خواص دارویی و گیاهی
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Active substance(s): IBUPROFEN
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.قرص ibuprofen 200
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Ibuprofen USP, 200 mg (NSAID)**nonsteroidal anti-inflammatory drug
قرص ibuprofen 200
Pain reliever/fever reducer
Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
If an allergic reaction occurs, stop use and seek medical help right away.
Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
ask a health professional before use. It is especially important not to use ibuprofen during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.
Call 1-800-426-9391 8:30 AM-4:00 PM ET, Monday-Friday
VALUE SIZE Walgreens
Compare to Motrin® IB Caplets active ingredient††
NDC 0363-0393-14
Ibuprofen 200
Ibuprofen USP, 200 mg /PAIN RELIEVER/FEVER REDUCER (NSAID)
CAPLETS
500 CAPLETS**(**CAPSULE-SHAPED TABLETS)
TAMPER EVIDENT: DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING
50844 ORG061839314 ORG0618-F
DISTRIBUTED BY:WALGREEN CO. 200 WILMOT RD. DEERFIELD, IL 60015 100 % SATISFACTION GUARANTEED walgreens.com ©2018 Walgreen Co.
ITEM 907105
قرص ibuprofen 200
Walgreens 44-393
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IBUPROFEN- ibuprofen tablet, film coated L.N.K. International, Inc.
———-
Ibuprofen USP, 200 mg (NSAID)**nonsteroidal anti-inflammatory drug
قرص ibuprofen 200
Pain reliever/fever reducer
Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
If an allergic reaction occurs, stop use and seek medical help right away.
Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
ask a health professional before use. It is especially important not to use ibuprofen during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.
carnauba wax, colloidal silicon dioxide, corn starch, hypromellose, lactose anhydrous, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol, red iron oxide, sodium starch glycolate, stearic acid, titanium dioxide
Call 1-800-426-9391 8:30 AM-4:00 PM ET, Monday-Friday
Quality+ Plus
NDC 50844-291-15
†Compare to active ingredientin Advil® Tablets
IBUPROFEN TABLETSUSP, 200 mg
PAIN RELIEVER/FEVER REDUCER (NSAID)
50 Coated Tablets
ACTUALSIZE
TAMPER EVIDENT: DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING
†This product is not manufactured or distributed by Wyeth LLC, owner of the registered trademark Advil® Tablets.50844 REV0618A29115
Distributed by LNK INTERNATIONAL, INC. 60 Arkay Drive, Hauppauge, NY 11788USA
Quality Plus 44-291
قرص ibuprofen 200
Brupro Ibuprofen 200mg Tablets are used to lower fever and manage general pain such as back pain, headache, dental pain and period pain and to treat colds and flu. Each tablet contains 200mg of Ibuprofen.
You Must Be Aged Over 18 Years to Purchase This Product. MAXIMUM order quantity of 48 tablets per order.
Do not take with any other ibuprofen products.
Adults and children over 12 years take 2 tablets initially, then if necessary 1-2 tablets every 4 hours. Do not Exceed 5 tablets in 24-hours.
قرص ibuprofen 200
Each film coated tablet contains 200mg of ibuprofen.
Republic Of Ireland: Order by 4pm for NEXT WORKING DAY DELIVERY.
Delivery estimate times can be found here.
Collect in Store for Free in one of our pharmacy locations at Inish Pharmacy Carndonagh, Muff or Buncrana. You will receive an email when your order is ready for collection, which is usually within 1 working day.
*Terms and conditions apply, for more information read our Delivery information page.
Who can use?
This product is for use in adults and children over 12 years and over only.
How to use?
Adults and children over 12 years take 2 tablets initially, then if necessary 1-2 tablets every 4 hours. Do not exceed 5 tablets in 24-hours.
Not suitable for children under 12 years.
If you are pregnant or breastfeeding.
If you are pregnant do not take this medication unless advised by your doctor. It should not be taken in the last 3 months of pregnancy or while breastfeeding.
Driving and using machines
If you experience any side effects such as dizziness or disturbed vision you should not driving or using machinery.
Possible side effects
Like all medicines, this can cause side effects, although not everybody gets them. If you experience any serious side effects please consult your doctor.
KEEP ALL MEDICINES OUT OF THE REACH OF CHILDREN.
READ THE PATIENT LEAFLET BEFORE TAKING THIS MEDICATION.
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Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.7 The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin.8 Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.9
On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.24
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.قرص ibuprofen 200
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Ibuprofen is the most commonly used and prescribed NSAID. It is very common over the counter medication widely used as an analgesic, anti-inflammatory and antipyretic.11
The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.12
Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labor.10
As ibuprofen is a widely used medication, the main therapeutic indications are:
Patent Ductus Arteriosus – it is a neonatal condition wherein the ductus arteriosus (blood vessel that connects the main pulmonary artery to the proximal descending aorta) fails to close after birth causing severe risk of heart failure. The prostaglandin inhibition of ibuprofen has been studied for the treatment of this condition as it is known that prostaglandin E2 is responsible for keeping the ductus arteriosus open.13
Rheumatoid- and osteo-arthritis – ibuprofen is very commonly used in the symptomatic treatment of inflammatory, musculoskeletal and rheumatic disorders.14
Cystic fibrosis – the use of high dosages of ibuprofen has been proven to decrease inflammation and decreasing polymorphonuclear cell influx in the lungs.15
Orthostatic hypotension – ibuprofen can induce sodium retention and antagonize the effect of diuretics which has been reported to be beneficial for patients with severe orthostatic hypotension.1
Dental pain – ibuprofen is used to manage acute and chronic orofacial pain.16
Minor pain – ibuprofen is widely used to reduce minor aches and pains as well as to reduce fever and manage dysmenorrhea. It is very commonly used for the relief of acute indications such as fever and tension headaches.10
Investigational uses – efforts have been put into developing ibuprofen for the prophylaxis of Alzheimer’s disease, Parkinson disease, and breast cancer.10
Ibuprofen has multiple actions in different inflammatory pathways involved in acute and chronic inflammation. The main effects reported in ibuprofen are related to the control of pain, fever and acute inflammation by the inhibition of the synthesis of prostanoids by COX-1 and COX-2. Pain relief is attributed to peripheral affected regions and central nervous system effects in the pain transmission mediated by the dorsal horn and higher spinothalamic tract. Some reports have tried to link the pain regulation with a possible enhancement on the synthesis of endogenous cannabinoids and action on the NMDA receptors. The effect on pain has been shown to be related to the cortically evoked potentials.23
The antipyretic effect is reported to be linked to the effect on the prostanoid synthesis due to the fact that the prostanoids are the main signaling mediator of pyresis in the hypothalamic-preoptic region.23
The use of ibuprofen in dental procedures is attributed to the local inhibition of prostanoid production as well as to anti-oedemic activity and an increase of plasma beta-endorphins. Some reports have suggested a rapid local reduction of the expression of COX-2 in dental pulp derived by the administration of ibuprofen.23
The administration of ibuprofen in patients with rheumatic diseases has shown to control joint symptoms.10
Ibuprofen is largely used in OTC products such as an agent for the management of dysmenorrhea which has been proven to reduce the amount of menstrual prostanoids and to produce a reduction in the uterine hypercontractility.17 As well, it has been reported to reduce significantly the fever and the pain caused by migraines.18,19 This effect is thought to be related to the effect on platelet activation and thromboxane A2 production which produces local vascular effects in the affected regions. This effect is viable as ibuprofen can enter in the central nervous system.23
In the investigational uses of ibuprofen, it has been reported to reduce neurodegeneration when given in low doses over a long time.20 On the other hand, its use in Parkinson disease is related to the importance of inflammation and oxidative stress in the pathology of this condition.21 The use of ibuprofen for breast cancer is related to a study that shows a decrease of 50% in the rate of breast cancer.22
The exact mechanism of action of ibuprofen is unknown. However, ibuprofen is considered an NSAID and thus it is a non-selective inhibitor of cyclooxygenase, which is an enzyme involved in prostaglandin (mediators of pain and fever) and thromboxane (stimulators of blood clotting) synthesis via the arachidonic acid pathway.27
Ibuprofen is a non-selective COX inhibitor and hence, it inhibits the activity of both COX-1 and COX-2. The inhibition of COX-2 activity decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever, and swelling while the inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration.25
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It is very well absorbed orally and the peak serum concentration can be attained in 1 to 2 hours after extravascular administration. When ibuprofen is administered immediately after a meal there is a slight reduction in the absorption rate but there is no change in the extent of the absorption.10
When orally administered, the absorption of ibuprofen in adults is very rapidly done in the upper GI tract.23 The average Cmax, Tmax and AUC ranges around 20 mcg/ml, 2 h and 70 mcg.h/ml. These parameters can vary depending on the enantiomer form, route, and dose of administration.23
The apparent volume of distribution of ibuprofen is of 0.1 L/kg.25
Ibuprofen dosage is more than 99% bound to plasma proteins and site II of purified albumin, binding appears to be saturable and becomes non-linear at concentrations exceeding 20 mcg/ml.10
Ibuprofen is rapidly metabolized and biotransformed in the liver to the formation of major metabolites which are the hydroxylated and carboxylated derivatives.10 As soon as it is absorbed, the R-enantiomer undergoes extensive enantiomeric conversion (53-65%) to the more active S-enantiomer in vivo by the activity of alpha-methylacyl-CoA racemase.24
Ibuprofen metabolism can be divided in phase I which is represented by the hydroxylation of the isobutyl chains for the formation of 2 or 3-hydroxy derivatives followed by oxidation to 2-carboxy-ibuprofen and p-carboxy-2-propionate. These oxidative reactions are performed by the activity of the cytochrome P450 isoforms CYP 2C9, CYP 2C19 and CYP 2C8. Therefore, these enzymes participate in the oxidation of the alkyl side chain to hydroxyl and carboxyl derivatives. From this enzymes, the major catalyst in the formation of oxidative metabolites is the isoform CYP 2C9.23
The metabolic phase I is followed by a phase II in which the oxidative metabolites may be conjugated to glucuronide prior to excretion. This activity forms phenolic and acyl glucuronides.23
Ibuprofen is rapidly metabolized and eliminated in the urine thus, this via accounts for more than 90% of the administered dose. It is completely eliminated in 24 hours after the last dose and almost all the administered dose goes through metabolism, representing about 99% of the eliminated dose.10 The biliary excretion of unchanged drug and active phase II metabolites represents 1% of the administered dose.23
In summary, ibuprofen is excreted as metabolites or their conjugates. The elimination of ibuprofen is not impaired by old age or the presence of renal impairment.10 قرص ibuprofen 200
The serum half-life of ibuprofen is 1.2-2 hours.10 In patients with a compromised liver function, the half-life can be prolonged to 3.1-3.4 hours.23
The clearance rate ranges between 3-13 L/h depending on the route of administration, enantiomer type and dosage.23
The symptoms of overdose are presented in individuals that consumed more than 99 mg/kg. Most common symptoms of overdose are abdominal pain, nausea, vomiting, lethargy, vertigo, drowsiness (somnolence), dizziness and insomnia. Other symptoms of overdose include headache, loss of consciousness, tinnitus, CNS depression, convulsions and seizures. May rarely cause metabolic acidosis, abnormal hepatic function, hyperkalemia, renal failure, dyspnea, respiratory depression, coma, acute renal failure, and apnea (primarily in very young pediatric patients).26
The reported LD50 of ibuprofen is of 636 mg/kg in rat, 740 mg/kg in mouse and 495 mg/kg in guinea pig.MSDS
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Drug created on June 13, 2005 07:24 / Updated on July 13, 2019 00:37
This medication is a nonsteroidal anti-inflammatory drug (NSAID). Typically, it is used for pain or to reduce fever. It may also be used for the relief of osteoarthritis, for menstrual pain, as well as for other uses. Its effects can be felt within 1 hour.
This medication is typically used 4 times a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Generally, it is used only as needed.
Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. It is not advisable to chew or crush this medication since it has an unpleasant taste.
This medication may irritate the stomach, and should be taken with food. It is best to avoid coffee, spicy food or alcohol.
In addition to its desired action, this medication may cause some side effects, notably:
قرص ibuprofen 200
Each person may react differently to a treatment. If you think this medication may be causing side effects (including those described here, or others), talk to your doctor or pharmacist. He or she can help you to determine whether or not the medication is the source of the problem.
As with most medications, this product should be stored at room temperature. Store it in a secure location where it will not be exposed to excessive heat, moisture or direct sunlight. Keep it out of reach of young children. Make sure that any leftover portion is disposed of safely.
It is not recommended to combine this drug with another antiinflammatory. Carefully check for the presence of ibuprofen (Advil, Motrin), naproxen (Aleve) or diclofenac (Voltaren Emulgel) on drug labels.
This medication may interact with other medications or supplements, sometimes significantly. Many interactions, however, may be dealt with by a dosage adjustment or a change in medication schedule. Check with your pharmacist before using this medication in combination with any other medications (including non-prescription products), vitamins or natural products.
It is important to tell the health professionals you consult:
