خواص دارویی و گیاهی

weißes bis fast weißes, polymorphes, kristallines Pulver[1]

R06AX13

Systemische Antihistaminika

Antagonist an Histamin-H1-Rezeptoren

fest

drug loratadine 10 mg

134–136 °C[2]

> 5 g·kg−1 (LD50, Ratte, oral)[3]

Loratadin ist ein Arzneistoff aus der Gruppe der Antihistaminika, der zur Linderung der Beschwerden bei Allergien und beim atopischen Ekzem (Neurodermitis) eingesetzt wird. Es wurde 1989 in Deutschland eingeführt und ist seit 1994 nicht mehr verschreibungspflichtig. In Österreich ist es in Dosierungen bis 10 mg pro Tag für Jugendliche über 12 Jahren und Erwachsene ohne Rezept erhältlich.[4] In Deutschland sind Fertigarzneimittel mit Loratadin als Tablette oder Brausetablette erhältlich, in den USA und Großbritannien gibt es zusätzlich Saft. Seit 2013 steht es auf der Liste der unentbehrlichen Arzneimittel der WHO.

Loratadin ist ein H1-Antihistaminikum der 2. Generation. Es blockiert die speziellen Bindungsstellen für Histamin an den Histamin-H1-Rezeptoren. Histamin findet somit nicht mehr genügend freie Bindungsstellen, um seine Wirkungen (z. B. Hautrötung, Juckreiz, Blutdruckabfall und Bronchospasmen) auszuüben. Als Vertreter der 2. Generation der H1-Antihistaminika ist Loratadin weitgehend frei von Nebenwirkungen auf das Zentralnervensystem, wie z. B. Sedierung. Ursache ist der Rücktransport der Substanz durch permeable Glykoproteine an der Blut-Hirn-Schranke.[5] Durch die Veresterung der Säuregruppe wird zudem eine gute Resorption ermöglicht. Loratadin wird im Organismus rasch zu Desloratadin abgebaut, das jedoch eine drei- bis vierfach höhere Affinität zum H1-Rezeptor besitzt. Daher kann Loratadin formal als Prodrug des Desloratadins angesehen werden. Beide Substanzen wirken zudem als FIASMA (funktioneller Hemmer der sauren Sphingomyelinase).[6]
Die Plasmahalbwertszeit liegt bei ca. acht Stunden, die der Metaboliten bei 12 bis 24 Stunden.

Neben unspezifischen Nebenwirkungen wie Kopfschmerz, Müdigkeit und Störungen des Magen-Darm-Traktes treten gelegentlich Mundtrockenheit und in Einzelfällen Haarausfall, Leberfunktionsstörungen und allergische Reaktionen auf. Vereinzelt werden auch Herzrhythmusstörungen beobachtet. In seltenen Fällen kann es auch zu Tinnitus kommen.[7]

Loratadin wird über das Enzym CYP3A4 abgebaut.[8] Bei gleichzeitiger Einnahme von Mitteln, die das Enzym CYP3A4 hemmen oder ähnliche Nebenwirkungen haben, zum Beispiel Ketoconazol, Erythromycin, Makrolid-Antibiotika, HIV-Proteaseinhibitoren, Propafenon und Grapefruitsaft, können die genannten Nebenwirkungen verstärkt werden, insbesondere Herzrhythmusstörungen.[9][10]

Nach dem Auslaufen der Patentfrist für die Herstellung von Loratadin entstand ein größerer Rechtsstreit: Schering-Plough verklagte Geneva Pharmaceuticals für die Herstellung von Loratadin-Generika basierend auf der Argumentation, dass Schering-Plough ein noch gültiges Patent auf die künstliche Herstellung des Loratadin-Metaboliten Descarboethoxyloratadin (Desloratadin) habe. Da die Einnahme von Loratadin beim Menschen auch zur Bildung von Descarboethoxyloratadin führe, verletze die Herstellung von Loratadin dieses Patent. Das US-Bundesberufungsgericht entschied zugunsten von Geneva, was zu starken Bedenken bei Pharmaunternehmen über die Schutzmöglichkeiten ihrer Produkte führte.[11] Tatsächlich sei der therapeutische Vorteil von Desloratadin gegenüber Loratadin aber entsprechend marginal[12], so dass bei großer zeitlicher Nähe zwischen dem Wegfall des Patentschutzes für Loratadin und der Markteinführung von Desloratadin[13] Kritik an einem Evergreening des Medikamentes geübt wurde.

Allernon (A), Claritine (CH), Clarityn (A) und diverse Generika (D, A, CH)

weißes bis fast weißes, polymorphes, kristallines Pulver[1]

R06AX13

Systemische Antihistaminika

Antagonist an Histamin-H1-Rezeptoren

fest

drug loratadine 10 mg

134–136 °C[2]

> 5 g·kg−1 (LD50, Ratte, oral)[3]

Allernon (A), Claritine (CH), Clarityn (A) und diverse Generika (D, A, CH)

weißes bis fast weißes, polymorphes, kristallines Pulver[1]

R06AX13

Systemische Antihistaminika

Antagonist an Histamin-H1-Rezeptoren

fest

drug loratadine 10 mg

134–136 °C[2]

> 5 g·kg−1 (LD50, Ratte, oral)[3]

Allernon (A), Claritine (CH), Clarityn (A) und diverse Generika (D, A, CH)

Medically reviewed by Sophia Entringer, PharmD Last updated on Jan 3, 2019.

Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Loratadine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Loratadine is also used to treat skin hives and itching in people with chronic skin reactions.

drug loratadine 10 mg

You should not take this medication if you are allergic to loratadine or to desloratadine (Clarinex).

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Some chewable dosage forms of loratadine may contain phenylalanine. Talk to your doctor before using these forms of loratadine if you have phenylketonuria (PKU).

Ask a doctor or pharmacist before taking this medicine if you have liver or kidney disease.

You should not take this medicine if you are allergic to loratadine or to desloratadine (Clarinex).

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions, especially:

asthma;

kidney disease; or

liver disease.

Loratadine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Loratadine can pass into breast milk, but is considered compatible with breastfeeding. Tell your doctor if you are breast-feeding a baby.

Some forms of loratadine may contain phenylalanine. Talk to your doctor before taking loratadine if you have phenylketonuria (PKU).

Use loratadine exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medicine to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Loratadine is usually taken once per day. Follow your doctor’s instructions.

Do not crush, chew, or break the regular tablet. Swallow the pill whole.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

The chewable tablet must be chewed before you swallow it.

To take the orally disintegrating tablet (Claritin RediTab, Alavert):

Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.

Use dry hands to remove the tablet and place it in your mouth.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, or if they get worse.

Store at room temperature away from moisture and heat.

Loratadine dosage information (in more detail)

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, drowsiness, and fast or pounding heartbeat.

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have signs of an allergic reaction to loratadine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using loratadine and call your doctor at once if you have:

fast or uneven heart rate;

severe headache; or

a light-headed feeling, like you might pass out;

Common loratadine side effects may include:

drug loratadine 10 mg

headache;

feeling tired or drowsy;

stomach pain, vomiting;

dry mouth; or

feeling nervous or hyperactive.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Loratadine side effects (in more detail)

Usual Adult Dose of Loratadine for Allergic Rhinitis:

10 mg orally once a day

Usual Adult Dose for Urticaria:

10 mg orally once a day

Usual Pediatric Dose for Allergic Rhinitis:

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)

Usual Pediatric Dose for Urticaria:

2 to 5 years: 5 mg orally once a day (syrup)

6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)

Other drugs may interact with loratadine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Loratadine drug interactions (in more detail)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use loratadine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 9.02.

Medical Disclaimer

Other brands: Claritin, Alavert, Claritin Reditabs, Children’s Claritin Allergy

Use these dosage charts for infants and children under 12 years old:

prednisone, cetirizine, montelukast, Benadryl, promethazine, triamcinolone, Zyrtec, diphenhydramine, Phenergan, Xolair

Loratadine reviews

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more.

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 Aug 2019), Cerner Multum™ (updated 1 Aug 2019), Wolters Kluwer™ (updated 31 July 2019) and others.

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Medically reviewed by Drugs.com. Last updated on Feb 20, 2019.

Applies to the following strengths: 10 mg; 5 mg/5 mL; 5 mg

10 mg orally once a day
-Maximum dose: 10 mg/day

Use: Temporary relief of symptoms associated with hay fever or other upper respiratory allergies (e.g., runny nose, itchy, watery eyes, sneezing, itching of the nose/throat)

10 mg orally once a day
-Maximum dose: 10 mg/day

Use: Temporary relief of symptoms associated with hay fever or other upper respiratory allergies (e.g., runny nose, itchy, watery eyes, sneezing, itching of the nose/throat)

2 to 5 years: 5 mg orally once a day
-Maximum dose: 5 mg/day

6 years and older: 10 mg orally once a day
-Maximum dose: 10 mg/day

Use: Temporary relief of symptoms associated with hay fever or other upper respiratory allergies (e.g., runny nose, itchy, watery eyes, sneezing, itching of the nose/throat)

drug loratadine 10 mg

2 to 5 years: 5 mg orally once a day
-Maximum dose: 5 mg/day

6 years and older: 10 mg orally once a day
-Maximum dose: 10 mg/day

Use: Temporary relief of symptoms associated with hay fever or other upper respiratory allergies (e.g., runny nose, itchy, watery eyes, sneezing, itching of the nose/throat)

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Data not available.

Administration advice:
-This drug may be taken with or without food.
-Oral solution formulations should be used with the enclosed dosing cup.
-Oral dissolving tablets (ODTs)/oral lyophilisates should be opened immediately before placement on the tongue; the tablet should be allowed to dissolve and may be taken with or without water.

Storage requirements:
-Liquid filled capsules: Keep from freezing.
-Chewable, oral lyophilisates, and ODTs: Store unopened blister packs at 20 to 25C.
-Oral tablets: Protect from moisture.

Patient advice:
-Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery until the full effects of the drug are seen

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Other brands: Claritin, Alavert, Claritin Reditabs, Wal-itin, … +6 more

Use these dosage charts for infants and children under 12 years old:

prednisone, loratadine, cetirizine, montelukast, Benadryl, promethazine, triamcinolone, Zyrtec, diphenhydramine, Xolair

Loratadine reviews

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

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Applies to loratadine: oral fixed-combination tablets, oral orally disintegrating tablets, oral solution, oral tablets

Side effects include:

Children 2–5 years of age receiving oral solution: Diarrhea, epistaxis, pharyngitis, flu-like symptoms, fatigue, stomatitis, tooth disorder, earache, viral infection, rash.

Children 6–12 years of age receiving oral solution: Nervousness, wheezing, fatigue, hyperkinesia, abdominal pain, conjunctivitis, dysphonia, upper respiratory tract infection.

drug loratadine 10 mg

Adults and children ≥12 years of age receiving conventional or orally disintegrating tablets: Headache, somnolence, fatigue, dry mouth.

Fixed combination loratadine/pseudoephedrine sulfate preparations: Insomnia, dry mouth, headache, somnolence, nervousness, dizziness, fatigue.

Applies to loratadine: oral capsule, oral syrup, oral tablet, oral tablet chewable, oral tablet disintegrating

The most commonly reported side effects included headache, somnolence nervousness, and fatigue.[Ref]

Very common (10% or more): Headache (up to 12%)

Common (1% to 10%): Sedation/somnolence

Very rare (less than 0.01%): Dizziness, convulsion

Frequency not reported: Syncope, paresthesia[Ref]

Common (1% to 10%): Nervousness

Uncommon (0.1% to 1%): Insomnia

Frequency not reported: Depression, paroniria[Ref]

Common (1% to 10%): Fatigue

Frequency not reported: Fever, viral infection, tinnitus, malaise[Ref]

Common (1% to 10%): Dry mouth

Very rare (less than 0.01%): Nausea, gastritis

Frequency not reported: Dyspepsia, diarrhea, constipation, abdominal/gastric pain, altered taste, increased saliva[Ref]

Uncommon (0.1% to 1%): Increased appetite[Ref]

Very rare (less than 0.01%): Angioedema, rash, alopecia

Frequency not reported: Pruritus, rash on face[Ref]

Frequency not reported: Increased frequency of urination, urine discoloration, menstruation delay[Ref]

Very rare (less than 0.01%): Tachycardia, palpitation

Frequency not reported: Hypertension, hypotension, chest pain[Ref]

Very rare (less than 0.01%): Hypersensitivity reactions, anaphylaxis[Ref]

Very rare (less than 0.01%): Abnormal hepatic function[Ref]

Frequency not reported: Epistaxis, nasal dryness, pharyngitis, coughing[Ref]

Frequency not reported: Myalgia[Ref]

1. Cerner Multum, Inc. “UK Summary of Product Characteristics.” O 0

2. Cerner Multum, Inc. “Australian Product Information.” O 0

3. “Product Information. Claritin (loratadine).” Schering Laboratories, Kenilworth, NJ.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer

Other brands: Claritin, Alavert, Claritin Reditabs, Wal-itin, … +6 more

Use these dosage charts for infants and children under 12 years old:

prednisone, loratadine, cetirizine, montelukast, Benadryl, promethazine, triamcinolone, Zyrtec, diphenhydramine, Xolair

drug loratadine 10 mg

Loratadine reviews

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A total of 65 drugs are known to interact with loratadine.

Show all medications in the database that may interact with loratadine.

Type in a drug name to check for interactions with loratadine.

View interaction reports for loratadine and the medicines listed below.

There is 1 alcohol/food interaction with loratadine

drug loratadine 10 mg

There is 1 disease interaction with loratadine:

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Some mixtures of medications can lead to serious and even fatal consequences.

Here are 9 ways to stay safe

Use these dosage charts for infants and children under 12 years old:

prednisone, cetirizine, montelukast, Benadryl, promethazine, triamcinolone, Zyrtec, diphenhydramine, Phenergan, Xolair

Loratadine reviews

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

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Medically reviewed by Drugs.com. Last updated on Dec 2, 2018.

Because of its lack of sedation and low milk levels, maternal use of loratadine would not be expected to cause any adverse effects in breastfed infants. Loratadine might have a negative effect on lactation, especially in combination with a sympathomimetic agent such as pseudoephedrine. The British Society for Allergy and Clinical Immunology recommends loratadine at its lowest dose as a preferred choice if an antihistamine is required during breastfeeding.[1]

drug loratadine 10 mg

After a single oral dose of 40 mg of loratadine in 6 women, average peak milk levels of 29.2 (range 20.4 to 39) mcg/L occurred at two hours after the dose. In addition, average desloratadine peak milk levels of 16 (range 9 to 29.6) mcg/L occurred at 5.3 hours after the dose. The total amount excreted in milk over 48 hours was 11.7 mcg of loratadine and its metabolite. However, the dose administered was four times greater than the usual dose of the drug, so a total dose of about 3 mcg would be expected with a 10 mg dose. The calculated average and maximum expected doses of loratadine plus desloratadine in milk were 0.46 and 1.1% and of the maternal weight-adjusted dose, respectively, after the 40 mg dose.[2]

A survey of 51 mothers who took loratadine during breastfeeding between 1999 and 2001 was conducted by a teratogen information service. Most of the infants were over 2 months old and loratadine was generally taken for one week or less. Two mothers reported minor sedation in their infants, one at 3 days of age and one at 3 months of age. Both mothers were taking a dose of 10 mg daily. Weight gain and psychomotor development were similar to infants in a control group of breastfed infants unexposed to medications.[3] An extension of the study that compared the results of this study (plus one additional patient) to that of a control group of 88 mothers who took a drug known to be safe while breastfeeding. No differences in sedation or any other side effects (p=0.606) in the infant were found between mothers who took loratadine during breastfeeding and those of the control group.[4]

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[5][6] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[5] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

One mother out of 51 mothers who took loratadine while nursing reported that she had decreased milk production after taking loratadine 10 mg daily for less than one week at 4 months postpartum.[3]

Desloratadine, Fexofenadine

1. Powell RJ, Du Toit GL, Siddique N et al. BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007;37:631-50. PMID: 17456211

2. Hilbert J, Radwanski E, Affine MB et al. Excretion of loratadine in human breast milk. J Clin Pharmacol. 1988;28:234-9. PMID: 2966185

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Merlob P, Stahl B. Prospective follow-up of adverse reactions in breast-fed infants exposed to loratadine treatment (1999-2001). BELTIS Newsl. 2002;Number 10:43-51.

5. Merlob P. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal loratadine treatment (1999-2002). Unpublished manuscript.

6. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Loratadine

79794-75-5

Breast Feeding

Lactation

Antihistamines

Nonsedating Antihistamines

163

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Other brands: Claritin, Alavert, Claritin Reditabs, Wal-itin, … +6 more

Use these dosage charts for infants and children under 12 years old:

Loratadine reviews

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drug loratadine 10 mg

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Applies to the following strengths: 10 mg; 5 mg/5 mL; 5 mg

10 mg orally once a day
-Maximum dose: 10 mg/day

Use: Temporary relief of symptoms associated with hay fever or other upper respiratory allergies (e.g., runny nose, itchy, watery eyes, sneezing, itching of the nose/throat)

10 mg orally once a day
-Maximum dose: 10 mg/day

Use: Temporary relief of symptoms associated with hay fever or other upper respiratory allergies (e.g., runny nose, itchy, watery eyes, sneezing, itching of the nose/throat)

2 to 5 years: 5 mg orally once a day
-Maximum dose: 5 mg/day

6 years and older: 10 mg orally once a day
-Maximum dose: 10 mg/day

Use: Temporary relief of symptoms associated with hay fever or other upper respiratory allergies (e.g., runny nose, itchy, watery eyes, sneezing, itching of the nose/throat)

drug loratadine 10 mg

2 to 5 years: 5 mg orally once a day
-Maximum dose: 5 mg/day

6 years and older: 10 mg orally once a day
-Maximum dose: 10 mg/day

Use: Temporary relief of symptoms associated with hay fever or other upper respiratory allergies (e.g., runny nose, itchy, watery eyes, sneezing, itching of the nose/throat)

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Data not available.

Storage requirements:
-Liquid filled capsules: Keep from freezing.
-Chewable, oral lyophilisates, and ODTs: Store unopened blister packs at 20 to 25C.
-Oral tablets: Protect from moisture.

Patient advice:
-Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery until the full effects of the drug are seen

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Other brands: Claritin, Alavert, Claritin Reditabs, Wal-itin, … +6 more

Use these dosage charts for infants and children under 12 years old:

prednisone, loratadine, cetirizine, montelukast, Benadryl, promethazine, triamcinolone, Zyrtec, diphenhydramine, Xolair

Loratadine reviews

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more.

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synonym: Loratadinum PhEur

Loratadin ist in Form von Tabletten im Handel (Claritine®, Claritine® Pollen, Generika). Es ist in der Schweiz seit 1991 zugelassen. Der aktive Metabolit Desloratadin ist ebenfalls erhältlich (Aerius®, Generika).

Loratadin (C22H23ClN2O2, Mr = 382.9 g/mol) liegt als weisses, kristallines Pulver vor, das in Wasser praktisch unlöslich ist. Es ist ein Prodrug und wird unter anderem zu Desloratadin (Descarboethoxyloratadin) und anderen Metaboliten biotransformiert. Loratadin ist mit anderen Antihistaminika wie Cyproheptadin und mit trizyklischen Antidepressiva strukturell verwandt.

Loratadin (ATC R06AX13 ) hat antihistamine und antiallergische Eigenschaften und ist weniger sedierend als Antihistaminika der 1. Generation. Es ist nicht anticholinerg oder kardiotoxisch wie Astemizol oder Terfenadin. Die Effekte beruhen auf dem selektiven Antagonismus an Histamin-H1-Rezeptoren.

drug loratadine 10 mg

Gemäss der Packungsbeilage. Da Loratadin und sein aktiver Metabolit eine lange Halbwertszeit haben, reicht eine einmal tägliche Verabreichung aus. Bei nüchterner Einnahme tritt die Wirkung schneller ein.

Die vollständigen Vorsichtsmassnahmen finden sich in der Arzneimittel-Fachinformation.

Loratadin wird von CYP3A4 und CYP2D6 biotransformiert. Entsprechende Arzneimittel-Wechselwirkungen sind möglich. Die Effekte von Alkohol werden laut der Fachinformation nicht verstärkt.

Zu den häufigsten möglichen unerwünschten Wirkungen gehören:

Antihistaminika, Heuschnupfen, Desloratadin

Interessenkonflikte: Keine / unabhängig. Der Autor hat keine Beziehungen zu den Herstellern und ist nicht am Verkauf der erwähnten Produkte beteiligt.

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Loratadine is an antihistamine medicine that relieves the symptoms of allergies. It’s used to treat:

It’s also used for reactions to insect bites and stings and for some food allergies.

Loratadine is known as a non-drowsy antihistamine. It’s much less likely to make you feel sleepy than some other antihistamines.

drug loratadine 10 mg

Loratadine is available on prescription. You can also buy it from pharmacies and supermarkets.

It comes as tablets or as a liquid that you swallow.

Loratadine can be taken by adults and children aged 2 years and older.

Loratadine isn’t suitable for some people. Tell your doctor or pharmacist if you:

If you or your child have been prescribed loratadine, follow your
doctor’s instructions about how and when to take it. If you’ve bought
loratadine from a pharmacy or shop, follow the instructions that come
with the packet.

Loratadine comes as 10mg tablets and as a liquid medicine (labelled
either 5mg/5ml or 1mg/1ml). You can take loratadine with or without
food.

The usual dose in adults is 10mg once a day.

Doses are usually lower for people with liver problems.

For children, your doctor will use your child’s weight or age to work out the right dose.

Loratadine comes as 2 different types of tablet – ordinary and melt-in-the-mouth tablets.

Swallow ordinary loratadine tablets with a drink of water, milk or
juice. If the tablet has a score line, you can break it in half if you
find it hard to swallow it whole. Do not chew it.

Melt-in-the-mouth tablets dissolve instantly on your tongue without
needing a drink. Be careful not to crush them when you take them out of
the packet.

Loratadine liquid may be easier for children to take than tablets.
The medicine will come with a plastic syringe or spoon to help you
measure out the right dose. If you don’t have a syringe or spoon, ask
your pharmacist for one. Do not use a kitchen teaspoon as it will not
give the right amount.

Loratadine tablets and melt-in-the-mouth tablets must only be taken
by children aged between 2 and 12 years if they weigh 30kg or more. Give children loratadine liquid if they weigh less than 30kg.

You may only need to take loratadine on a day you have symptoms, for instance if you’ve been exposed to a trigger such as animal hair. Or you may need to take it regularly to prevent symptoms, such as hay fever during
spring and summer.

Take your forgotten dose as soon as you remember, unless it is nearly time for your next dose. Do not take a double dose to make up for a forgotten dose.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

Loratadine is generally very safe. Taking too much is unlikely to harm you or your child.

If you take an extra dose by mistake, you might get a headache, have a rapid heartbeat or feel sleepy. If this happens or you’re concerned, contact your doctor.

Like all medicines, loratadine can cause side effects although not everyone gets them.

The most common side effect of loratadine is feeling sleepy. This happens in more than 1 in 100 people.

Side effects in children may include:

In rare cases, loratadine may cause a serious allergic reaction (anaphylaxis).

These are warning signs of a serious allergic reaction. A serious allergic reaction is an emergency.

These are not all the side effects of loratadine. For a full list see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

What to do about:

It’s generally safe to take loratadine during pregnancy and while breastfeeding.

For more information about how loratadine can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.

It’s usually safe to take loratadine if you’re breastfeeding as only small amounts get into breast milk.

If you’re breastfeeding and your baby was premature or has other health problems, talk to your doctor before taking loratadine.

Some medicines and loratadine interfere with each other and increase the chances of you having side effects.

Tell your doctor if you’re taking:

There might be a problem taking some herbal remedies and supplements
alongside loratadine – especially ones that cause sleepiness, a dry
mouth or make it difficult to pee.

Loratadine is a medicine called an antihistamine.

drug loratadine 10 mg

When you come into contact with something you have an allergy to, such as pollen, animal hair or fur, house dust or insect bites, your body produces a chemical called histamine.

Usually histamine is a useful substance but in an allergic reaction it causes unpleasant symptoms including itchy, watery eyes, running or blocked nose, sneezing and skin rashes.

Loratadine blocks the effects of histamine and so reduces these symptoms.

You should start to feel better within an hour.

It depends on why you’re taking it.

You may only need to take loratadine for a short time or as a one-off dose. If you have a reaction to an insect bite, you may only need to take loratadine for a day or two.

You may need to take it for longer if you’re taking it to prevent symptoms from hay fever when the pollen count is high.

Talk to your doctor or pharmacist if you’re not sure how long you need to take loratadine for.

Loratadine is unlikely to do you any harm if you take it for a long time. However, it’s best to take loratadine only for as long as you need to.

It’s best not to drink alcohol while you’re taking loratadine, as it can make you feel sleepy.

You can eat and drink normally while taking loratadine.

Loratadine is classed as a non-drowsy antihistamine but it’s still possible to feel sleepy after taking it.

If this happens to you, do not drive a car or ride a bike until you feel better.

Loratadine is known as a non-drowsy antihistamine. It’s less likely to make you feel sleepy than other, so-called, sedating
antihistamines such as Piriton (chlorphenamine).

Most people prefer to take a non-drowsy antihistamine instead of a sedating one. One exception may be when you want the medicine to make you sleepy because you’ve got itchy skin that’s keeping you awake.

Other non-drowsy antihistamines like cetirizine, desloratadine, fexofenadine and levocetirizine seem to work as well as loratadine.

However, loratadine, desloratadine and fexofenadine seem to be less likely to make you feel sleepy than cetirizine.

Yes, you can take loratadine together with paracetamol or ibuprofen.

Sometimes doctors recommend that people with severe itchy skin rash take 2 different antihistamines together for a few days.

As well as taking a non-drowsy antihistamine like loratadine during the day, your doctor may tell you to take a sedating antihistamine at night if the itching is making it difficult to sleep.

Do not take 2 antihistamines together unless recommended by your doctor.

Yes, it’s fine to take loratadine together with other types of hay fever treatment, for example steroid nasal sprays (such as Beconase, Rhinacort Aqua and Flixonase Nasules), or eyedrops.

Your doctor might suggest you or your child take a higher dose of loratadine (up to 4 times the usual dose) for severe itchy skin rash or swelling underneath the skin (angioedema).

Taking high doses of loratadine isn’t suitable for everyone though.

Speak to your doctor if you think loratadine isn’t working for you.

There’s no firm evidence to suggest that taking loratidine will reduce fertility in either men or women. However, speak to a pharmacist or your doctor before taking it if you’re trying to get pregnant.

Loratadine will not affect contraception including the contraceptive pill or emergency contraception.

It will help if you don’t spend too much time outside if the pollen count is high.

Tips for when you’re outside

Tips for when you’re inside

Page last reviewed: 19 October 2018
Next review due: 19 October 2021

This leaflet is about the use of loratadine to reduce the symptoms of allergy, such as in hay fever, urticaria (itchy rash) or pruritis (itchy skin).

This leaflet has been written for parents and carers about how to use this medicine in children. Our information sometimes differs from that provided by the manufacturers, because their information is usually aimed at adult patients. Please read this leaflet carefully. Keep it somewhere safe so that you can read it again.

LoratadineCommon brands: Clarityn Allergy® or Clarityn Rapide Allergy®.

Loratadine is a medicine known as an antihistamine. When the body comes into contact with something it is allergic to, such as pollen, animal hair or fur, house dust or insect bites,
it produces a chemical called histamine. This causes itchy, watery eyes, running or blocked nose, sneezing and rashes. Loratadine blocks the effects of histamine
and so reduces these symptoms.

Most children only need to take an antihistamine for a short while when they have symptoms of allergy.

drug loratadine 10 mg

In some children, loratadine is used only when it is needed (e.g. when they are exposed to a trigger such as animal hair). In other children, it is used regularly (e.g. for hay fever during spring or summer). Loratadine should be stopped once it is no longer needed.

Give the medicine at about the same time(s) each day so that this becomes part of your child’s daily routine, which will help you to remember.

Your doctor will work out the amount of loratadine (the dose) that is right for your child. The dose will be shown on the medicine label if you have been given a prescription.

If you have bought your medicine over the counter, then please follow the instructions on the package carefully. If you are not sure how much to give, then contact your pharmacist or doctor.

It is important that you follow your doctor’s instructions about how much to give.

Tablets should be swallowed with a glass of water, milk or juice. Your child should not chew the tablet.

Liquid medicine: Measure out the right amount using a medicine spoon or oral syringe. You can get these from your pharmacist. Do not use a kitchen teaspoon as it will not give the right amount.

Loratadine usually starts to work straight away. If your child has been in contact with something they are allergic to and has symptoms, the symptoms should go away within 30 to
60 minutes, but if the medicine is being used to prevent an allergic reaction you may not see much difference in your child.

If your child is sick again, seek advice from your GP, pharmacist or hospital. They will decide what to do based on your child’s condition and the specific medicine involved.

If you normally give it once a day in the morning

You are unlikely to do harm if you give an extra dose of loratadine by mistake. If you are concerned that you may have given too much, contact your doctor or local NHS services (111 in England and Scotland; 0845 4647 in Wales). Have the medicine or packaging with you if you telephone for advice.

We use medicines to make our children better, but sometimes they have other effects that we don’t want (side-effects).

Your child is unlikely to get side-effects with loratadine. If the following side-effects do occur, they are usually mild and wear off after a few days. If they are still a problem after a week, consult your doctor.

There may, sometimes, be other side-effects that are not listed above. If you notice anything unusual and are concerned, contact your doctor. You can report any suspected side-effects to a UK safety scheme at www.mhra.gov.uk/yellowcard.
More information on side-effects can be found in the following leaflet www.medicinesforchildren.org.uk/side-effects-childrens-medicines

If your child has epilepsy, check with your doctor before you give them loratadine as it may increase the chance of your child having a seizure (fit).

Your child’s doctor, pharmacist or nurse will be able to give you more information about loratadine and about other medicines used to treat allergy with sneezing, wheezing or itching.

The primary source for the information in this leaflet is the British National Formulary for Children. For details on any other sources used for this leaflet, please contact us through our website, www.medicinesforchildren.org.uk

We take great care to make sure that the information in this leaflet is correct and up-to-date. However, medicines can be used in different ways for different patients. It is important that you ask the advice of your doctor or pharmacist if you are not sure about something. This leaflet is about the use of these medicines in the UK, and may not apply to other countries. The Royal College of Paediatrics and Child Health (RCPCH), the Neonatal and Paediatric Pharmacists Group (NPPG), WellChild and the contributors and editors cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this leaflet.