to have
both bioequivalence with the 30 mg tablet formulation and a favorable safety and
tolerability profile.
قرص fexofenadine
Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Search for terms
Allergic Rhinitis (AR) is a global health problem. It is the cause of major illness and disability worldwide. Estimates indicate that 10-25% of population worldwide is affected by AR. The main symptoms of AR include nasal congestion, rhinorrhea, itching, sneezing and non-nasal symptoms like burning, itching and watery eyes or itching ears and palate. These symptoms can have a considerable toll on patient’s quality of life by interfering with cognitive and emotional functioning. The estimated annual cost attributable to AR in United States ranges from $1.4 billion to nearly $ 6 billion in direct cost annually. Today’s antiallergic therapy is based on avoidance of the causative allergen, symptomatic pharmacotherapy, specific immunotherapy and education. Oral/intranasal H1-antihistaminics, decongestants, leukotrienes receptor antagonists, intranasal corticosteroids are the pillars in the management of allergic rhinitis. Second generation antihistamines have become increasingly popular because of their comparable efficacy and lower incidence of adverse effects relative to first generation counterparts. Levocetirizine, a potent second generation histamine (H1) receptor antagonist, is effective against persistent allergic rhinitis and thus improves quality of life and reduces co-morbidities and societal costs. Fexofenadine, is a selective, non sedating, second generation H1 receptor antagonist which have an additional impact on the inflammatory mediators. Monteleukast is a highly selective type I receptor antagonist of leukotriene D4. The leukotrienes modifiers have both anti-inflammatory and bronchodilator properties.
The literature search establishes that addition of an antihistamine to montelukast has added benefit. The combination therapy of montelukast with antihistamine provide enhancing and complimentary effects thereby reducing the symptoms effectively. The results with concomitant levocetirizine and montelukast treatment are better as compared to monotherapy with levocetirizine on symptoms and quality of life in allergic rhinitis. Fexofenadine along with montelukast is more effective than antihistaminic alone in control of allergic rhinitis symptoms. There is literature available for the comparisons of concomitant levocetirizine and montelukast with monotherapy or placebo and comparisons of concomitant fexofenadine and montelukast with monotherapy or placebo. But scanty data is available regarding comparisons of concomitant montelukast-levocetirizine with montelukast-fexofenadine.
قرص fexofenadine
direct cost parameters were taken into consideration. Direct cost parameters were cost of medications used, medical procedures and hospitalization charges, if any. Cost-effectiveness ratio of both treatment groups were calculated based on formula as given below.
Cost-effectiveness ratio = cost / outcome Outcome was measured in terms of effectiveness. TNSS parameter was the main effectiveness parameter.
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Exclusion Criteria:
