خواص دارویی و گیاهی
POM: Preion only medicine
This information is intended for use by health professionals
Posology
Hypertension
Heart failure
Reduction in the risk of stroke in hypertensive patients with left ventricular hypertrophy ed by ECG
Special populations
Use in patients with intravascular volume depletion
Use in patients with renal impairment and haemodialysis patients
Use in patients with hepatic impairment
Paediatric population
Use in elderly
Method of administration
Hypersensitivity
Hypotension and electrolyte/fluid imbalance
Electrolyte imbalances
Hepatic impairment
Renal impairment
Use in paediatric patients with renal impairment
Renal transplantation
Primary hyperaldosteronism
Coronary heart disease and cerebrovascular disease
Heart failure
Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy
Pregnancy
Other warnings and precautions
Pregnancy
Lactation
Table 1. The frequency of adverse reactions identified from placebo-controlled clinical studies and post marketing experience
Paediatric population
Symptoms of intoxication
Treatment of intoxication
Hypertension studies
LIFE-study
Race
RENAAL-study
HEAAL Study
ELITE I and ELITE II study
Paediatric Population
Paediatric hypertension
Absorption
Distribution
Biotransformation
Elimination
Characteristics in patients
Pharmacokinetics in paediatric patients
Tablet core:
HDPE Bottle:
Blisters:
Bottles:
Pack sizes:
2 Frimley Business Park, Frimley, Camberley, Surrey, GU16 7SR, UK
+44 () 1276 6982
sandoz@professionalinformation.co.uk
http://www.sandoz.com
+44 ()1276 698 11
To bookmark a medicine you must sign up and log in.
To email a medicine you must sign up and log in.
To view the changes to a medicine you must sign up and log in.
This site uses cookies. By continuing to browse the site you are agreeing to our policy on the use of cookies.
Continue
(losartan)
Losartan belongs to a family of medications known as angiotensin II receptor blockers. These medications are used in adults and children over the age of six to lower mild-to-moderate hypertension (high blood pressure).
Angiotensin II is a chemical that the body releases to cause the constriction of blood vessels. Losartan blocks the action of angiotensin II, resulting in the relaxation of the blood vessels. This relaxation causes the blood pressure to drop. The full effects of losartan are usually seen within 3 to 6 weeks after treatment has started. Losartan may be used alone or in combination with a diuretic (water pill).
Losartan may also be taken by adults who have type 2 diabetes along with hypertension and protein in the urine (proteinuria). In these cases, losartan is used to protect the kidneys from further damage due to diabetes.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
25 mg
Each white, oval, unscored, film-coated tablet engraved with “25” on one side and nothing on the other, contains 25 mg losartan as losartan potassium. Nonmedicinal ingredients: colloidal anhydrous silica, hydroxypropyl cellulose, hypromellose, lactose monohydrate, macrogol 4, magnesium stearate, microcrystalline cellulose, pregelatinized starch, talc, and colouring agent (titanium dioxide).
5 mg
Each white, oval, unscored, film-coated tablet engraved with “5” on one side and nothing on the other, contains 5 mg losartan as losartan potassium. Nonmedicinal ingredients: colloidal anhydrous silica, hydroxypropyl cellulose, hypromellose, lactose monohydrate, macrogol 4, magnesium stearate, microcrystalline cellulose, pregelatinized starch, talc, and colouring agent (titanium dioxide).
1 mg
Each white, teardrop-shaped, unscored, film-coated tablet engraved with “1” on one side and nothing on the other, contains 1 mg losartan as losartan potassium. Nonmedicinal ingredients: colloidal anhydrous silica, hydroxypropyl cellulose, hypromellose, lactose monohydrate, macrogol 4, magnesium stearate, microcrystalline cellulose, pregelatinized starch, talc, and colouring agent (titanium dioxide).
The usual recommended dose of losartan for adults is 5 mg or 1 mg once daily. The usual starting dose is 5 mg once daily. In some cases, a lower starting dose of 25 mg once daily may be advisable. A dose of 1 mg once daily should not be exceeded. Your doctor will adjust the dosage according to individual needs.
The usual recommended dose of losartan for children, aged 6 – 16 years, is based on body weight. The dose is 25 mg once daily for children weighing between 2 kg and 49 kg. This dose may be increased to 5 mg once daily. In children weighing more than 5 kg, the starting dose is 5 mg taken once daily. This dose may be increased to 1 mg once daily.
Losartan may be taken with or without food, but should be taken the same way each day.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Losartan should not be taken by anyone who:
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Health Canada has issued new restrictions concerning the use of losartan. To read the full Health Canada Advisory, visit Health Canada’s web site at www.hc-sc.gc.ca.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood pressure: Occasionally, a larger-than-expected drop in blood pressure occurs after taking losartan, in some cases after the first dose. It is more likely to occur if you take diuretics (water pills), have reduced salt intake, are on dialysis, or are experiencing diarrhea or vomiting. Blood pressure should be checked more often in these situations. If you have low blood pressure or are just starting to take this medication, you should move slowly when you are rising from a reclining to an upright position to reduce the risk of dizziness.
Dizziness: Losartan may cause dizziness, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how this medication affects you.
Kidney problems: The use of losartan may affect the of the kidneys, especially for those who already have kidney problems. Certain people have experienced changes in kidney (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills), nonsteroidal anti-inflammatory drugs (NSAIDs) or aliskiren may further increase risk of kidney problems for people already at risk for this problem. If you have kidney problems, your doctor will likely closely monitor your condition while you are taking this medication.
Liver : Losartan is removed from the body by the liver. Liver disease or reduced liver may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver regularly with blood tests while you are taking this medication.
Pregnancy: Losartan should not be taken by pregnant women as it can cause harm to an unborn child. If you are planning to become pregnant, discuss alternative medications for blood pressure control with your doctor.
If you become pregnant while taking this medication, stop taking it and tell your doctor at once.
Breast-feeding: It is not known if losartan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children less than 6 years of age.
There may be an interaction between losartan and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all preion, over-the-counter (non-preion), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 218. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Sandoz-Losartan
(losartan)
Losartan belongs to a family of medications known as angiotensin II receptor blockers. These medications are used in adults and children over the age of six to lower mild-to-moderate hypertension (high blood pressure).
Angiotensin II is a chemical that the body releases to cause the constriction of blood vessels. Losartan blocks the action of angiotensin II, resulting in the relaxation of the blood vessels. This relaxation causes the blood pressure to drop. The full effects of losartan are usually seen within 3 to 6 weeks after treatment has started. Losartan may be used alone or in combination with a diuretic (water pill).
Losartan may also be taken by adults who have type 2 diabetes along with hypertension and protein in the urine (proteinuria). In these cases, losartan is used to protect the kidneys from further damage due to diabetes.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
25 mg
Each white-to-off-white, oval, biconvex, film-coated tablet debossed with “E” on one side and “45” on other, contains 25 mg losartan as losartan potassium. Nonmedicinal ingredients: cellulose microcrystalline, lactose monohydrate, starch pregelatinised, low-substituted hydroxypropyl cellulose, magnesium stearate, and opadry white 2A589.
5 mg
Each white-to-off-white, oval, biconvex, film-coated tablet debossed with “E” on one side and “4” and “6” separated by scoreline on other side, contains 5 mg losartan as losartan potassium. Nonmedicinal ingredients: cellulose microcrystalline, lactose monohydrate, starch pregelatinised, low-substituted hydroxypropyl cellulose, magnesium stearate, and opadry white 2A589.
1 mg
Each white-to-off-white, oval, biconvex, film-coated tablet debossed with “E” on one side and “47” on other, contains 1 mg losartan as losartan potassium. Nonmedicinal ingredients: cellulose microcrystalline, lactose monohydrate, starch pregelatinised, low-substituted hydroxypropyl cellulose, magnesium stearate, and opadry white 2A589.
The usual recommended dose of losartan for adults is 5 mg or 1 mg once daily. The usual starting dose is 5 mg once daily. In some cases, a lower starting dose of 25 mg once daily may be advisable. A dose of 1 mg once daily should not be exceeded. Your doctor will adjust the dosage according to individual needs.
The usual recommended dose of losartan for children, aged 6 – 16 years, is based on body weight. The dose is 25 mg once daily for children weighing between 2 kg and 49 kg. This dose may be increased to 5 mg once daily. In children weighing more than 5 kg, the starting dose is 5 mg taken once daily. This dose may be increased to 1 mg once daily.
Losartan may be taken with or without food, but should be taken the same way each day.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Losartan should not be taken by anyone who:
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Health Canada has issued new restrictions concerning the use of losartan. To read the full Health Canada Advisory, visit Health Canada’s web site at www.hc-sc.gc.ca.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood pressure: Occasionally, a larger-than-expected drop in blood pressure occurs after taking losartan, in some cases after the first dose. It is more likely to occur if you take diuretics (water pills), have reduced salt intake, are on dialysis, or are experiencing diarrhea or vomiting. Blood pressure should be checked more often in these situations. If you have low blood pressure or are just starting to take this medication, you should move slowly when you are rising from a reclining to an upright position to reduce the risk of dizziness.
Dizziness: Losartan may cause dizziness, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how this medication affects you.
Kidney problems: The use of losartan may affect the of the kidneys, especially for those who already have kidney problems. Certain people have experienced changes in kidney (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills), nonsteroidal anti-inflammatory drugs (NSAIDs) or aliskiren may further increase risk of kidney problems for people already at risk for this problem. If you have kidney problems, your doctor will likely closely monitor your condition while you are taking this medication.
Liver : Losartan is removed from the body by the liver. Liver disease or reduced liver may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver regularly with blood tests while you are taking this medication.
Pregnancy: Losartan should not be taken by pregnant women as it can cause harm to an unborn child. If you are planning to become pregnant, discuss alternative medications for blood pressure control with your doctor.
If you become pregnant while taking this medication, stop taking it and tell your doctor at once.
Breast-feeding: It is not known if losartan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children less than 6 years of age.
There may be an interaction between losartan and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all preion, over-the-counter (non-preion), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 218. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Auro-Losartan
1